Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Erin Riegler"'
Autor:
Scott Jacobson, Dennis X. Hu, Cesar Meleza, Mikhail Zibinsky, Ashkaan Younai, Erin Riegler, Omar Robles, Jenny McKinnell, Emily Karbarz, Paul D. Kassner, Lisa A. Marshall, Maureen Kay Reilly, David Chian, Gene Cutler, David J. Wustrow, Dirk G. Brockstedt, Hunter P. Shunatona, Raymond Diokno, Angela Wadsworth, John M. Ketcham, Oezcan Talay, Jeffrey J. Jackson
Publikováno v:
Journal of Medicinal Chemistry. 63:8584-8607
The C-C chemokine receptor 4 (CCR4) is broadly expressed on regulatory T cells (Treg) as well as other circulating and tissue-resident T cells. Treg can be recruited to the tumor microenvironment (TME) through the C-C chemokines CCL17 and CCL22. Treg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ff8f25af0448a07583421b7d8d0bfa7
https://doi.org/10.1021/acs.jmedchem.0c00988
https://doi.org/10.1021/acs.jmedchem.0c00988
Autor:
Tod Steinfeld, Timothy Park, Paul S. Humphries, Kerryn McCluskie, Travis Renner, Zhi-Liang Wei, John F. Kincaid, Erik Willis, Ross Bersot, Erin Riegler, Eric Mabery, Eric Douglas Turtle
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:293-297
A series of novel carbazole-containing amides and ureas were synthesized. A structure-activity relationship study of these compounds led to the identification of potent cryptochrome modulators. Based on the desired pharmacokinetic/pharmacodynamic par
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3d5060efe58f3dcac998fab63313eb6
https://doi.org/10.1016/j.bmcl.2017.12.051
https://doi.org/10.1016/j.bmcl.2017.12.051
Autor:
Kerryn McCluskie, Zhi-Liang Wei, Tod Steinfeld, Eric Mabery, Erin Riegler, John F. Kincaid, Ross Bersot, Paul S. Humphries, Erik Willis, Timothy Park, Travis Renner, Eric Douglas Turtle
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:757-760
A series of novel carbazole-containing sulfonamides and sulfamides were synthesized. A structure-activity relationship study of these compounds led to the identification of potent cryptochrome modulators. Based on the results of efficacy studies in d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a17f7c19913f68fff29b7d4dceaa546
https://doi.org/10.1016/j.bmcl.2015.12.102
https://doi.org/10.1016/j.bmcl.2015.12.102
Autor:
Lisa Seitz, Omar Robles, Abood Okal, Erin Riegler, Emily Karbaz, Scott Jacobson, Jenny McKinnell, Angela Wadsworth, Oezcan Talay, Paul D. Kassner, Lisa A. Marshall, David Chian, David J. Wustrow, Maureen Kay Reilly, Mikhail Zibisky, Cesar Meleza, Jordan S. Fridman
Publikováno v:
Cancer Research. 77:4600-4600
Naturally suppressive CD4+ Foxp3+ Treg are essential for immune tolerance. Although Treg-mediated suppression of effector cells is important to control inflammation and prevent autoimmune diseases, the presence of Treg in the tumor microenvironment (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a3b87bf475ea463f95dd6cca5fc91857
https://doi.org/10.1158/1538-7445.am2017-4600
https://doi.org/10.1158/1538-7445.am2017-4600