Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Erkki, Kuusisto"'
Autor:
Pauliina Korhonen, Erkki Kuusisto, Tiina Suuronen, Maaria Roschier, Sergiy Kyrylenko, Antero Salminen
Publikováno v:
Journal of Neurochemistry. 76:11-20
Neuronal apoptosis is considered to play a significant role in several neuropathological conditions. However, the molecular mechanisms underlying neuronal apoptosis are poorly understood. Insulin-like growth factor (IGF) signalling is considered to b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::456f6131e2b2e9e8897f56509d268f74
https://doi.org/10.1046/j.1471-4159.2001.00002.x
https://doi.org/10.1046/j.1471-4159.2001.00002.x
Publikováno v:
Biochemical and Biophysical Research Communications. 280:223-228
Neuronal apoptosis is involved in several pathological conditions of the brain. Using cDNA arrays, we observed upregulation of ubiquitin-binding protein p62 expression during serum withdrawal-induced apoptosis in Neuro-2a cells. We demonstrate here t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f538cb8a0448245e2d365462db2888d
https://doi.org/10.1006/bbrc.2000.4107
https://doi.org/10.1006/bbrc.2000.4107
Expression of Seizure-Related PTZ-17 Is Induced by Potassium Deprivation in Cerebellar Granule Cells
Publikováno v:
Biochemical and Biophysical Research Communications. 252:10-13
The aim of this study was to identify changes in gene expression during neuronal apoptosis using the differential display (DD) technique. Potassium deprivation was used to induce neuronal apoptosis in cultured rat cerebellar granule cells. DD analysi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e6f5866c3bcbea234f7744782836f31
https://doi.org/10.1006/bbrc.1998.9589
https://doi.org/10.1006/bbrc.1998.9589
Autor:
Erkki Kuusisto, Antti Poso, Tiina Suuronen, Jukka Leppänen, Päivi H. Kiviranta, Anu J. Tervo, Sergiy Kyrylenko, Antero Salminen
Publikováno v:
Journal of Medicinal Chemistry. 49:7239-7241
A successful virtual screening experiment of novel SIRT2 inhibitors is described. Four out of 11 experimentally tested compounds showed in vitro inhibitory activity toward SIRT2 in a micromolar level, resulting in an experimental hit ratio of 36%. Tw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39b0f89f6086d2774c2b8f94ae311555
https://doi.org/10.1021/jm060686r
https://doi.org/10.1021/jm060686r
Autor:
Johanna, Viiri, Juha M T, Hyttinen, Tuomas, Ryhänen, Kirsi, Rilla, Tuomas, Paimela, Erkki, Kuusisto, Ari, Siitonen, Arto, Urtti, Antero, Salminen, Kai, Kaarniranta
Publikováno v:
Molecular Vision
Purpose The pathogenesis of age-related macular degeneration involves impaired protein degradation in retinal pigment epithelial (RPE) cells. The ubiquitin-proteasome pathway and the lysosomal pathway including autophagy are the major proteolytic sys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a47a99ff9ecf08895ab348ce1802efd8
https://pubmed.ncbi.nlm.nih.gov/20680098
https://pubmed.ncbi.nlm.nih.gov/20680098
Autor:
Juergen Kopitz, Ilkka Immonen, Antero Salminen, Eeva-Liisa Eskelinen, Tuomas Ryhänen, Erkki Kuusisto, Johanna Viiri, Kai Kaarniranta, Carina I. Holmberg, Juha M.T. Hyttinen, Seppo Meri, Kirsi Rilla, Jussi Parkkinen, Hannu Uusitalo, Eliisa Mannermaa
Publikováno v:
Journal of Cellular and Molecular Medicine
The pathogenesis of age-related macular degeneration involves chronic oxidative stress, impaired degradation of membranous discs shed from photoreceptor outer segments and accumulation of lysosomal lipofuscin in retinal pigment epithelial (RPE) cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64f43fd015c33a81fa1f945e79ee32d4
https://pubmed.ncbi.nlm.nih.gov/19017362
https://pubmed.ncbi.nlm.nih.gov/19017362
Autor:
Tiina Suuronen, Päivi H. Kiviranta, Sergiy Kyrylenko, Valtteri M. Rinne, Erkki Kuusisto, Maija Lahtela-Kakkonen, Antti Poso, Erik A.A. Wallén, Antero Salminen, Heikki S. Salo, Jukka Leppänen
Publikováno v:
Bioorganicmedicinal chemistry. 16(17)
SIRT2 inhibitors with a N-(3-phenylpropenoyl)-glycine tryptamide backbone were studied. This backbone has been developed in our group, and it is derived from a compound originally found by virtual screening. In addition, compounds with a smaller 3-ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::249c7253632dab6a78dfe4b3d4e3380e
https://pubmed.ncbi.nlm.nih.gov/18701307
https://pubmed.ncbi.nlm.nih.gov/18701307
Publikováno v:
Neuropathology and applied neurobiology. 34(2)
The demonstration of proteinaceous inclusions in the brain is the key step in the pathological diagnosis of degenerative dementias. The diversity of these diseases has necessitated the use of a panel of (immuno)stains to visualize all suspect patholo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4ad2035562457ecf6c7770c6b4bfe25
https://pubmed.ncbi.nlm.nih.gov/17961133
https://pubmed.ncbi.nlm.nih.gov/17961133
Autor:
Valtteri M. Rinne, Tiina Suuronen, Olga Kyrylenko, Päivi H. Kiviranta, Anu J. Tervo, Antti Poso, Tomi Järvinen, Jukka Leppänen, Erik A.A. Wallén, Antero Salminen, Sergiy Kyrylenko, Erkki Kuusisto
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(9)
A series of N-(3-(4-hydroxyphenyl)-propenoyl)-amino acid tryptamides was based on a previously reported new SIRT2 inhibitor from our group, and it was designed to study if the molecular size of the compound could be reduced. The most potent compounds
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a883286f6108a6d4ce72f6f8ca6567b9
https://pubmed.ncbi.nlm.nih.gov/17329104
https://pubmed.ncbi.nlm.nih.gov/17329104
Publikováno v:
Journal of neuropathology and experimental neurology. 62(12)
The formation of Lewy bodies (LBs) and their relationship to other types of nigral inclusions associated with Parkinson disease (PD), such as pale bodies (PBs), remain poorly understood. Known constituents of LBs include alpha-synuclein (alphaS) and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c09fc946cd97146705ff88e523f4c245
https://pubmed.ncbi.nlm.nih.gov/14692700
https://pubmed.ncbi.nlm.nih.gov/14692700