Serine 62-Phosphorylated MYC Associates with Nuclear Lamins and Its Regulation by CIP2A Is Essential for Regenerative Proliferation

Autor: Kevin Myant, Xi Qiao, Tuuli Halonen, Christophe Come, Anni Laine, Mahnaz Janghorban, Johanna I. Partanen, John Cassidy, Erinn-Lee Ogg, Patrizia Cammareri, Tiina Laiterä, Juha Okkeri, Juha Klefström, Rosalie C. Sears, Owen J. Sansom, Jukka Westermarck

Publikováno v: Cell Reports, Vol 12, Iss 6, Pp 1019-1031 (2015)

An understanding of the mechanisms determining MYC’s transcriptional and proliferation-promoting activities in vivo could facilitate approaches for MYC targeting. However, post-translational mechanisms that control MYC function in vivo are poorly u

Externí odkaz: https://doaj.org/article/9192a9a0cda04901aa08c766517eccaa

The RAC1 activator Tiam1 regulates centriole duplication through controlling PLK4 levels

Autor: Andrew P. Porter, Gavin R M White, Helen J. Whalley, Erinn-Lee Ogg, Angeliki Malliri

SummaryCentriole duplication is tightly controlled to maintain correct centriole number through the cell cycle. A key component of this control is the regulated degradation of PLK4, the master regulator of centriole duplication. Here we show that the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c424372934b0e441e2332565d698bc6f
https://doi.org/10.1101/2020.05.20.106120

Serine 62-Phosphorylated MYC Associates with Nuclear Lamins and Its Regulation by CIP2A Is Essential for Regenerative Proliferation

Autor: Kevin Myant, Tuuli Halonen, Erinn Lee Ogg, John W. Cassidy, Anni Laine, Tiina Laiterä, Rosalie C. Sears, Mahnaz Janghorban, Jukka Westermarck, Owen J. Sansom, Christophe Côme, Juha Klefström, Johanna I. Partanen, Juha Okkeri, Xi Qiao, Patrizia Cammareri

Publikováno v: Cell Reports, Vol 12, Iss 6, Pp 1019-1031 (2015)
Myant, K, Qiao, X, Halonen, T, Come, C, Laine, A, Janghorban, M, Partanen, J, Cassidy, J, Ogg, E, Cammareri, P, Laiterä, T, Okkeri, J, Klefström, J, Sears, R, Sansom, O & Westermarck, J 2015, ' Serine 62-Phosphorylated MYC Associates with Nuclear Lamins and Its Regulation by CIP2A Is Essential for Regenerative Proliferation ', Cell Reports, vol. 12, no. 6, pp. 1019-1031 . https://doi.org/10.1016/j.celrep.2015.07.003

An understanding of the mechanisms determining MYC's transcriptional and proliferation-promoting activities in vivo could facilitate approaches for MYC targeting. However, post-translational mechanisms that control MYC function in vivo are poorly und

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82131f1b06b1e00aa470a63c57e9ae59
https://pubmed.ncbi.nlm.nih.gov/26235622

The miR-15a-miR-16-1 Locus is Homozygously Deleted in a Subset of Prostate Cancers

Autor: Olli Kallioniemi, Harri Lähdesmäki, Heidi Pukkila, Kati P. Porkka, Erinn Lee Ogg, Tapio Visakorpi, Outi R. Saramäki, Robert L. Vessella, Maija Wolf, G. Jenster, Wytske M. van Weerden

Publikováno v: Genes Chromosomes & Cancer, 50(7), 499-509. Wiley-Liss Inc.

MicroRNAs (miRNAs) are small, non-coding RNAs that negatively regulate the expression of protein coding genes. In this study, we screened highly informative prostate cancer cell lines and xenografts (n = 42) for miRNA gene copy number and expression

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad553829119686c3581ff7d6ce3d2100