Zobrazeno 1 - 7 of 7 pro vyhledávání: '"Erle Zang"'
2
Interconversion between S- and N-bound L-methionine adducts of Pt(dien)2+ (dien = diethylenetriamine) via dien ring-opened intermediates
Autor: Erle Zang, Peter J. Sadler, Yu Chen, Zijian Guo, Piedad del Socorro Murdoch
Publikováno v: Journal of the Chemical Society, Dalton Transactions. :1503-1508
The reaction between [Pt(15N-dien)Cl]+ 1 and L-methionine (L-MetH) has been studied using [1H,15N] 2D NMR spectroscopy and HPLC, together with 15N-labelled amine ligands. The complex [Pt(dien)(L-MetH-S)]2+ 2 was dominant at neutral pH and converted p
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a9671501a80ed53acb6ccf7954a30872
https://doi.org/10.1039/a709282b
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3
Synthesis of Hexamine Ligands by Using Trityl as an N-Blocking Group
Autor: Erle Zang, Peter J. Sadler
Publikováno v: Synthetic Communications. 27:3145-3150
The amino-groups of diethylenetriamine were regioselectively protected by trityl groups and then reacted with dihalogenated alkylane to give the terminal N-blocked hexamine derivatives, from which a series of hexamine ligands (5 a-f) were obtained by
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8c6782a9d167f40f5de7ef812e36b62b
https://doi.org/10.1080/00397919708004172
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4
[1H,15N] Nuclear magnetic resonance studies of [Pt(dien)Cl]+ (dien = diethylenetriamine): hydrolysis and reactions with nucleotides ‡
Autor: Peter J. Sadler, Yu Chen, Erle Zang, Zijian Guo
Publikováno v: Journal of the Chemical Society, Dalton Transactions. :4107-4112
The anticancer drug cisplatin is activated via hydrolysis before binding to DNA. Although [Pt(dien)Cl]+1 (where dien is diethylenetriamine) has been extensively used as a model for the first step in the binding of cisplatin to DNA and other biologica
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::31f98cf218c07799a33fe13a722e68b3
https://doi.org/10.1039/a704585i
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5
ChemInform Abstract: Synthesis of Hexamine Ligands by Using Trityl as an N-Blocking Group
Autor: Erle Zang, Peter J. Sadler
Publikováno v: ChemInform. 28
The amino-groups of diethylenetriamine were regioselectively protected by trityl groups and then reacted with dihalogenated alkylane to give the terminal N-blocked hexamine derivatives, from which a series of hexamine ligands (5 a-f) were obtained by
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f3a468a51a2dd063b3ab13893d962155
https://doi.org/10.1002/chin.199747084
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7
Recognition of platinum(ii) amine complexes by nucleotides: role ofphosphate and carbonyl groups in ([15N3]diethylenetriamine)-(guanosine 5′-monophosphate)platinum(ii)
Autor: Zijian Guo, Peter J. Sadler, Erle Zang
Publikováno v: Chemical Communications. :27-28
Two-dimensional [ 1 H, 15 N] NMR studies show that in the model monofunctional DNA adduct [Pt([ 15 N 3 ]dien)(5′-GMP-N 7 )] 2+ [5′-GMP = guanosine 5′-monophosphate, dien = 1,5-diamino-3-azapentane (prepared by a novel synthesis from glycine)],
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::186b01f7fdff2bedfc68221231a57a6a
https://doi.org/10.1039/a606275j
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