Zobrazeno 1 - 10
of 389
pro vyhledávání: '"Erminio Costa"'
Autor:
Erminio Costa, John Davis, Dennis R. Grayson, Alessandro Guidotti, George D. Pappas, Christine Pesold
Publikováno v:
Neurobiology of Disease, Vol 8, Iss 5, Pp 723-742 (2001)
In this review, we will first present a brief overview of the current understanding of: (a) the biology of reelin; (b) the putative reelin signaling pathways via integrin receptor stimulation; (c) the cytosolic adapter protein DAB1, which appears to
Externí odkaz:
https://doaj.org/article/e174bd8ea8014b8faf7c7d0d37a0dd6a
Publikováno v:
Toxicological Sciences. 120:136-145
Diazepam (DZ), the preferred anticonvulsant benzodiazepine (BZ) for the treatment of organophosphate (OP) nerve agent-induced seizures and neuronal damage, has been associated with unwanted effects such as sedation, amnesia, cardiorespiratory depress
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d04c0269e110b23180411c45e9c73a57
https://doi.org/10.1093/toxsci/kfq356
https://doi.org/10.1093/toxsci/kfq356
Autor:
Patricia Tueting, Bashkim Kadriu, Fabio Pibiri, John M. Davis, Erminio Costa, Alessandro Guidotti, Marin Veldic
Publikováno v:
NeuroReport. 21:543-548
Schizophrenia postmortem brain is characterized by gamma aminobutyric acid downregulation and by decreased dendritic spine density in frontal cortex. Protracted L-methionine treatment exacerbates schizophrenia symptoms, and our earlier work (Tremoliz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::604b1c30ef1571db75987dd96d6cfcb9
https://doi.org/10.1097/wnr.0b013e3283373126
https://doi.org/10.1097/wnr.0b013e3283373126
Publikováno v:
Epigenomics. 1:201-211
Recent advances in schizophrenia and bipolar disorder research suggest that a dysfunction of GABAergic neurotransmission that is operative in telencephalic structures may be an important dynamic mechanism associated with psychosis. We propose that th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1215ae3d3bd35c9573e9dbf2c56ae6c
https://doi.org/10.2217/epi.09.2
https://doi.org/10.2217/epi.09.2
Autor:
Ekrem Maloku, Dennis R. Grayson, W. B. Ruzicka, Ying Chen, Rosalba Satta, Alessandro Guidotti, Erbo Dong, Marin Veldic, Erminio Costa, Marija Kundakovic, Adrian Zhubi
Publikováno v:
Expert Review of Neurotherapeutics. 9:87-98
The neuronal GABAergic mechanisms that mediate the symptomatic beneficial effects elicited by a combination of antipsychotics with valproate (a histone deacetylase inhibitor) in the treatment of psychosis (expressed by schizophrenia or bipolar disord
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a395c00f748cf3053000da677032d72d
https://doi.org/10.1586/14737175.9.1.87
https://doi.org/10.1586/14737175.9.1.87
Autor:
Rosalba Satta, Ekrem Maloku, Adrian Zhubi, Erminio Costa, Alessandro Guidotti, Mihály Hajós, Fabio Pibiri
Publikováno v:
Proceedings of the National Academy of Sciences. 105:16356-16361
Tobacco smoking is frequently abused by schizophrenia patients (SZP). The major synaptically active component inhaled from cigarettes is nicotine, hence the smoking habit of SZP may represent an attempt to use nicotine self-medication to correct ( i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32f9b76069556bc3a12e0cbc05ba4412
https://doi.org/10.1073/pnas.0808699105
https://doi.org/10.1073/pnas.0808699105
Autor:
Bashkim Kadriu, Erminio Costa, Graziano Pinna, James Auta, Alessandro Guidotti, Fabio Pibiri, Alan P. Kozikowski
Publikováno v:
Proceedings of the National Academy of Sciences. 105:14169-14174
Diisopropyl fluorophosphate (DFP) causes neurotoxicity related to an irreversible inhibition of acetylcholinesterase (AChE). Management of this intoxication includes: ( i ) pretreatment with reversible blockers of AChE, ( ii ) blockade of muscarinic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76c323147fbb577f336262d9fa57f11d
https://doi.org/10.1073/pnas.0807172105
https://doi.org/10.1073/pnas.0807172105
Publikováno v:
Proceedings of the National Academy of Sciences. 105:13614-13619
Cortical GABAergic dysfunction, a hallmark of both schizophrenia (SZ) and bipolar (BP) disorder pathophysiologies may relate to the hypermethylation of GABAergic gene promoters (i.e., reelin and GAD67). Benefits elicited by a combination of atypical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dbe6afa37bcc3e2941a49af90a29bf9
https://doi.org/10.1073/pnas.0805493105
https://doi.org/10.1073/pnas.0805493105
Autor:
Roberto Carlos Agis-Balboa, Erminio Costa, Fabio Pibiri, Marianela Nelson, Alessandro Guidotti, Graziano Pinna
Publikováno v:
Neurochemical Research. 33:1990-2007
The neurosteroid allopregnanolone is a potent positive allosteric modulator of GABA action at GABA(A) receptors. Allopregnanolone is synthesized in the brain from progesterone by the sequential action of 5alpha-reductase type I (5alpha-RI) and 3alpha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc922c35bd559bc3455ec3b8ef8f3022
https://doi.org/10.1007/s11064-008-9718-5
https://doi.org/10.1007/s11064-008-9718-5
Publikováno v:
Proceedings of the National Academy of Sciences. 105:5567-5572
Mice subjected to social isolation (3–4 weeks) exhibit enhanced contextual fear responses and impaired fear extinction. These responses are time-related to a decrease of 5α-reductase type I (5α-RI) mRNA expression and allopregnanolone (Allo) leve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbe8fe2a90d675fbe19ff1525ce8e7ed
https://doi.org/10.1073/pnas.0801853105
https://doi.org/10.1073/pnas.0801853105