Zobrazeno 1 - 10
of 544
pro vyhledávání: '"Erkki Ruoslahti"'
Autor:
Horacio Maldonado, Bryan D. Savage, Harlan R. Barker, Ulrike May, Maria Vähätupa, Rahul K. Badiani, Katarzyna I. Wolanska, Craig M. J. Turner, Toini Pemmari, Tuomo Ketomäki, Stuart Prince, Martin J. Humphries, Erkki Ruoslahti, Mark R. Morgan, Tero A. H. Järvinen
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-23 (2023)
Abstract CAR (CARSKNKDC) is a wound-homing peptide that recognises angiogenic neovessels. Here we discover that systemically administered CAR peptide has inherent ability to promote wound healing: wounds close and re-epithelialise faster in CAR-treat
Externí odkaz:
https://doaj.org/article/81d0cec49afd4ba18434b1f1d9ec4d51
Autor:
Horacio Maldonado, Bryan D. Savage, Harlan R. Barker, Ulrike May, Maria Vähätupa, Rahul K. Badiani, Katarzyna I. Wolanska, Craig M. J. Turner, Toini Pemmari, Tuomo Ketomäki, Stuart Prince, Martin J. Humphries, Erkki Ruoslahti, Mark R. Morgan, Tero A. H. Järvinen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/ca3547e153b043ddb4d6cd82cb7b32a0
Autor:
Tatiana Hurtado de Mendoza, Evangeline S. Mose, Gregory P. Botta, Gary B. Braun, Venkata R. Kotamraju, Randall P. French, Kodai Suzuki, Norio Miyamura, Tambet Teesalu, Erkki Ruoslahti, Andrew M. Lowy, Kazuki N. Sugahara
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
The iRGD tumor-penetrating peptide can achieve tumor specific drug delivery but whether and how it can penetrate into desmoplastic tumors is unknown. Here, the authors show that β5 integrin expression on tumor cells, mediated by CAFs-derived TGF-β,
Externí odkaz:
https://doaj.org/article/80f9f85745054067b544050e7b18b670
Autor:
Jason V. Gregory, Padma Kadiyala, Robert Doherty, Melissa Cadena, Samer Habeel, Erkki Ruoslahti, Pedro R. Lowenstein, Maria G. Castro, Joerg Lahann
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
The lack of effective drug delivery strategies has impaired the therapeutic progress in the treatment of glioblastoma (GBM). Here, the authors engineer synthetic protein nanoparticle based on polymerized human serum albumin equipped with the cell-pen
Externí odkaz:
https://doaj.org/article/b30c04bdef1f4073bda6bbf46a097b78
Autor:
Yen Ling Yeow, Venkata Ramana Kotamraju, Xiao Wang, Meenu Chopra, Nasibah Azme, Jiansha Wu, Tobias D Schoep, Derek S Delaney, Kirk Feindel, Ji Li, Kelsey M Kennedy, Wes M Allen, Brendan F Kennedy, Irma Larma, David D Sampson, Lisa M Mahakian, Brett Z Fite, Hua Zhang, Tomas Friman, Aman P Mann, Farah A Aziz, M Priyanthi Kumarasinghe, Mikael Johansson, Hooi C Ee, George Yeoh, Lingjun Mou, Katherine W Ferrara, Hector Billiran, Ruth Ganss, Erkki Ruoslahti, Juliana Hamzah
Publikováno v:
EMBO Molecular Medicine, Vol 11, Iss 12, Pp 1-20 (2019)
Abstract High extracellular matrix (ECM) content in solid cancers impairs tumour perfusion and thus access of imaging and therapeutic agents. We have devised a new approach to degrade tumour ECM, which improves uptake of circulating compounds. We tar
Externí odkaz:
https://doaj.org/article/2e2437d4c1094f77b0d61ca7df6fa756
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
In the context of increasing bacterial antibiotic-resistance, gene therapy that targets the immune system to clear infection is a major goal. Here the authors show a silicon based nanosystem that modulates the macrophage response in an in vivo model
Externí odkaz:
https://doaj.org/article/098171d737834a66a71effee6e976c20
Autor:
Aman P. Mann, Pablo Scodeller, Sazid Hussain, Gary B. Braun, Tarmo Mölder, Kadri Toome, Rajesh Ambasudhan, Tambet Teesalu, Stuart A. Lipton, Erkki Ruoslahti
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Cerebrovascular changes and astrogliosis occur in Alzheimer’s disease (AD). Using an in vivo phage display technique, the authors identified a peptide that upon systematic administration, can home to brain endothelial cells and astrocytes in mouse
Externí odkaz:
https://doaj.org/article/be95d3c6783044f889e270600ff9b0e4
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
The imaging of tumors in vivo using nanoprobes has been challenging due to the lack of sufficient tumor specificity. Here, the authors develop a tumor-specific quantum dot system that permits in vivo cation exchange to achieve selective background qu
Externí odkaz:
https://doaj.org/article/4d743ca645be4dcdb910f31cf2136739
Autor:
Aman P. Mann, Pablo Scodeller, Sazid Hussain, Jinmyoung Joo, Ester Kwon, Gary B. Braun, Tarmo Mölder, Zhi-Gang She, Venkata Ramana Kotamraju, Barbara Ranscht, Stan Krajewski, Tambet Teesalu, Sangeeta Bhatia, Michael J. Sailor, Erkki Ruoslahti
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
Accurate treatment of traumatic brain injuries, a leading cause of neurological disability and death in young people, is hampered by poor accumulation of drugs in the brain. Here, the authors describe a tetrapeptide that can efficiently target brain
Externí odkaz:
https://doaj.org/article/9ba4b22334aa479f9406152857335901
Autor:
Venkata Ramana Kotamraju, Shweta Sharma, Poornima Kolhar, Lilach Agemy, James Pavlovich, Erkki Ruoslahti
Publikováno v:
Breast Cancer: Basic and Clinical Research, Vol 2015, Iss Suppl. 2, Pp 79-87 (2016)
Externí odkaz:
https://doaj.org/article/3dfb5f5a7b574cf685e053dc068046e2