Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Ermenegilda, McCauley"'
Autor:
Malcolm MacCoss, John A. Schmidt, Linda A. Egger, Linus S. Lin, Jin Cao, Richard A. Mumford, Gail Van Riper, William K. Hagmann, Thomas J. Lanza, Usha Kidambi, Ermenegilda McCauley
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:133-136
N-(3,5-Dichlorophenylsulfonyl)-(R)-thioprolyl biarylalanine 10a has been identified as a potent and specific antagonist of the α4β1 integrin. Altering the configuration of thioproline from R to S led to a series of dual antagonists of α4β1 and α
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be21700ed8b07ef0f15432675f0d335e
https://doi.org/10.1016/s0960-894x(01)00705-3
https://doi.org/10.1016/s0960-894x(01)00705-3
Autor:
David A. Geller, Ermenegilda McCauley, Michael J. Tocci, Timothy R. Billiar, Malcolm MacCoss, Andreas K. Nussler, Stephan K. Grant, Kenny K. Wong, Jimmy R. Calaycay, Theresa M. Kelly, Jeffrey R. Weidner, Patrick R. Griffin, S.M. Raju, Tracey Klatt, Shrenik K. Shah, Hongbo Qi, Richard A. Mumford, Gloria C. Wolfe, Hollis R. Williams, John A. Schmidt, Nancy I. Hutchinson, Karen L. MacNaul
Publikováno v:
Journal of Biological Chemistry. 271:28212-28219
Recombinant human inducible nitric-oxide synthase (rH-iNOS) was expressed in the baculovirus system and purified by a novel immunoaffinity column. rH-iNOS and its native counterpart from cytokine-stimulated primary hepatocytes exhibited similar molec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4027a4d1d0842141651cc546b8598808
https://doi.org/10.1074/jbc.271.45.28212
https://doi.org/10.1074/jbc.271.45.28212
Autor:
Linus S. Lin, Thomas J. Lanza, John A. Schmidt, Richard A. Mumford, Xinchun Tong, Laurie A. Castonguay, Theodore M. Kamenecka, Linda A. Egger, Gail Van Riper, Malcolm MacCoss, William K. Hagmann, Ermenegilda McCauley
Publikováno v:
Bioorganicmedicinal chemistry letters. 14(9)
We have designed and synthesized a series of heterocyclic bioisosteres for an anilide based on molecular modeling. Excellent potency was retained in the benzoxazole and the benzimidazole derivatives, where a hydrogen bond acceptor is appropriately po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95aa16018dc9f938b0652dcf7409b7ce
https://pubmed.ncbi.nlm.nih.gov/15081035
https://pubmed.ncbi.nlm.nih.gov/15081035
Autor:
Linda A. Egger, Ermenegilda McCauley, George A. Doherty, Richard A. Mumford, Sharon Tong, Malcolm MacCoss, William K. Hagmann, Ginger X. Yang, Edite Borges, Linda L. Chang, Usha Kidambi, Gail Van Riper, John A. Schmidt
Publikováno v:
Bioorganicmedicinal chemistry letters. 12(11)
A series of substituted tetrahydrofuroyl-1-phenylalanine derivatives was prepared and evaluated as VLA-4 antagonists. Substitution of the alpha carbon of the tetrahydrofuran with aryl groups increased the specificity for VLA-4 versus alpha(4)beta(7)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed1ec17a5d90ff0d60d17f0b4fc34072
https://pubmed.ncbi.nlm.nih.gov/12031329
https://pubmed.ncbi.nlm.nih.gov/12031329
Autor:
George A. Doherty, Richard A. Mumford, Theodore M. Kamenecka, William K. Hagmann, Sharon Tong, Ermenegilda McCauley, Gail Van Riper
Publikováno v:
Bioorganicmedicinal chemistry letters. 12(5)
A series of N-arylated phenylalanine derivatives has been synthesized and has been shown to be potent inhibitors of the integrin VLA-4. N-phenyl and N-heteroaryl derivatives with hydrogen bond acceptors in the meta position demonstrated low nanomolar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b6a11b82a0c8cca7a5814aff338b1d5
https://pubmed.ncbi.nlm.nih.gov/11858990
https://pubmed.ncbi.nlm.nih.gov/11858990
Autor:
Thomas J. Lanza, Ralph A. Stearns, Theodore M. Kamenecka, Adria Colletti, John A. Schmidt, Linda A. Egger, Plato A. Magriotis, Gail Van Riper, Kathryn A. Lyons, Malcolm MacCoss, Richard A. Mumford, Xinchun Tong, Stella H. Vincent, Ermenegilda McCauley, Stephen E. de Laszlo, Ihor E. Kopka, Judy Fenyk-Melody, Yohannes Teffera, William K. Hagmann, David N. Young, Philippe L. Durette, Linus S. Lin, Usha Kidambi
Publikováno v:
Bioorganicmedicinal chemistry letters. 12(4)
Acylated beta-amino acids are described as potent, specific and orally bioavailable antagonists of VLA-4. The initial lead was identified from a combinatorial library. Subsequent optimization using a traditional medicinal chemistry approach led to si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e672c8a86c80a062a6be67aff800453
https://pubmed.ncbi.nlm.nih.gov/11844683
https://pubmed.ncbi.nlm.nih.gov/11844683
Autor:
Linus S, Lin, Thomas, Lanza, Ermenegilda, McCauley, Gail, Van Riper, Usha, Kidambi, Jin, Cao, Linda A, Egger, Richard A, Mumford, John A, Schmidt, Malcolm, MacCoss, William K, Hagmann
Publikováno v:
Bioorganicmedicinal chemistry letters. 12(2)
N-(3,5-Dichlorophenylsulfonyl)-(R)-thioprolyl biarylalanine 10a has been identified as a potent and specific antagonist of the alpha(4)beta(1) integrin. Altering the configuration of thioproline from R to S led to a series of dual antagonists of alph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1b6792c29bd570b8392c998169bd4d28
https://pubmed.ncbi.nlm.nih.gov/11755338
https://pubmed.ncbi.nlm.nih.gov/11755338
Autor:
John W. Kozarich, Renee M. Chabin, Ermenegilda McCauley, John A. Schmidt, Sayyaparaju Madhusudanaraju, Nancy I. Hutchinson, Karen L. MacNaul, Gloria C. Wolfe, Kenny K. Wong, Jimmy R. Calaycay, Theresa M. Kelly
Publikováno v:
Biochemistry. 35(29)
Nitric oxide synthase catalyzes the pyridine nucleotide-dependent oxidation of L-arginine to nitric oxide and L-citrulline. It is a specialized cytochrome P450 monooxygenase that is sensitive to inhibition by imidazole. Steady-state kinetic studies o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4ab8d8237039f4f531c6f7296e150df
https://pubmed.ncbi.nlm.nih.gov/8755738
https://pubmed.ncbi.nlm.nih.gov/8755738
Autor:
Jon D. Polishook, Russell B. Lingham, Claude Dufresne, Lin Kong, Gregory E. Koch, Isabel Martin, John G. Ondeyka, Jerrold M. Liesch, Tannis M. Jurgens, Ermenegilda McCauley, Hans T. Beck, Robert P. Borris, Carmen Cascales, Steven R. King, Otto D. Hensens, Susan L. Raghoobar, Fernando Pelaez, Michael J. Salvatore, Suzanne E. Gartner, Deborah L. Zink, Maria Teresa Diez, Michael J. Balick, Amy Hsu
Publikováno v:
Journal of natural products. 57(6)
gamma-Pyrone-3-acetic acid (L-741,494) is a novel metabolite produced by a culture of the fungal genus Xylaria. This substance is a water-soluble, competitive, irreversible inhibitor of Interleukin-1 beta Converting Enzyme that is inactive against pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45e9a2ee1fd30271b159348c420e883a
https://pubmed.ncbi.nlm.nih.gov/7931364
https://pubmed.ncbi.nlm.nih.gov/7931364
Autor:
Thomas J. Lanza, Plato A. Magriotis, Ralph A. Stearns, Malcolm MacCoss, Kathryn A. Lyons, Stella H. Vincent, Usha Kidambi, Adria Colletti, Linus S. Lin, Richard A. Mumford, Xinchun Tong, David N. Young, Stephen E. de Laszlo, Judy Fenyk-Melody, Ihor E. Kopka, John A. Schmidt, Philippe L. Durette, William K. Hagmann, Gail Van Riper, Ermenegilda McCauley, Yohannes Teffera, Theodore M. Kamenecka, Linda A. Egger
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:1695
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b6533e061d05741fe26289ca8546284
https://doi.org/10.1016/s0960-894x(02)00231-7
https://doi.org/10.1016/s0960-894x(02)00231-7