Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Erin Waters"'
Autor:
Maximillian A. Robinson, Alan Kennedy, Carolina T. Orozco, Hung-Chang Chen, Erin Waters, Dalisay Giovacchini, Kay Yeung, Lily Filer, Claudia Hinze, Christopher Lloyd, Simon J. Dovedi, David M. Sansom
Publikováno v:
Cell Reports, Vol 43, Iss 9, Pp 114768- (2024)
Summary: The CTLA-4 and PD-1 checkpoints control immune responses and are key targets in immunotherapy. Both pathways are connected via a cis interaction between CD80 and PD-L1, the ligands for CTLA-4 and PD-1, respectively. This cis interaction prev
Externí odkaz:
https://doaj.org/article/bd659b5fd6cd460e8b103ac0c7d928f7
Avoided Hospitalization Criteria: Validating the Impact of a Community-Based Palliative Care Program
Autor:
Gobi Paramanandam, Barbara E. Volk-Craft, Rachel Mayer Brueckner, Theresa M. O'Sullivan, Erin Waters
Publikováno v:
Palliative Medicine Reports, Vol 1, Iss 1, Pp 246-250 (2020)
Objective: This report describes the experiences of a community-based palliative care (CBPC) program's efforts to understand the patterns of hospital utilization, specifically utilization reduction experienced by admitted patients. Efforts to quantif
Externí odkaz:
https://doaj.org/article/f602a641553b4f509d4b1f270b57bf9f
Autor:
Neil Halliday, Cayman Williams, Alan Kennedy, Erin Waters, Anne M. Pesenacker, Blagoje Soskic, Claudia Hinze, Tie Zheng Hou, Behzad Rowshanravan, Daniel Janman, Lucy S. K. Walker, David M. Sansom
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
CD80 and CD86 are expressed on antigen presenting cells and are required to engage their shared receptor, CD28, for the costimulation of CD4 T cells. It is unclear why two stimulatory ligands with overlapping roles have evolved. CD80 and CD86 also bi
Externí odkaz:
https://doaj.org/article/4bb9b3851d544090be42099ef370e403
Publikováno v:
Medical Education. 56:915-921
There is widespread agreement about the importance of direct observation of trainee practice by clinical supervisors. Less is known about observation by observers external to the supervisory team. We explored the educational affordances of external o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b60ba471788d943802510eb76c537e93
https://doi.org/10.1111/medu.14841
https://doi.org/10.1111/medu.14841
Autor:
Alan Kennedy, Maximillian A Robinson, Claudia Hinze, Erin Waters, Cayman Williams, Neil Halliday, Simon Dovedi, David M Sansom
Publikováno v:
The EMBO Journal. 42
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e1a1b0dbbe1a7f6e1c14899ae079b9eb
https://doi.org/10.15252/embj.2022111556
https://doi.org/10.15252/embj.2022111556
Autor:
Thomas Andrew Fox, Benjamin Christopher Houghton, Lina Petersone, Erin Waters, Natalie Mona Edner, Alex McKenna, Olivier Preham, Claudia Hinze, Cayman Williams, Adriana Silva de Albuquerque, Alan Kennedy, Anne Maria Pesenacker, Pietro Genovese, Lucy Sarah Kate Walker, Siobhan Oisin Burns, David Michael Sansom, Claire Booth, Emma Catherine Morris
Publikováno v:
Science translational medicine. 14(668)
Heterozygous mutations inCTLA-4result in an inborn error of immunity with an autoimmune and frequently severe clinical phenotype. Autologous T cell gene therapy may offer a cure without the immunological complications of allogeneic hematopoietic stem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e50118c9853b389356867d3f4ad76e55
https://pubmed.ncbi.nlm.nih.gov/36288278
https://pubmed.ncbi.nlm.nih.gov/36288278
Publikováno v:
Methods in Molecular Biology ISBN: 9781071626467
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fcc18e75b6fe26663e3a561250aba9f2
https://doi.org/10.1007/978-1-0716-2647-4_12
https://doi.org/10.1007/978-1-0716-2647-4_12
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2559
Regulatory T Cells (Tregs) constitutively express the inhibitory receptor CTLA-4, which is fundamental to their role in immune suppression. Mechanistically, CTLA-4 on Tregs can attenuate T cell activation by physically removing and internalizing cost
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2b8cde1025e3831cd274ab3c1cd640b6
https://pubmed.ncbi.nlm.nih.gov/36180633
https://pubmed.ncbi.nlm.nih.gov/36180633
Autor:
Cayman Williams, Alan Kennedy, Shane Minogue, Neil Halliday, Erin Waters, David M. Sansom, Tie Zheng Hou, Behzad Rowshanravan, Daniel Janman, Claudia Hinze, Omar S. Qureshi
Publikováno v:
Immunology
CTLA‐4 is an essential regulator of T‐cell immune responses whose intracellular trafficking is a hallmark of its expression. Defects in CTLA‐4 trafficking due to LRBA deficiency cause profound autoimmunity in humans. CTLA‐4 rapidly internaliz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5cddda139f956ca1c0f3dfc3613555c
http://europepmc.org/articles/PMC8358724
http://europepmc.org/articles/PMC8358724
Autor:
Alan Kennedy, Max Robinson, Claudia Hinze, Erin Waters, Cayman Williams, Neil Halliday, Simon Dovedi, David M Sansom
CTLA-4 and PD-1 are key immune checkpoints that are targeted in the treatment of cancer. Recently it has emerged that there is a physical interaction between the ligands of these pathways (CD80 and PD-L1), which can prevent PD-L1 inhibitory functions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c7af629f1a7bdf992d014e1ff2a414d
https://doi.org/10.1101/2022.03.28.486104
https://doi.org/10.1101/2022.03.28.486104