Blood Levels of Angiotensinogen and Hypertension in the Multi-Ethnic Study of Atherosclerosis (MESA)

Autor: Patrick J. Trainor, Michela Brambatti, Samantha M. Carlisle, Adam E. Mullick, Sanjiv J. Shah, Tanvir Kahlon, Diana Otero Mostacero, Hossein Mousavi, Erin S. Morgan, Yvonne Tami, Erin D. Michos, Pamela Ouyang, Sotirios Tsimikas, Andrew P. DeFilippis

Publikováno v: Journal of the American College of Cardiology. 81:1248-1259

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3391773905c5f6f95ff9b1b40025516c
https://doi.org/10.1016/j.jacc.2023.01.033

Antisense Inhibition of Angiotensinogen With IONIS-AGT-L

Autor: Yvonne Tami, Erin S. Morgan, George L. Bakris, Richard S. Geary, Adam E. Mullick, Kuolung Hu, Michela Brambatti, Sotirios Tsimikas

Publikováno v: JACC: Basic to Translational Science

Visual Abstract
Highlights • Targeting AGT is a novel approach to inhibit the RAAS pathway. • AGT is primarily synthesized in the liver. • IONIS-AGT-LRx is an ASO directed to hepatocyte-derived AGT. • In 2 phase 2 trials as monotherapy a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14e616d76b659e1de4ea238019d64e1e
https://pubmed.ncbi.nlm.nih.gov/34040182

Population pharmacokinetics and pharmacodynamics of IONIS-GCGRRx, an antisense oligonucleotide for type 2 diabetes mellitus: a red blood cell lifespan model

Autor: Yanfeng Wang, Scott P. Henry, Sanjay Bhanot, Erin S. Morgan, Kenneth T. Luu, Lynnetta Watts, Richard S. Geary, Claudette Bethune, Anne Smith

Publikováno v: Journal of Pharmacokinetics and Pharmacodynamics. 44:179-191

IONIS-GCGRRx (ISIS 449884) is an antisense oligonucleotide inhibitor of the glucagon receptor (GCGR). The objective of this study was to evaluate the pharmacokinetics (PK) and pharmacodynamics (PD) of IONIS-GCGRRx via population-based modeling. The o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7636f110567fa6059b9e232b4ca520df
https://doi.org/10.1007/s10928-017-9505-5

Antisense Inhibition of Protein Tyrosine Phosphatase 1B With IONIS-PTP-1B

Autor: Andres, Digenio, Nguyen C, Pham, Lynnetta M, Watts, Erin S, Morgan, Shiangtung W, Jung, Brenda F, Baker, Richard S, Geary, Sanjay, Bhanot

Publikováno v: Diabetes care. 41(4)

To evaluate safety and efficacy of IONIS-PTP-1BIn this phase II, double-blind, randomized, placebo-controlled, multicenter trial, overweight and obese patients (BMI ≥27 kg/mMean baseline HbACompared with placebo, IONIS-PTP-1B

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2abe9a51cd98dea129a9af2ce74ace30
https://pubmed.ncbi.nlm.nih.gov/29439147

Characterization of a standardized glucagon challenge test as a pharmacodynamic tool in pharmacological research

Autor: Bart F. Geerts, M. G. J. van Dongen, M. L. de Kam, Sanjay Bhanot, Jacobus Burggraaf, Erin S. Morgan, Johannes A. Romijn, Adam F. Cohen, Matthijs Moerland

Publikováno v: Hormone and metabolic research. Hormon-und Stoffwechselforschung. Hormones et metabolisme, 46(4), 269-273. Georg Thieme Verlag
Hormone and Metabolic Research, 46(4), 269-273

aim of this study was to characterize a glucagon challenge test as a tool in diabetes research by assessing the inter- and intra-indi- vidual variability, and investigating the activity of the autonomic nervous system (ANS) during the challenge, as t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::277f47a3bff6e3643e60a6948ccb9d66
https://pure.amc.nl/en/publications/characterization-of-a-standardized-glucagon-challenge-test-as-a-pharmacodynamic-tool-in-pharmacological-research(c385cefd-ff84-472c-b788-fe2890ff66d8).html