Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Ermelindo C Leal"'
Autor:
Áurea F Castilho, Célia A Aveleira, Ermelindo C Leal, Núria F Simões, Carolina R Fernandes, Rita I Meirinhos, Filipa I Baptista, António F Ambrósio
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e42428 (2012)
Diabetic retinopathy is a leading cause of visual loss and blindness, characterized by microvascular dysfunction. Hyperglycemia is considered the major pathogenic factor for the development of diabetic retinopathy and is associated with increased oxi
Externí odkaz:
https://doaj.org/article/a4ee5ee8c61841438004079329e44f92
Autor:
Renato M. S. Cardoso, Silvia C. Rodrigues, Claudia F. Gomes, Filipe V. Duarte, Maryse Romao, Ermelindo C. Leal, Patricia C. Freire, Ricardo Neves, Joana Simões‐Correia
Publikováno v:
Stem Cells Translational Medicine, Vol 10, Iss 6, Pp 910-921 (2021)
Abstract Extracellular vesicles (EV) are a promising therapeutic tool in regenerative medicine. These particles were shown to accelerate wound healing, through delivery of regenerative mediators, such as microRNAs. Herein we describe an optimized and
Externí odkaz:
https://doaj.org/article/e1f2c32bd9914a6886fa4ef15b781b83
Autor:
Michelle V. Mouritzen, Marija Petkovic, Katrine Qvist, Steen S. Poulsen, Susana Alarico, Ermelindo C. Leal, Louise T. Dalgaard, Nuno Empadinhas, Eugenia Carvalho, Håvard Jenssen
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 20, Iss , Pp 726-739 (2021)
Bovine lactoferricin (LFcinB) has antimicrobial and immunomodulatory properties; however, the effects on diabetic wound healing remain poorly understood. The wound healing potential of LFcinB was investigated with in vitro, ex vivo, and in vivo model
Externí odkaz:
https://doaj.org/article/ec54cc756c054ca4b2611f428ce5d18c
Publikováno v:
Antibiotics, Vol 12, Iss 3, p 467 (2023)
Diabetic foot ulcers (DFU) are one of the most serious and devastating complications of diabetes and account for a significant decrease in quality of life and costly healthcare expenses worldwide. This condition affects around 15% of diabetic patient
Externí odkaz:
https://doaj.org/article/fb35dad3ff71492189d4db8e17661051
Publikováno v:
Biomolecules, Vol 11, Iss 12, p 1894 (2021)
Diabetic foot ulcer (DFU) is a devastating complication, affecting around 15% of diabetic patients and representing a leading cause of non-traumatic amputations. Notably, the risk of mixed bacterial–fungal infection is elevated and highly associate
Externí odkaz:
https://doaj.org/article/cf90983f0f014168893bc0ecca104587
Autor:
Ermelindo C Leal, Tatiana Emanuelli, Diana Santos, João Moura, Ana Catarina RG Fonseca, Ana Burgeiro, Eugenia Carvalho
Publikováno v:
Journal of Molecular Endocrinology. 70
Dysfunction in key cellular organelles has been linked to diabetic complications. This study intended to investigate the alterations in the unfolded protein response (UPR), autophagy, and mitochondrial function, which are part of the endoplasmic reti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d7ffcd28f02c5832c61e3909bf06ac05
https://doi.org/10.1530/jme-22-0122
https://doi.org/10.1530/jme-22-0122
Autor:
Håvard Jenssen, Eugenia Carvalho, Susana Alarico, Marija Petkovic, Steen Seier Poulsen, Katrine Qvist, Michelle Vang Mouritzen, Ermelindo C. Leal, Louise Torp Dalgaard, Nuno Empadinhas
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 20, Iss, Pp 726-739 (2021)
Molecular Therapy. Methods & Clinical Development
Mouritzen, M V, Petkovic, M, Qvist, K, Poulsen, S S, Alarico, S, Leal, E C, Dalgaard, L T, Empadinhas, N, Carvalho, E & Jenssen, H 2021, ' Improved diabetic wound healing by LFcinB is associated with relevant changes in the skin immune response and microbiota ', Molecular Therapy-Methods and Clinical Development, vol. 20, pp. 726-739 . https://doi.org/10.1016/j.omtm.2021.02.008
Molecular Therapy. Methods & Clinical Development
Mouritzen, M V, Petkovic, M, Qvist, K, Poulsen, S S, Alarico, S, Leal, E C, Dalgaard, L T, Empadinhas, N, Carvalho, E & Jenssen, H 2021, ' Improved diabetic wound healing by LFcinB is associated with relevant changes in the skin immune response and microbiota ', Molecular Therapy-Methods and Clinical Development, vol. 20, pp. 726-739 . https://doi.org/10.1016/j.omtm.2021.02.008
Bovine lactoferricin (LFcinB) has antimicrobial and immunomodulatory properties; however, the effects on diabetic wound healing remain poorly understood. The wound healing potential of LFcinB was investigated with in vitro, ex vivo, and in vivo model
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afc619b9d706190468c2266b0e6ef8c9
https://doi.org/10.1016/j.omtm.2021.02.008
https://doi.org/10.1016/j.omtm.2021.02.008
Autor:
Hugo Fernandes, Alessandra Zonnari, Ricardo Abreu, Sezin Aday, Marta Barão, Inês Albino, Miguel Lino, Ana Branco, Cátia Seabra, Tânia Barata, Ermelindo C. Leal, José Guilherme Tralhão, Lino Gonçalves, Alwin de Jong, Hendrika A.B. Peters, Margreet R. de Vries, Paula da Costa Martins, Paul H.A. Quax, Lino Ferreira
Publikováno v:
Molecular Therapy-Nucleic Acids
Molecular Therapy-Nucleic Acids, 28, 307-327. Cell Press
Molecular Therapy-Nucleic Acids, 28, 307-327. CELL PRESS
Molecular Therapy-Nucleic Acids, 28, 307-327. Cell Press
Molecular Therapy-Nucleic Acids, 28, 307-327. CELL PRESS
Endothelial cell (EC) activity is essential for tissue regeneration in several (patho)physiological contexts. However, our capacity to deliver in vivo biomolecules capable of controlling EC fate is relatively limited. Here, we screened a library of m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::889c3ba71c27f69b70e76a273dd63efd
https://hdl.handle.net/10316/99911
https://hdl.handle.net/10316/99911
Autor:
Helena Henriques-Antunes, Ivana Kostic, Lino Ferreira, Célia Gomes, Renato M. S. Cardoso, Miguel M. Lino, Adrian Jiménez-Balsa, Joana Correia, Eugenia Carvalho, Jeffrey M. Karp, Ana M.C. Barradas, Alessandra Zonari, Ermelindo C. Leal
Publikováno v:
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
ACS Nano
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
ACS Nano
Small extracellular vesicles (SEVs) offer a promising strategy for tissue regeneration, yet their short lifetime at the injured tissue limits their efficacy. Here, we show that kinetics of SEV delivery impacts tissue regeneration at tissue, cellular,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ef8a9070cbc0d11851ac387405b19a6
https://doi.org/10.1021/acsnano.9b00376
https://doi.org/10.1021/acsnano.9b00376
Autor:
Dorinda Marques-da-Silva, Catherine Ledent, Ermelindo C. Leal, Roksana M. Pirzgalska, Eugenia Carvalho, Liane I.F. Moura, Attila Köfalvi
Publikováno v:
Experimental gerontology. 154
Background The cannabinoid receptor type-1 (CB1R) is a major regulator of metabolism, growth and inflammation. Yet, its potential role in the skin is not well understood. Our aim was to evaluate the role of CB1R in aging-like diabetic skin changes by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d8d991682b174ec4ea40ef6fe2bd027
https://pubmed.ncbi.nlm.nih.gov/34437952
https://pubmed.ncbi.nlm.nih.gov/34437952