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Akademický článek

Medication profiling in women with type 1 diabetes highlights the importance of adequate, guideline-based treatment in low-risk groups

Autor: Raija Lithovius, Stefan Mutter, Erika B. Parente, Ville-Petteri Mäkinen, Erkka Valo, Valma Harjutsalo, Per-Henrik Groop

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-9 (2023)

Abstract Effective treatment may prevent kidney complications, but women might be underprescribed. Novel, data-driven insights into prescriptions and their relationship with kidney health in women with type 1 diabetes may help to optimize treatment.

Externí odkaz: https://doaj.org/article/074ee5f0fe95407f81830aad23bb8f80

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Akademický článek

Whole-exome sequencing identifies novel protein-altering variants associated with serum apolipoprotein and lipid concentrations

Autor: Niina Sandholm, Ronja Hotakainen, Jani K. Haukka, Fanny Jansson Sigfrids, Emma H. Dahlström, Anni A. Antikainen, Erkka Valo, Anna Syreeni, Elina Kilpeläinen, Anastasia Kytölä, Aarno Palotie, Valma Harjutsalo, Carol Forsblom, Per-Henrik Groop, on behalf of the FinnDiane Study Group

Publikováno v: Genome Medicine, Vol 14, Iss 1, Pp 1-18 (2022)

Abstract Background Dyslipidemia is a major risk factor for cardiovascular disease, and diabetes impacts the lipid metabolism through multiple pathways. In addition to the standard lipid measurements, apolipoprotein concentrations provide added aware

Externí odkaz: https://doaj.org/article/3656e2df02434cbca5a5f1c25c95cd07

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Akademický článek

Genome-wide mRNA profiling in urinary extracellular vesicles reveals stress gene signature for diabetic kidney disease

Autor: Om Prakash Dwivedi, Karina Barreiro, Annemari Käräjämäki, Erkka Valo, Anil K. Giri, Rashmi B. Prasad, Rishi Das Roy, Lena M. Thorn, Antti Rannikko, Harry Holthöfer, Kim M. Gooding, Steven Sourbron, Denis Delic, Maria F. Gomez, Per-Henrik Groop, Tiinamaija Tuomi, Carol Forsblom, Leif Groop, Maija Puhka

Publikováno v: iScience, Vol 26, Iss 5, Pp 106686- (2023)

Summary: Urinary extracellular vesicles (uEV) are a largely unexplored source of kidney-derived mRNAs with potential to serve as a liquid kidney biopsy. We assessed ∼200 uEV mRNA samples from clinical studies by genome-wide sequencing to discover m

Externí odkaz: https://doaj.org/article/5b53c14dd8ee490b811a4f2dffd31175

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Akademický článek

Effect of serum sample storage temperature on metabolomic and proteomic biomarkers

Autor: Erkka Valo, Marco Colombo, Niina Sandholm, Stuart J. McGurnaghan, Luke A. K. Blackbourn, David B. Dunger, Paul M. McKeigue, Carol Forsblom, Per-Henrik Groop, Helen M. Colhoun, Charles Turner, R. Neil Dalton

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)

Abstract Prospective biomarker studies can be used to identify biomarkers predictive of disease onset. However, if serum biomarkers are measured years after their collection, the storage conditions might affect analyte concentrations. Few data exists

Externí odkaz: https://doaj.org/article/b58b42738bbf4bd599e01cbd8dcbc87c

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Akademický článek

Confirmation of GLRA3 as a susceptibility locus for albuminuria in Finnish patients with type 1 diabetes

Autor: Niina Sandholm, Jani K Haukka, Iiro Toppila, Erkka Valo, Valma Harjutsalo, Carol Forsblom, Per-Henrik Groop

Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-8 (2018)

Abstract Urinary albumin excretion is an early sign of diabetic kidney disease, affecting every third individual with diabetes. Despite substantial estimated heritability, only variants in the GLRA3 gene have been genome-wide significantly associated

Externí odkaz: https://doaj.org/article/86e9a250dc08488f9a5488cfa33be9b5

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