Zobrazeno 1 - 10 of 51 pro vyhledávání: '"Ermanna Rovida"'
1
Akademický článek
Stem Cell Modeling of Neuroferritinopathy Reveals Iron as a Determinant of Senescence and Ferroptosis during Neuronal Aging
Autor: Anna Cozzi, Daniel I. Orellana, Paolo Santambrogio, Alicia Rubio, Cinzia Cancellieri, Serena Giannelli, Maddalena Ripamonti, Stefano Taverna, Giulia Di Lullo, Ermanna Rovida, Maurizio Ferrari, Gian Luca Forni, Chiara Fiorillo, Vania Broccoli, Sonia Levi
Publikováno v: Stem Cell Reports, Vol 13, Iss 5, Pp 832-846 (2019)
Summary: Neuroferritinopathy (NF) is a movement disorder caused by alterations in the L-ferritin gene that generate cytosolic free iron. NF is a unique pathophysiological model for determining the direct consequences of cell iron dysregulation. We es
Externí odkaz: https://doaj.org/article/1a80b9ac5a774715806543d0e61b3993
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2
Akademický článek
Neuroferritinopathy: From ferritin structure modification to pathogenetic mechanism
Autor: Sonia Levi, Ermanna Rovida
Publikováno v: Neurobiology of Disease, Vol 81, Iss , Pp 134-143 (2015)
Neuroferritinopathy is a rare, late-onset, dominantly inherited movement disorder caused by mutations in L-ferritin gene. It is characterized by iron and ferritin aggregate accumulation in brain, normal or low serum ferritin levels and high variable
Externí odkaz: https://doaj.org/article/57e9ad6d8bbc4a24803a2640d31b1f11
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3
Pathogenic mechanism and modeling of neuroferritinopathy
Autor: Anna Cozzi, Paolo Santambrogio, Maddalena Ripamonti, Sonia Levi, Ermanna Rovida
Publikováno v: Cellular and Molecular Life Sciences. 78:3355-3367
Neuroferritinopathy is a rare autosomal dominant inherited movement disorder caused by alteration of the L-ferritin gene that results in the production of a ferritin molecule that is unable to properly manage iron, leading to the presence of free red
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af6323b985d9c462306e0f6246fd6286
https://doi.org/10.1007/s00018-020-03747-w
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4
Stem Cell Modeling of Neuroferritinopathy Reveals Iron as a Determinant of Senescence and Ferroptosis during Neuronal Aging
Autor: Alicia Rubio, Serena Giannelli, Vania Broccoli, Maurizio Ferrari, Chiara Fiorillo, Daniel Orellana, Ermanna Rovida, Giulia Di Lullo, Paolo Santambrogio, Anna Cozzi, Cinzia Cancellieri, Stefano Taverna, Gian Luca Forni, Maddalena Ripamonti, Sonia Levi
Publikováno v: Stem Cell Reports, Vol 13, Iss 5, Pp 832-846 (2019)
Stem Cell Reports
Summary Neuroferritinopathy (NF) is a movement disorder caused by alterations in the L-ferritin gene that generate cytosolic free iron. NF is a unique pathophysiological model for determining the direct consequences of cell iron dysregulation. We est
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01de26e5458b584eaa7c3e6d4ebdda03
http://www.sciencedirect.com/science/article/pii/S2213671119303315
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5
BRCA1 point mutations in premenopausal breast cancer patients from Central Sudan
Autor: Nasr Eldin Elwali, Gitana Aceto, Ahmed Elhaj, Ida Biunno, Khalid Dafaallah Awadelkarim, Chiara Carmela Spinelli, Annalisa Morgano, Elgaylani Abdalla Eltayeb, Pasquale De Blasio, Ermanna Rovida, Renato Mariani-Costantini, Dafalla Omer Abuidris
Publikováno v: Familial Cancer. 13:437-444
Premenopausal breast cancer (BC) is one of the most common cancers of women in rural Africa and part of the disease load may be related to hereditary predisposition, including mutations in the BRCA1 gene. However, the BRCA1 mutations associated with
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b6b68707bf47757c4cf278e3927454f
https://doi.org/10.1007/s10689-014-9717-4
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6
Exploring the role of the phospholipid ligand in endothelial protein C receptor: A molecular dynamics study
Autor: Luciano Milanesi, Ivan Merelli, Federica Chiappori, Ermanna Rovida
Publikováno v: Proteins: Structure, Function, and Bioinformatics. 78:2679-2690
Endothelial protein C receptor (EPCR) is a CD1-like transmembrane glycoprotein with important regulatory roles in protein C (PC) pathway, enhancing PC's anticoagulant, anti-inflammatory, and antiapoptotic activities. Similarly to homologous CD1d, EPC
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6394e5e6a78a9b8be2dadb998a67a511
https://doi.org/10.1002/prot.22782
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8
Type II protein C deficiency: identification and molecular modelling of two natural mutants with low anticoagulant and normal amidolytic activity
Autor: José Hermida, Cristina Razzari, Sirous Zeinali, Elena M. Faioni, Pier Mannuccio Mannucci, D. Asti, Ermanna Rovida
Publikováno v: British Journal of Haematology. 108:265-271
Two mutations in exons 3 and 9 of the protein C gene were identified by amplification and sequencing from symptomatic probands referred for venous thromboembolism and thrombophilia screening. The phenotype associated with the mutations is a type II p
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3448dfe36f20390c4f3fd4c3545a0cd0
https://doi.org/10.1046/j.1365-2141.2000.01848.x
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9
Effects of modifications near the 2-, 3- and 4-fold symmetry axes on human ferritin renaturation
Autor: Anna Cozzi, Ermanna Rovida, Paolo Arosio, Alberto Albertini, Sonia Levi, Pauline M. Harrison, Paolo Santambrogio, Peter J. Artymiuk, Patrizia Pinto
Publikováno v: Scopus-Elsevier
Europe PubMed Central
Ferritin is a protein of 24 subunits which assemble into a shell with 432 point symmetry. It can be denatured reversibly in acidic guanidine hydrochloride, with the formation of poorly populated renaturation intermediates. In order to increase the ac
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3045a00c6c1e8cb1e1fb717a7a836cc
https://doi.org/10.1042/bj3220461
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10
Molecular dynamics and docking simulation of a natural variant of Activated Protein C with impaired protease activity: implications for integrin-mediated antiseptic function
Autor: Luciano Milanesi, Ermanna Rovida, Gabriele Trombetti, Alessandro Orro, Pasqualina D'Ursi, Marco Moscatelli, Giulia Morra
Publikováno v: Journal of biomolecular structure and dynamics (Online) 33 (2015): 85–92. doi:10.1080/07391102.2013.851033
info:cnr-pdr/source/autori:Pasqualina D'Ursi a*, Alessandro Orro a, Giulia Morra b, Marco Moscatelli ac, Gabriele Trombetti a, Luciano Milanesi a & Ermanna Rovida d*/titolo:Molecular dynamics and docking simulation of a natural variant of Activated Protein C with impaired protease activity: implications for integrin-mediated antiseptic function./doi:10.1080%2F07391102.2013.851033/rivista:Journal of biomolecular structure and dynamics (Online)/anno:2015/pagina_da:85/pagina_a:92/intervallo_pagine:85–92/volume:33
Activated Protein C (APC) is a multifunctional serine protease, primarily known for its anticoagulant function in the coagulation system. Several studies have already elucidated its role in counteracting apoptosis and inflammation in cells, while sig
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b55a12b6ceb20c50b55bcadbad9b347c
https://pubmed.ncbi.nlm.nih.gov/24251463
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