Zobrazeno 1 - 10
of 145
pro vyhledávání: '"Erkang, Fan"'
Autor:
Maria Cristina Ferreira de Sousa, Dennis Imhof, Kai Pascal Alexander Hänggeli, Ryan Choi, Matthew A. Hulverson, Samuel L.M. Arnold, Wesley C. Van Voorhis, Erkang Fan, Sánchez-Sánchez Roberto, Luis M. Ortega-Mora, Andrew Hemphill
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 25, Iss , Pp 100553- (2024)
Toxoplasma gondii and Neospora caninum are major worldwide morbidity-causing pathogens. Bumped kinase inhibitors (BKIs) are a compound class that has been optimized to target the apicomplexan calcium-dependent protein kinase 1 (CDPK1) – and several
Externí odkaz:
https://doaj.org/article/5d45770ad7984b1f80ca4e9a68cdce54
Autor:
Matthew A. Hulverson, Ryan Choi, Deborah A. Schaefer, Dana P. Betzer, Molly C. McCloskey, Grant R. Whitman, Wenlin Huang, Sangun Lee, Andy Pranata, Malcolm D. McLeod, Kennan C. Marsh, Dale J. Kempf, Bruce E. LeRoy, Mark T. Zafiratos, Aimee L. Bielinski, Robert C. Hackman, Kayode K. Ojo, Samuel L. M. Arnold, Lynn K. Barrett, Saul Tzipori, Michael W. Riggs, Erkang Fan, Wesley C. Van Voorhis
Publikováno v:
Antimicrobial Agents and Chemotherapy. 67
Recent advances on the development of bumped kinase inhibitors for treatment of cryptosporidiosis have focused on the 5-aminopyrazole-4-carboxamide scaffold, due to analogs that have less hERG inhibition, superior efficacy, and strong in vitro safety
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::61032458b2e188a2d38735d1346d5132
https://doi.org/10.1128/aac.01425-22
https://doi.org/10.1128/aac.01425-22
Autor:
Kayode K Ojo, Ranae M Ranade, Zhongsheng Zhang, David M Dranow, Janette B Myers, Ryan Choi, Steve Nakazawa Hewitt, Thomas E Edwards, Douglas R Davies, Donald Lorimer, Stephen M Boyle, Lynn K Barrett, Frederick S Buckner, Erkang Fan, Wesley C Van Voorhis
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0160350 (2016)
We investigated Brucella melitensis methionyl-tRNA-synthetase (BmMetRS) with molecular, structural and phenotypic methods to learn if BmMetRS is a promising target for brucellosis drug development. Recombinant BmMetRS was expressed, purified from wil
Externí odkaz:
https://doaj.org/article/cb7e4a5c4ce4461f81768815566850e3
Autor:
Kayode K Ojo, Ranae M Ranade, Zhongsheng Zhang, David M Dranow, Janette B Myers, Ryan Choi, Steve Nakazawa Hewitt, Thomas E Edwards, Douglas R Davies, Donald Lorimer, Stephen M Boyle, Lynn K Barrett, Frederick S Buckner, Erkang Fan, Wesley C Van Voorhis
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0163641 (2016)
[This corrects the article DOI: 10.1371/journal.pone.0160350.].
Externí odkaz:
https://doaj.org/article/c92c1f2c13354f3b8fd19714b3ea1027
Autor:
Ryan Choi, Peter S. Horanyi, David M. Dranow, Zhongsheng Zhang, Thomas E. Edwards, Kayode K. Ojo, Donald D. Lorimer, Peter J. Myler, Kevin Hybiske, Wesley C. Van Voorhis, Logan Tillery, Edelmar D. Navaluna, Sandhya Subramanian, Bart Staker, Samantha A. Michaels, Lynn K. Barrett, Shareef Shaheen, Olusegun O. Soge, Justin K. Craig, Kayleigh F. Barrett, Jan Abendroth, Isabelle Q. Phan, Erkang Fan, Deborah G. Conrady
Publikováno v:
Protein Sci
Neisseria gonorrhoeae (Ng) and Chlamydia trachomatis (Ct) are the most commonly reported sexually transmitted bacteria worldwide and usually present as co-infections. Increasing resistance of Ng to currently recommended dual therapy of azithromycin a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17ec131444ebc7d33a02c904c8a51b75
https://doi.org/10.1002/pro.3824
https://doi.org/10.1002/pro.3824
Autor:
Ryan Choi, Wesley C. Van Voorhis, Grant R. Whitman, Zhongsheng Zhang, Kayode K. Ojo, Wenlin Huang, Molly C. McCloskey, Lynn K. Barrett, Robert C. Hackman, Samuel L.M. Arnold, Kasey Rivas, Erkang Fan, Matthew A. Hulverson
Publikováno v:
Journal of Medicinal Chemistry. 62:3135-3146
Cryptosporidium is a leading cause of pediatric diarrhea worldwide. Currently there is neither a vaccine nor a consistently effective drug available for this disease. Selective 5-aminopyrazole-4-carboxamide-based bumped-kinase inhibitors (BKIs) are e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7863df51de4d643de4abd6950dc3ce76
https://doi.org/10.1021/acs.jmedchem.9b00069
https://doi.org/10.1021/acs.jmedchem.9b00069
Autor:
Cho Yeow Koh, Jessica E Kim, Allan B Wetzel, Will J de van der Schueren, Sayaka Shibata, Ranae M Ranade, Jiyun Liu, Zhongsheng Zhang, J Robert Gillespie, Frederick S Buckner, Christophe L M J Verlinde, Erkang Fan, Wim G J Hol
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 8, Iss 4, p e2775 (2014)
Methionyl-tRNA synthetase of Trypanosoma brucei (TbMetRS) is an important target in the development of new antitrypanosomal drugs. The enzyme is essential, highly flexible and displaying a large degree of changes in protein domains and binding pocket
Externí odkaz:
https://doaj.org/article/d5d82033472f498782042305c840c109
Autor:
Kayode K Ojo, Molly C Reid, Latha Kallur Siddaramaiah, Joachim Müller, Pablo Winzer, Zhongsheng Zhang, Katelyn R Keyloun, Rama Subba Rao Vidadala, Ethan A Merritt, Wim G J Hol, Dustin J Maly, Erkang Fan, Wesley C Van Voorhis, Andrew Hemphill
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e92929 (2014)
Despite the enormous economic importance of Neospora caninum related veterinary diseases, the number of effective therapeutic agents is relatively small. Development of new therapeutic strategies to combat the economic impact of neosporosis remains a
Externí odkaz:
https://doaj.org/article/d64eee0005e046cc9e4cbb234e0d589e
Autor:
Erkang Fan, Jose E. Teixeira, Adam Sateriale, Christopher D. Huston, John R. Gillespie, Peter Jonathon Miller, Muhammad M. Hasan, Erin E. Stebbins, Frederick S. Buckner, Zhongsheng Zhang, Robert K. M. Choy, Christophe L. M. J. Verlinde, Ranae M. Ranade, Eugenio L. de Hostos, Aisha Mushtaq, Damon M. Osbourn, David W. Griggs
Publikováno v:
Antimicrob Agents Chemother
The intestinal protozoan Cryptosporidium is a leading cause of diarrheal disease and mortality in young children. There is currently no fully effective treatment for cryptosporidiosis, which has stimulated interest in anticryptosporidial development
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec9d4e0b2a43263d5bede9707a02798d
https://doi.org/10.1128/aac.00023-21
https://doi.org/10.1128/aac.00023-21
Autor:
Dennis Imhof, Kayode K. Ojo, Pablo Winzer, Joachim Müller, Samuel L.M. Arnold, Lynn K. Barrett, Thomas J. Kennedy, J. Stone Doggett, Nicoleta Anghel, Deborah A. Schaefer, Sangun Lee, Saul Tzipori, Wesley C. Van Voorhis, Roberto Sánchez-Sánchez, Grant R. Whitman, Luis Miguel Ortega-Mora, Ignacio Ferre, Wenlin Huang, Andrew Hemphill, Dustin J. Maly, Rama Subba Rao Vidadala, Michael W. Riggs, Erkang Fan, Matthew A. Hulverson, Ryan Choi, Dana P. Betzer
Publikováno v:
Vet Parasitol
This is a review of the development of bumped-kinase inhibitors (BKIs) for the therapy of One Health parasitic apicomplexan diseases. Many apicomplexan infections are shared between humans and livestock, such as cryptosporidiosis and toxoplasmosis, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6d56f9f2592749b7fe060ddec917bcb
https://pubmed.ncbi.nlm.nih.gov/33418437
https://pubmed.ncbi.nlm.nih.gov/33418437