Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Erin R Greiner"'
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e105433 (2014)
Amyloid fibrils are associated with many maladies, including Alzheimer's disease (AD). The isolation of amyloids from natural materials is very challenging because the extreme structural stability of amyloid fibrils makes it difficult to apply conven
Externí odkaz:
https://doaj.org/article/bb53c044be03432aa4bd8b7c196be5ef
Autor:
Nirvan Rouzbeh, Veena Prahlad, Andrew Dillin, Johan Paulsson, Miguel Alves-Ferreira, Carlos A. Aguirre, Kayalvizhi Madhivanan, Erin R. Greiner, David Soriano-Castell, Justin Chapman, Carolina Lemos, Felicia K. Ooi, Sandra E. Encalada, Jeffery W. Kelly, Xin Jiang
Cell-autonomous and cell-nonautonomous mechanisms of neurodegeneration appear to occur in the proteinopathies, including Alzheimer’s and Parkinson’s diseases. However, how neuronal toxicity is generated from misfolding-prone proteins secreted by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c28520a3fb694bc2afade8718726fc9
https://europepmc.org/articles/PMC6099907/
https://europepmc.org/articles/PMC6099907/
Autor:
Fuying Gao, Chang Sin Park, C.Y. Daniel Lee, Erin R. Greiner, Richard Zhang, Istvan Mody, Jeffrey P. Cantle, Xiaofeng Gu, X. William Yang, Marc I. Diamond, Giovanni Coppola, Zhiqiang Zhang, Albert M.I. Barth, Susana Sandoval-Miller
Publikováno v:
Neuron
Neuron, vol 85, iss 4
Neuron, vol 85, iss 4
SUMMARY The nucleus is a critical subcellular compartment for the pathogenesis of polyglutamine disorders, including Huntington’s disease (HD). Recent studies suggest the first 17-amino-acid domain (N17) of mutant Huntingtin (mHTT) mediates its nuc
Autor:
Stephen Connelly, Louis Noodleman, K. Barry Sharpless, Joseph C. Genereux, Nadine C. Bradbury, Jiajia Dong, Sandra E. Encalada, R. Luke Wiseman, Yu Liu, Jeffery W. Kelly, Aleksandra Baranczak, Wen Ge Han Du, Yvonne S. Eisele, Ian A. Wilson, Erin R. Greiner
Fluorogenic probes, due to their often greater spatial and temporal sensitivity in comparison to permanently fluorescent small molecules, represent powerful tools to study protein localization and function in the context of living systems. Herein, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c18911e450469a6c3efdd50d88117ef2
https://europepmc.org/articles/PMC4472559/
https://europepmc.org/articles/PMC4472559/
Autor:
Juan Botas, Ismael Al-Ramahi, David F. Fischer, Richard L.M. Faull, Erin R. Greiner, Alexander P. Osmand, Juan J. Marugan, Clive N. Svendsen, Karla El-Zein, Jingbo Xiao, Nick van den Berg, Seung Kwak, Nan Wang, Ignacio Munoz-Sanjuan, Ethan Signer, Harry V. Vinters, Remko de Pril, Sipke Dijkstra, Virginia B. Mattis, Silvina A. Fratantoni, Xiao-Hong Lu, X. William Yang, Henry J. Waldvogel
Publikováno v:
Science Translational Medicine. 6
Age-related neurodegenerative disorders including Alzheimer's disease and Huntington's disease (HD) consistently show elevated DNA damage, but the relevant molecular pathways in disease pathogenesis remain unclear. One attractive gene is that encodin
Autor:
Erin R. Greiner, X. William Yang
Publikováno v:
Nature Chemical Biology. 7:412-414
Phosphomimetic mutations at huntingtin (Htt) Ser13 and Ser16 within the conserved N-terminal 17-amino-acid domain profoundly suppresses its toxicity in cell and mouse models of Huntington's disease. New research reveals that cell stress acts as a sti
Autor:
Michelle Gray, Carlos Cepeda, Dyna I. Shirasaki, Erin R. Greiner, Jeffrey P. Cantle, Xiao-Hong Lu, Sandra M. Holley, Xiaofeng Gu, Hong-Wei Dong, X. William Yang, Nan Wang, Michael Levine, Yuqing Li
Publikováno v:
Nature medicine. 20(5)
Huntington's disease (HD) is a fatal dominantly inherited neurodegenerative disorder caused by a CAG repeat expansion leading to an elongated polyglutamine stretch in huntingtin. Mutant huntingtin (mHTT) is ubiquitously expressed in all cells but eli
Autor:
Bryce L. Sopher, Xiaofeng Gu, Albert R. La Spada, Erin R. Greiner, Yi E. Sun, Russell L. Margolis, Nan Wang, Yin Cheng, Jing Zhao, X. William Yang, Chang Sin Park, Dobrila D. Rudnicki, Brian Wilburn, Alexander P. Osmand, Tara M. Weitz
Publikováno v:
Neuron. 70(3)
SummaryHuntington's disease-like-2 (HDL2) is a phenocopy of Huntington's disease caused by CTG/CAG repeat expansion at the Junctophilin-3 (JPH3) locus. The mechanisms underlying HDL2 pathogenesis remain unclear. Here we developed a BAC transgenic mou
Autor:
Ravindra Kodali, Steven Finkbeiner, Rakesh Mishra, Joan S. Steffan, Leslie M. Thompson, Xiaofeng Gu, Ronald Wetzel, X. William Yang, Erin R. Greiner, Alexander P. Osmand
Summary The N-terminal 17 amino acids of huntingtin (NT17) can be phosphorylated on serines 13 and 16; however, the significance of these modifications in Huntington's disease pathogenesis remains unknown. In this study, we developed BAC transgenic m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::909fada83048a14983995702714eb2d6
https://europepmc.org/articles/PMC2807408/
https://europepmc.org/articles/PMC2807408/