Supplemental Table 1 from Targeting IL11 Receptor in Leukemia and Lymphoma: A Functional Ligand-Directed Study and Hematopathology Analysis of Patient-Derived Specimens

Autor: Renata Pasqualini, Wadih Arap, Erkki Koivunen, George A. Calin, Jorge E. Cortes, Hagop M. Kantarjian, Susan O'Brien, Amado J. Zurita, Cecilia Rietz, Marina Cardó-Vila, Wouter H.P. Driessen, Akihiko Kuniyasu, Yan Sun, Laura Bover, Carlos Bueso-Ramos, Diana E. Jaalouk, Katja Karjalainen

Supplemental Table 1. Features of synthesized analogs of BMTP-11 for drug-lead optimization.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83c5291e96a286cefc60d9c7ee0cd1f8
https://doi.org/10.1158/1078-0432.22457769

Supplemental Figure 3 from Targeting IL11 Receptor in Leukemia and Lymphoma: A Functional Ligand-Directed Study and Hematopathology Analysis of Patient-Derived Specimens

Autor: Renata Pasqualini, Wadih Arap, Erkki Koivunen, George A. Calin, Jorge E. Cortes, Hagop M. Kantarjian, Susan O'Brien, Amado J. Zurita, Cecilia Rietz, Marina Cardó-Vila, Wouter H.P. Driessen, Akihiko Kuniyasu, Yan Sun, Laura Bover, Carlos Bueso-Ramos, Diana E. Jaalouk, Katja Karjalainen

Supplemental Figure 3. Drug activity of BMTP-11 and BMTP#4 on a panel of established leukemia and lymphoma cell lines.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::407d760b0e8f320ca5df7d83737e63e5
https://doi.org/10.1158/1078-0432.22457775

Supplemental Figure 2 from Targeting IL11 Receptor in Leukemia and Lymphoma: A Functional Ligand-Directed Study and Hematopathology Analysis of Patient-Derived Specimens

Autor: Renata Pasqualini, Wadih Arap, Erkki Koivunen, George A. Calin, Jorge E. Cortes, Hagop M. Kantarjian, Susan O'Brien, Amado J. Zurita, Cecilia Rietz, Marina Cardó-Vila, Wouter H.P. Driessen, Akihiko Kuniyasu, Yan Sun, Laura Bover, Carlos Bueso-Ramos, Diana E. Jaalouk, Katja Karjalainen

Supplemental Figure 2. Cell membrane and cytoplasmic expression of IL-11R.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b61d03b914c96651b8ebfb951a2b7085
https://doi.org/10.1158/1078-0432.22457778.v1

Therapeutic targeting of membrane-associated GRP78 in leukemia and lymphoma: preclinical efficacy in vitro and formal toxicity study of BMTP-78 in rodents and primates

Autor: Geetanjali Sharma, Wallace B. Baze, Fortunato Ferrara, Tracey L. Smith, Richard L. Sidman, Erkki Koivunen, Daniela I. Staquicini, Patrick W. Hanley, Sara D'Angelo, Kirstin F. Barnhart, Serena Marchiò, Renata Pasqualini, Christy A. Tarleton, Wadih Arap, Akihiko Kuniyasu, Katja Karjalainen, Diana E. Jaalouk, B. K. Chaffee, Hagop M. Kantarjian, Jorge E. Cortes

Translation of drug candidates into clinical settings requires demonstration of preclinical efficacy and formal toxicology analysis for filling an Investigational New Drug (IND) application with the US Food and Drug Administration (FDA). Here, we inv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb7be92f8d97a57c05c9cc0ce3cb1f97
http://hdl.handle.net/2318/1658356

Cooperative effects of aminopeptidase N (CD13) expressed by nonmalignant and cancer cells within the tumor microenvironment

Autor: Liliana Guzman-Rojas, Eleonora Dondossola, Yun-Gon Kim, Wadih Arap, Mikhail G. Kolonin, Roberto Rangel, Erkki Koivunen, Richard L. Sidman, Fernanda I. Staquicini, Renata Pasqualini, Ricardo J. Giordano, Julianna K. Edwards, Ahmad Salameh, Alan Saghatelian

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Processes that promote cancer progression such as angiogenesis require a functional interplay between malignant and nonmalignant cells in the tumor microenvironment. The metalloprotease aminopeptidase N (APN; CD13) is often overexpressed in tumor cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37822711b11f10015afe48a86a02397f
https://doi.org/10.1073/pnas.1120790109