Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Eris Bame"'
Autor:
Eris Bame, Hao Tang, Jeremy C Burns, Million Arefayene, Klaus Michelsen, Bin Ma, Isaac Marx, Robin Prince, Allie M Roach, Urjana Poreci, Douglas Donaldson, Patrick Cullen, Fergal Casey, Jing Zhu, Thomas M Carlile, Dipen Sangurdekar, Baohong Zhang, Patrick Trapa, Joseph Santoro, Param Muragan, Alex Pellerin, Stephen Rubino, Davide Gianni, Bekim Bajrami, Xiaomei Peng, Alex Coppell, Katherine Riester, Shibeshih Belachew, Devangi Mehta, Mike Palte, Brian T Hopkins, Matthew Scaramozza, Nathalie Franchimont, Michael Mingueneau
Publikováno v:
Clinical & Translational Immunology, Vol 10, Iss 6, Pp n/a-n/a (2021)
Abstract Objectives Bruton's tyrosine kinase (BTK) plays a non‐redundant signaling role downstream of the B‐cell receptor (BCR) in B cells and the receptors for the Fc region of immunoglobulins (FcR) in myeloid cells. Here, we characterise BIIB09
Externí odkaz:
https://doaj.org/article/960649d0c0f948e3add268a6d5cc0401
Autor:
Mark Cascione, Chongshu Chen, Tomasz Zielinski, Catherine Miller, Becky Parks, David Brassat, Shivani Kapadia, Yang Mao-Draayer, Diana Xing, Derrick Robertson, Erin E. Longbrake, Eris Bame, Jason P. Mendoza
Publikováno v:
Multiple Sclerosis (Houndmills, Basingstoke, England)
Background: Delayed-release dimethyl fumarate (DMF) demonstrates sustained efficacy and safety for relapsing forms of MS. Absolute lymphocyte count (ALC) is reduced initially, then stabilizes on treatment. Objective: PROCLAIM, a 96-week, prospective,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a15bf246aa2e7f9fe55ef173852780aa
https://doi.org/10.1177/1352458520937282
https://doi.org/10.1177/1352458520937282
Autor:
Kevin L. Otipoby, Sarah Sheikh, Douglas Marcotte, George A. Moniz, Michael Humora, Brian T. Hopkins, Judy Bai, Karen Smirnakis, J. Michael Macphee, Tonika Bohnert, Timothy R. Chan, Devangi Mehta, Bin Ma, Million Arefayene, Zheng Fengmei, Lei Zhang, Patricia Schroeder, Annick Prefontaine, Eris Bame, Urjana Poreci, Evelyne Polack, Eric Tien, Claire M. Metrick, Bekim Bajrami
Publikováno v:
Journal of Medicinal Chemistry. 63:12526-12541
Autoreactive B cell-derived antibodies form immune complexes that likely play a pathogenic role in autoimmune diseases. In systemic lupus erythematosus (SLE), these antibodies bind Fc receptors on myeloid cells and induce proinflammatory cytokine pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7847a2561125cd5a06e20ac411c45701
https://doi.org/10.1021/acs.jmedchem.0c00702
https://doi.org/10.1021/acs.jmedchem.0c00702
Autor:
Steven Piccoli, Devangi Mehta, Alessandra Vitaliti, John Allinson, Shashi Amur, Steve Eck, Cherie Green, Michael Hedrick, Shirley Hopper, Allena Ji, Alison Joyce, Virginia Litwin, Kevin Maher, Joel Mathews, Kun Peng, Afshin Safavi, Yow-Ming Wang, Yan Zhang, Lakshmi Amaravadi, Nisha Palackal, Sai Thankamony, Chris Beaver, Eris Bame, Thomas Emrich, Christine Grimaldi, Jonathan Haulenbeek, Vellalore Kakkanaiah, David Lanham, Andrew Mayer, Paul C Trampont, Laurent Vermet, Naveen Dakappagari, Catherine Fleener, Fabio Garofolo, Cynthia Rogers, Shabnam Tangri, Yuanxin Xu, Meina Liang, Manoj Rajadhyaksha, Susan Richards, Becky Schweighardt, Shobha Purushothama, Daniel Baltrukonis, Jochen Brumm, Elana Cherry, Jason Delcarpini, Carol Gleason, Susan Kirshner, Robert Kubiak, Luying Pan, Michael Partridge, João Pedras-Vasconcelos, Qiang Qu, Venke Skibeli, Therese Solstad Saunders, Roland F Staack, Kay Stubenrauch, Al Torri, Daniela Verthelyi, Haoheng Yan, Boris Gorovits, Rachel Palmer, Mark Milton, Brian Long, Bart Corsaro, Vahid Farrokhi, Michele Fiscella, Neil Henderson, Vibha Jawa, Jim McNally, Rocio Murphy, Hanspeter Waldner, Tong-Yuan Yang
Publikováno v:
Bioanalysis. 11:2207-2244
The 2019 13th Workshop on Recent Issues in Bioanalysis (WRIB) took place in New Orleans, LA, USA on April 1–5, 2019 with an attendance of over 1000 representatives from pharmaceutical/biopharmaceutical companies, biotechnology companies, contract r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d81a589202e4c0b3c30c4ddc1d93790
https://doi.org/10.4155/bio-2019-0271
https://doi.org/10.4155/bio-2019-0271
Autor:
Bin Ma, Urjana Poreci, Luisette Delva, Fengmei Zhang, Hao Tang, Tonika Bohnert, Patricia Schroeder, Richard Grater, Sudarshan Kapadnis, Kris King, Michael Mingueneau, Marc Hoemberger, Evelyne Polack, Brian T. Hopkins, Prince Robin, Chris Rowbottom, Robert Meissner, Eris Bame, Joseph C Santoro, Paramasivam Murugan, Allie M Roach, Claire M. Metrick, Kevin L. Otipoby, Eric Tien, Josh Johnson, Douglas Donaldson, Joseph P. Lyssikatos, Doug Burdette, Tom Magee, Carrie Boiselle, Chungang Gu, Mukesh Lulla, Bekim Bajrami, Jeremy C. Burns, Cheryl Black, Marx Isaac
Publikováno v:
Journal of medicinal chemistry. 65(2)
Multiple Sclerosis is a chronic autoimmune neurodegenerative disorder of the central nervous system (CNS) that is characterized by inflammation, demyelination, and axonal injury leading to permeant disability. In the early stage of MS, inflammation i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d73da50c6f550d3e41002d416b5cebb6
https://pubmed.ncbi.nlm.nih.gov/34734694
https://pubmed.ncbi.nlm.nih.gov/34734694
Publikováno v:
The AAPS Journal
The objective of this manuscript is to provide the reader with a hypothetical case study to present an immunogenicity risk assessment for a multi-specific therapeutic as part of Investigational New Drug (IND) application. In order to provide context
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19979cc2127e9bd1df61c79306a93f2b
https://doi.org/10.1208/s12248-021-00642-5
https://doi.org/10.1208/s12248-021-00642-5
Autor:
Bin Ma, Claire M. Metrick, Chungang Gu, Marc Hoemberger, Bekim Bajrami, Eris Bame, Jiansheng Huang, Michael Mingueneau, Paramasivam Murugan, Joseph C. Santoro, Hao Tang, Ti Wang, Brian T. Hopkins
Publikováno v:
Bioorganicmedicinal chemistry letters. 60
BTK is a tyrosine kinase playing an important role in B cell and myeloid cell functions through B cell receptor (BCR) signaling and Fc receptor (FcR) signaling. Selective inhibition of BTK has the potential to provide therapeutical benefits to patien
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85bd32b8fdba50b6f9d163e6c24a3190
https://pubmed.ncbi.nlm.nih.gov/35728998
https://pubmed.ncbi.nlm.nih.gov/35728998
Autor:
Bin Ma, Claire M. Metrick, Chungang Gu, Marc Hoemberger, Bekim Bajrami, Eris Bame, Jiansheng Huang, Michael Mingueneau, Paramasivam Murugan, Marta Nevalainen, Joseph C. Santoro, Hao Tang, Ti Wang, Brian T. Hopkins
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 72:128856
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a2269328ef74fb6f1cdf55f7c5dd90de
https://doi.org/10.1016/j.bmcl.2022.128856
https://doi.org/10.1016/j.bmcl.2022.128856
Autor:
Tonika Bohnert, Brian T. Hopkins, Stig Hansen, Laura Silvian, Patrick Cullen, Min Zhong, Stacey A. Heumann, Junfa Fan, Noah Bell, Elisabeth Mertsching, Tracy J. Jenkins, Ella Negrou, Eris Bame, Douglas Marcotte, Kevin L. Otipoby, Michael J. Romanowski, Bob McDowell, Wenjin Yang, Daniel A. Erlanson, Patrick Conlon, Mark T. Cancilla, Minna Bui, Urjana Poreci, Daniel Scott, Tarra Fuchs-Knotts, Jon K. Bowden-Verhoek
Publikováno v:
Bioorganic & Medicinal Chemistry. 27:2905-2913
Since the approval of ibrutinib for the treatment of B-cell malignancies in 2012, numerous clinical trials have been reported using covalent inhibitors to target Bruton's tyrosine kinase (BTK) for oncology indications. However, a formidable challenge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4f47fdcd71f2c89e2f54cba793dfbcb
https://doi.org/10.1016/j.bmc.2019.05.021
https://doi.org/10.1016/j.bmc.2019.05.021
Autor:
Jing Zhu, Xiaomei Peng, Alex Pellerin, Brian T. Hopkins, Dipen Sangurdekar, Michael Mingueneau, Urjana Poreci, Eris Bame, Joseph C Santoro, Prince Robin, Katherine Riester, Mike Palte, Allie M Roach, Klaus Michelsen, Bin Ma, Hao Tang, Million Arefayene, Stephen J Rubino, Devangi Mehta, Fergal Casey, Patrick Cullen, Patrick Trapa, Bekim Bajrami, Thomas M. Carlile, Davide Gianni, Marx Isaac, Douglas Donaldson, Baohong Zhang, Jeremy C. Burns, Param Muragan, Alex Coppell, Shibeshih Belachew, Nathalie Franchimont, Matthew Scaramozza
Publikováno v:
Clinical & Translational Immunology
Clinical & Translational Immunology, Vol 10, Iss 6, Pp n/a-n/a (2021)
Clinical & Translational Immunology, Vol 10, Iss 6, Pp n/a-n/a (2021)
Objectives Bruton's tyrosine kinase (BTK) plays a non‐redundant signaling role downstream of the B‐cell receptor (BCR) in B cells and the receptors for the Fc region of immunoglobulins (FcR) in myeloid cells. Here, we characterise BIIB091, a nove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::188cf6754afaaa237193991f00885497
https://doi.org/10.1002/cti2.1295
https://doi.org/10.1002/cti2.1295