Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Ermes Vanotti"'
Autor:
Daniele Donati, Andrea Lombardi Borgia, Ettore Perrone, Lucio Ceriani, Chiara Marchionni, Paolo Orsini, Marcella Nesi, Luisa Rusconi, Paola Magnaghi, Marina Fasolini, Nilla Avanzi, G. Canevari, Arturo Galvani, Maristella Colombo, Patrizia Banfi, Elena Ardini, Laura Buffa, Antonella Isacchi, Christian Orrenius, Roberto Bossi, Maria Beatrice Saccardo, Ermes Vanotti, Claudio Fiorelli, Francesco Fiorentini, Maria Menichincheri, Achille Panzeri, Luca Corti, Enrico Pesenti, Eduard R. Felder
Publikováno v:
Journal of Medicinal Chemistry. 59:3392-3408
Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase responsible for the development of different tumor types. Despite the remarkable clinical activity of crizotinib (Xalkori), the first ALK inhibitor approved in 2011, the emergence of resi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdc806429f7d1f3155f365de5d16bf20
https://doi.org/10.1021/acs.jmedchem.6b00064
https://doi.org/10.1021/acs.jmedchem.6b00064
Autor:
Ermes Vanotti, Paola Vianello, Marcella Nesi, Marina Caldarelli, Marco Tato, Teresa Disingrini, Maria Menichincheri
Publikováno v:
Tetrahedron. 65:10418-10423
The regioselective synthesis of halogenated aminopyrimidinyl-pyrroles as useful scaffolds for the preparation of diversified selective kinase inhibitors is described. The chemistry is simple and mostly based on the use of N-halosuccinimides under mil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::46ba3723cc91b09794d10e1716a3fbbe
https://doi.org/10.1016/j.tet.2009.10.030
https://doi.org/10.1016/j.tet.2009.10.030
Autor:
Sandra Healy, Jürgen Moll, Nilla Avanzi, Clara Albanese, Antonella Ciavolella, Marina Cattoni, Francesco Sola, Pierluigi Tenca, Marcello Tibolla, Veronica Patton, Dario Ballinari, Sonia Rainoldi, Alessia Montagnoli, Enrico Pesenti, Rachele Alzani, Aaron Bensimon, Antonella Isacchi, Maria Menichincheri, Ermes Vanotti, Vanessa Marchesi, Deborah Brotherton, Francesco Fiorentini, Daniele Volpi, Barbara Valsasina, Corrado Santocanale, Antonio Molinari, Valter Croci
Publikováno v:
Nature Chemical Biology. 4:357-365
Cdc7 is an essential kinase that promotes DNA replication by activating origins of replication. Here, we characterized the potent Cdc7 inhibitor PHA-767491 (1) in biochemical and cell-based assays, and we tested its antitumor activity in rodents. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82b0682f37a242c0995b980c8fd0bee4
https://doi.org/10.1038/nchembio.90
https://doi.org/10.1038/nchembio.90
Autor:
Ermes Vanotti, Antonella Ermoli, Marcello Tibolla, Maria Menichincheri, Vittorio Pinciroli, Roberto Biancardi, Alberto Bargiotti
Publikováno v:
Tetrahedron. 58:3361-3370
Treatment of guanosine with arylmethyl halides in N,N-dimethylacetamide results in a series of 3,7-bis(arylmethyl) guanines and 7,9-bis(arylmethyl)guaninium halides. The same reaction on 7-arylmethyl guanines yields 3,7- and 7,9- differently disubsti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df2c63b35de744e4363183ecc24df11f
https://doi.org/10.1016/s0040-4020(02)00297-1
https://doi.org/10.1016/s0040-4020(02)00297-1
Autor:
Francesco Colotta, Roberto D'Alessio, Annamaria Isetta, Rossi Arsenia, Alberto Bargiotti, Marcello Tibolla, Pietro Motta, Ermes Vanotti, Orlando Carlini, Mario Rossi, Mario Ferrari, Paola Gnocchi, Nicola Mongelli
Publikováno v:
Journal of Medicinal Chemistry. 43:2557-2565
Prodigiosins (Ps) represent a family of naturally occurring red pigments characterized by a common pyrrolylpyrromethene skeleton. Some members of this family have been shown to possess interesting immunosuppressive properties exerted with a novel mec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92ff40ea4fec83948e36be4b266423b6
https://doi.org/10.1021/jm001003p
https://doi.org/10.1021/jm001003p
Publikováno v:
Tetrahedron Letters. 50:3098-3100
A rapid and efficient procedure for the preparation of 5-benzyl-3-aminoindazoles 1 is reported. Key intermediates are fluoro-cyano diarylmethanes 2 which have been obtained by two different synthetic approaches. Benefits of these methods result from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c6de6cb11a66cc0a12a6a83b23020bfa
https://doi.org/10.1016/j.tetlet.2009.04.024
https://doi.org/10.1016/j.tetlet.2009.04.024
Autor:
Anna Vulpetti, Ermes Vanotti, Nicola Mongelli, Monica Donghi, Cesare Gennari, Michela Carcano
Publikováno v:
The Journal of Organic Chemistry. 62:4746-4755
A very simple, new, and straightforward approach to the Paclitaxel (Taxol) and Docetaxel (Taxotere) side chains has been developed using the imine addition reaction of thioester-derived boron enola...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee59c04006223af6b08696424f38872c
https://doi.org/10.1021/jo9703212
https://doi.org/10.1021/jo9703212
Autor:
Maristella Colombo, E. Arlandini, Maria Menichincheri, Vittorio Pinciroli, Walter Ceccarelli, Nicola Mongelli, Ermes Vanotti, Domenico Fusar-Bassini, L Franzoi
Publikováno v:
Tetrahedron Letters. 38:3301-3304
Upon treatment of 7-triethylsilyl-10, 13-dideoxy-13-imino baccatin III ( 2 ) subsequently with diazomethane and m-chloroperbenzoic acid a few novel derivatives, namely methylimine 3 and oximes 4 and 5 , were obtained. Interestingly, 4 is characterize
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::13876959ebf810408e32e647d40c38fe
https://doi.org/10.1016/s0040-4039(97)00591-1
https://doi.org/10.1016/s0040-4039(97)00591-1
Autor:
Walter Ceccarelli, Maria Menichincheri, Vittorio Pinciroli, Domeico Fusar-Bassini, Nicola Mongelli, Ermes Vanotti
Publikováno v:
Tetrahedron Letters. 37:9365-9368
Treatment of 7-triethylsilyl-13-oxobaccatin III (1) with sodium hydride and methyl iodide gave the methylated ten-membered ring compound 2 that rearranged, via intramolecular aldol condensation, to unsaturated decalin ring system (3, 4, 5). These mol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab7b9c820f32de06a2174ee7ec809153
https://doi.org/10.1016/s0040-4039(97)82965-6
https://doi.org/10.1016/s0040-4039(97)82965-6
Publikováno v:
Angewandte Chemie. 108:1809-1812
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::70dc648573f459b8c6edc756ec40ef4b
https://doi.org/10.1002/ange.19961081522
https://doi.org/10.1002/ange.19961081522