Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Erin S. Palmer"'
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Cyclic lactam hybrid α-MSH/Agouti-related protein (AGRP) analogues with nanomolar range binding affinities at the human melanocortin receptors
Autor: Victor J. Hruby, Bahar Tan, Minying Cai, Alexander V. Mayorov, James P. Cain, Erin S. Palmer, Matthew M. Dedek, Dev Trivedi, Dustin K. Tanaka
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 21:3099-3102
A novel hybrid melanocortin pharmacophore was designed based on the topographical similarities between the pharmacophores of Agouti related protein (AGRP) an endogenous melanocortin antagonist, and α-melanocyte-stimulating hormone (α-MSH), an endog
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23bc881439fa48b9cbe5ea551c4310cc
https://doi.org/10.1016/j.bmcl.2011.03.019
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Solid-phase peptide head-to-side chain cyclodimerization: Discovery of C2-symmetric cyclic lactam hybrid α-melanocyte-stimulating hormone (MSH)/agouti-signaling protein (ASIP) analogues with potent activities at the human melanocortin receptors
Autor: Zhihua Liu, Minying Cai, Victor J. Hruby, Erin S. Palmer, Dev Trivedi, Alexander V. Mayorov, James P. Cain, Josef Vagner
Publikováno v: Peptides. 31:1894-1905
A novel hybrid melanocortin pharmacophore was designed based on the pharmacophores of the Agouti signaling protein (ASIP), an endogenous melanocortin antagonist, and α-melanocyte-stimulating hormone (α-MSH), an endogenous melanocortin agonist. The
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::512acab156c72c0d098f372d3e05add8
https://doi.org/10.1016/j.peptides.2010.06.026
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4
Multiple N-Methylation of MT-II Backbone Amide Bonds Leads to Melanocortin Receptor Subtype hMC1R Selectivity: Pharmacological and Conformational Studies
Autor: Johannes G. Beck, Lucas Doedens, Horst Kessler, Florian Opperer, Matt Dedek, Victor J. Hruby, Erin S. Palmer, Minying Cai
Publikováno v: Journal of the American Chemical Society. 132:8115-8128
Multiple N-methylation is a novel technology to improve bioavailability of peptides and increase receptor subtype selectivity. This technique has been applied here to the superpotent but nonselective cyclic peptide MT-II. A library of all possible 31
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::468edb7745ff65c0ab7e63036bef7394
https://doi.org/10.1021/ja101428m
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5
Structure–Activity Relationships of Cyclic Lactam Analogues of α-Melanocyte-Stimulating Hormone (α-MSH) Targeting the Human Melanocortin-3 Receptor
Autor: Matthew M. Dedek, Minying Cai, Josef Vagner, Erin S. Palmer, Bahar Tan, April R. Van Scoy, James P. Cain, Victor J. Hruby, Alexander V. Mayorov, Dev Trivedi
Publikováno v: Journal of Medicinal Chemistry. 51:187-195
A variety of dicarboxylic acid linkers introduced between the alpha-amino group of Pro(6) and the -amino group of Lys(10) of the cyclic lactam alpha-melanocyte-stimulating hormone (alpha-MSH)-derived Pro(6)-D-Phe(7)/D-Nal(2')(7)-Arg(8)-Trp(9)-Lys(10)
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d6fcea9b8832c048124f399df5de4aa
https://doi.org/10.1021/jm070461w
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6
Peptide and Non-Peptide Mimetics Utilize Different Pathways for Signal Transduction
Autor: Yingqui Yang, George Tsaprailis, Hongchang Qu, Minying Cai, Alexander V. Mayorov, Erin S. Palmer, Matt Dedek, Dev Trivedi, Victor J. Hruby
Publikováno v: Advances in Experimental Medicine and Biology ISBN: 9780387736563
Introduction Despite the central importance of peptides as drugs such as insulin, oxytocin, calcitonin, ace inhibitors, etc., there has been a prejudice against developing peptide drugs. Instead large efforts are made to develop non-peptide small mol
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::df65f1120a589df8f623769b094ec466
https://doi.org/10.1007/978-0-387-73657-0_137
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8
Novel selective human melanocortin-3 receptor ligands: use of the 4-amino-1,2,4,5-tetrahydro-2-benzazepin-3-one (Aba) scaffold
Autor: Dagmara Tymecka, Minying Cai, Alexander V. Mayorov, Aleksandra Misicka, Steven Ballet, Dirk Tourwé, Karolien Van Rompaey, Erin S. Palmer, Kevin B. Chandler, Victor J. Hruby
Publikováno v: Bioorganicmedicinal chemistry letters. 17(9)
In search of new selective antagonists and/or agonists for the human melanocortin receptor subtypes hMC1R to hMC5R to elucidate the specific biological roles of each GPCR, we modified the structures of the superagonist MT-II (Ac-Nle-c[Asp-His-D-Phe-A
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::631bcf1b6ffafafec792cf95ef5fc833
https://pubmed.ncbi.nlm.nih.gov/17314042
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