Zobrazeno 1 - 10
of 299
pro vyhledávání: '"Erle S Robertson"'
Autor:
Rajnish Kumar Singh, Yonggang Pei, Dipayan Bose, Zachary L Lamplugh, Kunfeng Sun, Yan Yuan, Paul Lieberman, Jianxin You, Erle S Robertson
Publikováno v:
eLife, Vol 10 (2021)
The cellular adaptive response to hypoxia, mediated by high HIF1α levels includes metabolic reprogramming, restricted DNA replication and cell division. In contrast to healthy cells, the genome of cancer cells, and Kaposi’s sarcoma associated herp
Externí odkaz:
https://doaj.org/article/4cb01fb50cda4de298ad1eeae6fd5e1a
Autor:
Chandrima Gain, Samaresh Malik, Shaoni Bhattacharjee, Arijit Ghosh, Erle S Robertson, Benu Brata Das, Abhik Saha
Publikováno v:
PLoS Pathogens, Vol 16, Iss 2, p e1008105 (2020)
Epstein-Barr virus (EBV) nuclear oncoprotein EBNA3C is essential for B-cell transformation and development of several B-cell lymphomas particularly those are generated in an immuno-compromised background. EBNA3C recruits ubiquitin-proteasome machiner
Externí odkaz:
https://doaj.org/article/b33750fd9e56466d835db740a46ffee8
Autor:
Rajnish Kumar Singh, Zachary L Lamplugh, Fengchao Lang, Yan Yuan, Paul Lieberman, Jianxin You, Erle S Robertson
Publikováno v:
PLoS Pathogens, Vol 15, Iss 9, p e1008025 (2019)
Kaposi's sarcoma associated herpesvirus (KSHV), like all herpesviruses maintains lifelong persistence with its host genome in latently infected cells with only a small fraction of cells showing signatures of productive lytic replication. Modulation o
Externí odkaz:
https://doaj.org/article/8396c47177b7425a9c05b554a87d5fd2
Autor:
Fengchao Lang, Rajnish Kumar Singh, Yonggang Pei, Shengwei Zhang, Kunfeng Sun, Erle S Robertson
Publikováno v:
PLoS Pathogens, Vol 15, Iss 6, p e1007796 (2019)
Epstein-Barr virus (EBV) is a ubiquitous oncogenic virus that induces many cancers. N6-Methyladenosine (m6A) modification regulates many cellular processes. We explored the role of m6A in EBV gene regulation and associated cancers. We have comprehens
Externí odkaz:
https://doaj.org/article/3e8ca476f6d04d2f9e08e0e7706febd8
Autor:
Fengchao Lang, Zhiguo Sun, Yonggang Pei, Rajnish Kumar Singh, Hem Chandra Jha, Erle S Robertson
Publikováno v:
PLoS Pathogens, Vol 15, Iss 4, p e1007732 (2019)
[This corrects the article DOI: 10.1371/journal.ppat.1007253.].
Externí odkaz:
https://doaj.org/article/f83fcba155724f059f90e8daf3e67953
Autor:
Shengwei Zhang, Yonggang Pei, Fengchao Lang, Kunfeng Sun, Rajnish Kumar Singh, Zachary L Lamplugh, Abhik Saha, Erle S Robertson
Publikováno v:
PLoS Pathogens, Vol 15, Iss 1, p e1007514 (2019)
EBV latent antigen 3C (EBNA3C) is essential for EBV-induced primary B-cell transformation. Infection by EBV induces hypermethylation of a number of tumor suppressor genes, which contributes to the development of human cancers. The Ras association dom
Externí odkaz:
https://doaj.org/article/e560d5532aec4e76b872e9123a657c68
Autor:
Fengchao Lang, Zhiguo Sun, Yonggang Pei, Rajnish Kumar Singh, Hem Chandra Jha, Erle S Robertson
Publikováno v:
PLoS Pathogens, Vol 14, Iss 9, p e1007253 (2018)
Shugoshin-1 (Sgo1) protects the integrity of the centromeres, and H2A phosphorylation is critical for this process. The mitotic checkpoint kinase Bub1, phosphorylates H2A and ensures fidelity of chromosome segregation and chromosome number. Oncogenic
Externí odkaz:
https://doaj.org/article/28eecd21834f47e5bff39cc452f15acc
Publikováno v:
PLoS Pathogens, Vol 14, Iss 5, p e1007062 (2018)
Kaposi's sarcoma associated herpesvirus (KSHV) infection stabilizes hypoxia inducible factors (HIFs). The interaction between KSHV encoded factors and HIFs plays a critical role in KSHV latency, reactivation and associated disease phenotypes. Besides
Externí odkaz:
https://doaj.org/article/149e62ae399243a7bf6d02a83b134c4f
Publikováno v:
PLoS Pathogens, Vol 13, Iss 7, p e1006500 (2017)
The latent EBV nuclear antigen 3C (EBNA3C) is required for transformation of primary human B lymphocytes. Most mature B-cell malignancies originate from malignant transformation of germinal center (GC) B-cells. The GC reaction appears to have a role
Externí odkaz:
https://doaj.org/article/43776b7df17d483a89fd1de126db8c8c
Autor:
Chong Wang, Caixia Zhu, Fang Wei, Shujun Gao, Liming Zhang, Yuhong Li, Yanling Feng, Yin Tong, Jianqing Xu, Bin Wang, Zhenghong Yuan, Erle S Robertson, Qiliang Cai
Publikováno v:
PLoS Pathogens, Vol 13, Iss 1, p e1006124 (2017)
Emerging evidence implies that STAT6 plays an important role in both the adaptive and innate immune responses to virus infection. Kaposi's sarcoma-associated herpesvirus (KSHV) is an oncogenic γ-herpesvirus agent associated with several human malign
Externí odkaz:
https://doaj.org/article/e1d381ed20bf43d09619fa8eb5ba837e