Zobrazeno 1 - 10
of 501
pro vyhledávání: '"Erk phosphorylation"'
Autor:
Lan Phuong Nguyen, Minyeong Cho, Thai Uy Nguyen, Hee-Kyung Park, Huong Thi Nguyen, Kateryna Mykhailova, Sunghoon Hurh, Hong-Rae Kim, Jae Young Seong, Cheol Soon Lee, Byung-Joo Ham, Jong-Ik Hwang
Publikováno v:
Cell & Bioscience, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract Background Tachykinins and their cognate receptors, neurokinin receptors (NKs) including NK1, NK2, and NK3 play vital roles in regulating various physiological processes including neurotransmission, nociception, inflammation, smooth muscle c
Externí odkaz:
https://doaj.org/article/307d7b190b1740099026f1f1d0b3fcd4
Publikováno v:
Exploration of Neuroprotective Therapy, Vol 3, Iss 5, Pp 258-267 (2023)
Aim: The sequential phosphorylation of mitogen-activated protein (MAP) kinases MEK-ERK is the most relevant cellular signaling pathway. This study quantified the parallel in vivo regulation of brain phosphorylation-MEK1/2 (p-MEK1/2) to p-ERK1/2 by me
Externí odkaz:
https://doaj.org/article/df8d26269b3d437f9ba880e74e25584b
Publikováno v:
Molecular Medicine, Vol 29, Iss 1, Pp 1-15 (2023)
Abstract Background Glycine receptors (GlyRs) play key roles in the processing of inflammatory pain. The use of adeno-associated virus (AAV) vectors for gene therapy in human clinical trials has shown promise, as AAV generally causes a very mild immu
Externí odkaz:
https://doaj.org/article/bcd430bdf83342d9872acfc43797e0d6
Publikováno v:
Acta Biochimica et Biophysica Sinica, Vol 54, Pp 1917-1923 (2022)
Cefotetan is widely used to treat bacterial infections in the clinic owing to its broad spectrum of antibacterial activity. In the present study, we demonstrate that cefotetan can bind to the conserved ligand-binding pocket of human Raf1 kinase inhib
Externí odkaz:
https://doaj.org/article/b080d1137dda4c519357a93b4e6a1521
Autor:
Huizhi Sun, Jing Mo, Runfen Cheng, Fan Li, Yue Li, Yuhong Guo, Yanlei Li, Yanhui Zhang, Xiaoyu Bai, Yalei Wang, Xueyi Dong, Danfang Zhang, Jihui Hao
Publikováno v:
Cancer Biology & Medicine, Vol 19, Iss 11, Pp 1598-1616 (2022)
Objective: Hypoxia is an important feature of pancreatic ductal adenocarcinoma (PDAC). Previously, we found that hypoxia promotes ENO1 expression and PDAC invasion. However, the underlying molecular mechanism was remains unclear. Methods: The relatio
Externí odkaz:
https://doaj.org/article/353761a4dd4048a1b59236abeed331ee
Akademický článek
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Autor:
Run-Jing Li, Jia-Jia Xu, Zheng-Hao Zhang, Min-Wei Chen, Shi-Xiao Liu, Cui Yang, Yan-Ling Li, Ping Luo, Yi-Jiang Liu, Rong Tang, Zhong-Gui Shan
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
The progression from compensatory hypertrophy to heart failure is difficult to reverse, in part due to extracellular matrix fibrosis and continuous activation of abnormal signaling pathways. Although the anthraquinone rhein has been examined for its
Externí odkaz:
https://doaj.org/article/70a32215611e42deb7d416208073c24f
Publikováno v:
Biomolecules, Vol 12, Iss 12, p 1813 (2022)
The growth hormone secretagogue receptor-1a (GHSR1a) is the endogenous receptor for ghrelin. Activation of GHSR1a participates in many physiological processes including energy homeostasis and eating behavior. Due to its transitory half-life, the effi
Externí odkaz:
https://doaj.org/article/3bc05c91755c48acb8390696545551d4
Akademický článek
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Akademický článek
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