Zobrazeno 1 - 10
of 104
pro vyhledávání: '"Erinna F. Lee"'
Autor:
Rhynelle S. Dmello, Michelle Palmieri, Pathum S. Thilakasiri, Larissa Doughty, Tracy L. Nero, Ashleigh R. Poh, Sarah Q. To, Erinna F. Lee, W. Douglas Fairlie, Lisa Mielke, Michael W. Parker, Ivan K. H. Poon, Eduard Batlle, Matthias Ernst, Ashwini L. Chand
Publikováno v:
Cell Death and Disease, Vol 15, Iss 4, Pp 1-13 (2024)
Abstract Excessive STAT3 signalling via gp130, the shared receptor subunit for IL-6 and IL-11, contributes to disease progression and poor survival outcomes in patients with colorectal cancer. Here, we provide evidence that bazedoxifene inhibits tumo
Externí odkaz:
https://doaj.org/article/edd38efeaa4746be83b35dd07210b0bf
Autor:
Laura J. Jenkins, Ian Y. Luk, Fiona Chionh, Tao Tan, Kristen Needham, Jamieson Ayton, Camilla M. Reehorst, Natalia Vukelic, Oliver M. Sieber, Dmitri Mouradov, Peter Gibbs, David S. Williams, Niall C. Tebbutt, Jayesh Desai, Frédéric Hollande, Amardeep S. Dhillon, Erinna F. Lee, Delphine Merino, W. Douglas Fairlie, John M. Mariadason
Publikováno v:
Cell Death and Disease, Vol 15, Iss 3, Pp 1-9 (2024)
Abstract Metastatic BRAF V600E colorectal cancer (CRC) carries an extremely poor prognosis and is in urgent need of effective new treatments. While the BRAFV600E inhibitor encorafenib in combination with the EGFR inhibitor cetuximab (Enc+Cet) was rec
Externí odkaz:
https://doaj.org/article/6e4f88d9b616433e88bdbae69ee002cc
Autor:
Sharon Tran, Juliani Juliani, Tiffany J. Harris, Marco Evangelista, Julian Ratcliffe, Sarah L. Ellis, David Baloyan, Camilla M. Reehorst, Rebecca Nightingale, Ian Y. Luk, Laura J. Jenkins, Sonia Ghilas, Marina H. Yakou, Chantelle Inguanti, Chad Johnson, Michael Buchert, James C. Lee, Peter De Cruz, Kinga Duszyc, Paul A. Gleeson, Benjamin T. Kile, Lisa A. Mielke, Alpha S. Yap, John M. Mariadason, W. Douglas Fairlie, Erinna F. Lee
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-13 (2024)
Abstract Autophagy-related genes have been closely associated with intestinal homeostasis. BECLIN1 is a component of Class III phosphatidylinositol 3-kinase complexes that orchestrate autophagy initiation and endocytic trafficking. Here we show intes
Externí odkaz:
https://doaj.org/article/fc863b699bb647f5926120d1c9e15000
Autor:
Tiffany J. Harris, Yang Liao, Wei Shi, Marco Evangelista, Bhupinder Pal, Hamsa Puthalakath, Roger Aston, Richard Mollard, John M. Mariadason, Erinna F. Lee, Walter D. Fairlie
Publikováno v:
Cancer Medicine, Vol 12, Iss 12, Pp 13522-13537 (2023)
Abstract Background Monepantel is an anti‐helminthic drug that also has anti‐cancer properties. Despite several studies over the years, the molecular target of monepantel in mammalian cells is still unknown, and its mechanism‐of‐action is not
Externí odkaz:
https://doaj.org/article/4de6c05fb4a64bbe80971501cf5ed780
Autor:
Surein Arulananda, Megan O’Brien, Marco Evangelista, Laura J. Jenkins, Ashleigh R. Poh, Marzena Walkiewicz, Trishe Leong, John M. Mariadason, Jonathan Cebon, Srividya B. Balachander, Justin R. Cidado, Erinna F. Lee, Thomas John, Walter D. Fairlie
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-9 (2021)
Abstract Malignant pleural mesothelioma (MPM) is an aggressive cancer with treatment limited to Cisplatin and Pemetrexed chemotherapy. Recently, we showed that drugs targeting the BCL-2-regulated apoptosis pathway could kill MPM cell lines in vitro,
Externí odkaz:
https://doaj.org/article/ad883c64d8a746e29bfa7c2330196e64
Autor:
Surein Arulananda, Megan O’Brien, Marco Evangelista, Tiffany J. Harris, Nikita S. Steinohrt, Laura J. Jenkins, Marzena Walkiewicz, Robert J. J. O’Donoghue, Ashleigh R. Poh, Bibhusal Thapa, David S. Williams, Trishe Leong, John M. Mariadason, Xia Li, Jonathan Cebon, Erinna F. Lee, Thomas John, W. Douglas Fairlie
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-1 (2021)
Externí odkaz:
https://doaj.org/article/768c48b448e544079fe397dafe8d4bf3
Publikováno v:
Cells, Vol 10, Iss 6, p 1522 (2021)
BECLIN1 is a well-established regulator of autophagy, a process essential for mammalian survival. It functions in conjunction with other proteins to form Class III Phosphoinositide 3-Kinase (PI3K) complexes to generate phosphorylated phosphatidylinos
Externí odkaz:
https://doaj.org/article/856812eba604410fabdd85e29c26f564
Autor:
Walter Douglas Fairlie, Erinna F. Lee
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 6, p 2841 (2021)
B-Cell Lymphoma 2 (BCL-2), c-MYC and related proteins are arguably amongst the most widely studied in all of biology. Every year there are thousands of papers reporting on different aspects of their biochemistry, cellular and physiological mechanisms
Externí odkaz:
https://doaj.org/article/8bc82a76f4754de598a5d0b8de6c35f4
Autor:
Erinna F. Lee, W. Douglas Fairlie
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 9, p 2234 (2019)
Interactions between the pro-survival and pro-apoptotic members of the Bcl-2 family of proteins dictate whether a cell lives or dies. Much of our knowledge of the molecular details of these interactions has come from biochemical and structural studie
Externí odkaz:
https://doaj.org/article/b5442edbfcf64fa4b49d03e6032f9dd3
Autor:
Erinna F. Lee, W. Douglas Fairlie
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 1, Iss 1 (2012)
Externí odkaz:
https://doaj.org/article/1bf5f8981478401abcee4a23918af6ec