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pro vyhledávání: '"Erin R. Yarde"'
Autor:
Erin R. Yarde, Michael Naughton, Cynthia X. Ma, Paula M. Fracasso, Philip S. Bernard, Gina R. Petroni, Shi Rong Cai, Timothy J. Pluard, Joel Picus, Matthew J. Ellis, Jerry S. Reed, Mark A. Watson, Laurence A. Doyle, Janet Dancey, Allison N. Creekmore, Tibu Mwandoro, Helen Piwnica-Worms, Christine E. Ryan, A. Craig Lockhart, Zhanfang Guo, Christiana Brenin, Mark T. W. Ebbert
Publikováno v:
Breast Cancer Research and Treatment
Mutations in TP53 lead to a defective G1 checkpoint and the dependence on checkpoint kinase 1 (Chk1) for G2 or S phase arrest in response to DNA damage. In preclinical studies, Chk1 inhibition resulted in enhanced cytotoxicity of several chemotherape