Phase 1 Lymfactin® Study : 24-month Efficacy and Safety Results of Combined Adenoviral VEGF-C and Lymph Node Transfer Treatment for Upper Extremity Lymphedema

Autor: Ida-Maria Leppäpuska, Pauliina Hartiala, Sinikka Suominen, Erkki Suominen, Ilkka Kaartinen, Maija Mäki, Marko Seppänen, Juha Kiiski, Tiina Viitanen, Outi Lahdenperä, Antti Vuolanto, Kari Alitalo, Anne M. Saarikko

BACKGROUND: Lymphedema is a common problem after breast cancer treatment. Lymfactin (R) is a prolymphangiogenic growth factor vector inducing the expression of human vascular endothelial growth factor C (VEGF-C). It promotes growth and repair of lymp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::359cfc4bae98b8c6d7ee03e503269cf4
https://trepo.tuni.fi/handle/10024/145148

Long-term Results of Microvascular Lymph Node Transfer: Correlation of Preoperative Factors and Operation Outcome

Autor: Sinikka Suominen, Erkki Suominen, Anne Saarikko, Tiina P. Viitanen, Pauliina Hartiala, Maija Mäki, Eeva H. Rannikko, Marko Seppänen

Publikováno v: Plastic and Reconstructive Surgery, Global Open, Vol 9, Iss 1, p e3354 (2021)
Plastic and Reconstructive Surgery Global Open

Background: Our objective was to analyze whether a correlation could be observed between preoperative factors and microvascular lymph node transfer outcome after long-term follow-up. Methods: We included 67 patients in this retrospective case series.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6af37721fddd5d7b8c221a8174961107
http://journals.lww.com/prsgo/fulltext/10.1097/GOX.0000000000003354

Analysis of Fat Graft Metabolic Adaptation and Vascularization Using Positron Emission Tomography–Computed Tomographic Imaging

Autor: Pirjo Nuutila, Anne Saarikko, Henna Karra, Tomi V. Tervala, Seppo Ylä-Herttuala, Tove J. Grönroos, Pauliina Hartiala, Erkki Suominen, Katri Kivinen

Publikováno v: Plastic and Reconstructive Surgery. 133:291-299

BACKGROUND Fat tissue transfer is commonly used for different soft-tissue defects in surgery. The immediate result of these operations is often good, but the long-term result is unfortunately unpredictable. The authors used an experimental model to e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d7c3200ee035f431e7a9d5ce37d67cc
https://doi.org/10.1097/01.prs.0000436839.62128.3b

Lymphatic Vessel Function and Lymphatic Growth Factor Secretion after Microvascular Lymph Node Transfer in Lymphedema Patients

Autor: Marko P. Seppänen, Mikko T. Visuri, Tiina P. Viitanen, Pauliina Hartiala, Anne Saaristo, Maija Mäki, Erkki Suominen

Publikováno v: Plastic and Reconstructive Surgery, Global Open, Vol 1, Iss 2, Pp 1-9 (2013)
Plastic and Reconstructive Surgery Global Open

Chronic lymphedema remains a challenging problem that often lacks curative treatment options. The incidence of lymphedema varies from 9% to 41% in patients who have undergone axillary lymph node dissection and from 4% to 10% in patients who have unde

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc1e7632b1ca68cbddfe08973347a85d
https://doi.org/10.1097/gox.0b013e318293a532

Hailey-Hailey disease and tight junctions: Claudins 1 and 4 are regulated by ATP2C1 gene encoding Ca2+/Mn2+ATPase SPCA1 in cultured keratinocytes

Autor: Laura Raiko, Mỹ G. Mahoney, Erkki Suominen, Heli Putaala, Juha Peltonen, Sirkku Peltonen, Elina Siljamäki

Publikováno v: Experimental Dermatology. 21:586-591

Mutations in the ATP2C1 gene encoding Ca(2+) /Mn(2+) ATPase SPCA1 cause Hailey-Hailey disease (HHD, OMIM 16960). HHD is characterized by epidermal acantholysis. We attempted to model HHD using normal keratinocytes, in which the SPCA1 mRNA was down-re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6456b866ce1fc1edfbd7824c086a11af
https://doi.org/10.1111/j.1600-0625.2012.01520.x