Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Erine H Budi"'
Dual inhibition of αvβ6 and αvβ1 reduces fibrogenesis in lung tissue explants from patients with IPF
Autor:
Martin L. Decaris, Johanna R. Schaub, Chun Chen, Jacob Cha, Gail G. Lee, Megi Rexhepaj, Steve S. Ho, Vikram Rao, Megan M. Marlow, Prerna Kotak, Erine H. Budi, Lisa Hooi, Jianfeng Wu, Marina Fridlib, Shamra P. Martin, Shaoyi Huang, Ming Chen, Manuel Muñoz, Timothy F. Hom, Paul J. Wolters, Tushar J. Desai, Fernando Rock, Katerina Leftheris, David J. Morgans, Eve-Irene Lepist, Patrick Andre, Eric A. Lefebvre, Scott M. Turner
Publikováno v:
Respiratory Research, Vol 22, Iss 1, Pp 1-14 (2021)
Abstract Rationale αv integrins, key regulators of transforming growth factor-β activation and fibrogenesis in in vivo models of pulmonary fibrosis, are expressed on abnormal epithelial cells (αvβ6) and fibroblasts (αvβ1) in fibrotic lungs. Obj
Externí odkaz:
https://doaj.org/article/f75a5266ef724db48db905d69406f78e
Publikováno v:
iScience, Vol 11, Iss , Pp 474-491 (2019)
Summary: Angiogenesis, the development of new blood vessels, is a key process in disease. We reported that insulin promotes translocation of transforming growth factor β (TGF-β) receptors to the plasma membrane of epithelial and fibroblast cells, t
Externí odkaz:
https://doaj.org/article/9e41c6dd15564952b7f29e1ffbb0bd14
Autor:
Baby Periyanayaki Muthusamy, Erine H Budi, Yoko Katsuno, Matthew K Lee, Susan M Smith, Amer M Mirza, Rosemary J Akhurst, Rik Derynck
Publikováno v:
PLoS Biology, Vol 13, Iss 12, p e1002325 (2015)
Epithelial-mesenchymal transition (EMT) is a normal cell differentiation event during development and contributes pathologically to carcinoma and fibrosis progression. EMT often associates with increased transforming growth factor-β (TGF-β) signali
Externí odkaz:
https://doaj.org/article/d85a77fa54ba4e958968dab744966a4b
Dual inhibition of αvβ6 and αvβ1 reduces fibrogenesis in lung tissue explants from patients with IPF
Autor:
Patrick Andre, Martin Decaris, Chun Chen, Munoz Manuel, Hom Timothy, Scott M. Turner, Ming Chen, Tushar J. Desai, Megan M. Marlow, Cha Jacob, Eric Lefebvre, Steve S. Ho, Paul J. Wolters, Shaoyi Huang, Eve-Irene Lepist, Katerina Leftheris, David J Morgans, Lisa Hooi, Johanna R. Schaub, Vikram R. Rao, Jianfeng Wu, Marina Fridlib, Fernando Rock, Megi Rexhepaj, Erine H. Budi, Prerna Kotak, Gail Lee, Shamra Martin
Publikováno v:
Respiratory research, vol 22, iss 1
Respiratory Research, Vol 22, Iss 1, Pp 1-14 (2021)
Respiratory Research, Vol 22, Iss 1, Pp 1-14 (2021)
Rationale αv integrins, key regulators of transforming growth factor-β activation and fibrogenesis in in vivo models of pulmonary fibrosis, are expressed on abnormal epithelial cells (αvβ6) and fibroblasts (αvβ1) in fibrotic lungs. Objectives W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8943da51a8a3553a1e3711bc9a9ed07
https://escholarship.org/uc/item/5q12m0vq
https://escholarship.org/uc/item/5q12m0vq
Publikováno v:
The Journal of pathologyReferences. 254(4)
Many chronic diseases are marked by fibrosis, which is defined by an abundance of activated fibroblasts and excessive deposition of extracellular matrix, resulting in loss of normal function of the affected organs. The initiation and progression of f
Publikováno v:
iScience
iScience, Vol 11, Iss, Pp 474-491 (2019)
iScience, Vol 11, Iss, Pp 474-491 (2019)
Summary Angiogenesis, the development of new blood vessels, is a key process in disease. We reported that insulin promotes translocation of transforming growth factor β (TGF-β) receptors to the plasma membrane of epithelial and fibroblast cells, th
Publikováno v:
Scientific reports, vol 9, iss 1
Scientific Reports, Vol 9, Iss 1, Pp 1-16 (2019)
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-16 (2019)
Scientific Reports
Insulin signaling governs many processes including glucose homeostasis and metabolism, and is therapeutically used to treat hyperglycemia in diabetes. We demonstrated that insulin-induced Akt activation enhances the sensitivity to TGF-β by directing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a17373be297490dea4a0149fb225dfc
https://escholarship.org/uc/item/1jp5x4gj
https://escholarship.org/uc/item/1jp5x4gj
Publikováno v:
PLoS Genetics, Vol 7, Iss 5, p e1002044 (2011)
The pigment cells of vertebrates serve a variety of functions and generate a stunning variety of patterns. These cells are also implicated in human pathologies including melanoma. Whereas the events of pigment cell development have been studied exten
Externí odkaz:
https://doaj.org/article/0160c7fcf41d489696215f9b2de60851
Autor:
Keith A Hultman, Erine H Budi, Daniel C Teasley, Andrew Y Gottlieb, David M Parichy, Stephen L Johnson
Publikováno v:
PLoS Genetics, Vol 5, Iss 7, p e1000544 (2009)
Adult stem cells are responsible for maintaining and repairing tissues during the life of an organism. Tissue repair in humans, however, is limited compared to the regenerative capabilities of other vertebrates, such as the zebrafish (Danio rerio). A
Externí odkaz:
https://doaj.org/article/7aa332eac91340b3a76f1f3d1fa05901
Publikováno v:
Trends in Cell Biology. 27:658-672
Transforming growth factor (TGF)-β family proteins control cell physiology, proliferation, and growth, and direct cell differentiation, thus playing key roles in normal development and disease. The mechanisms of how TGF-β family ligands interact wi