Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Erin Purcell Estabrook"'
Autor:
Yuanjing Liu, Amy Andreucci, Naoki Iwamoto, Yuan Yin, Hailin Yang, Fangjun Liu, Alexey Bulychev, Xiao Shelley Hu, Xuena Lin, Sarah Lamore, Saurabh Patil, Susovan Mohapatra, Erin Purcell-Estabrook, Kristin Taborn, Elena Dale, Chandra Vargeese
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 28, Iss , Pp 558-570 (2022)
A large hexanucleotide (G4C2) repeat expansion in the first intronic region of C9orf72 is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Several mechanisms have been proposed to explain how the
Externí odkaz:
https://doaj.org/article/abb85617456d47dc9e93f622cb10832e
Autor:
Wei Liu, Naoki Iwamoto, Subramanian Marappan, Khoa Luu, Snehlata Tripathi, Erin Purcell-Estabrook, Juili Dilip Shelke, Himali Shah, Anthony Lamattina, Qianli Pan, Brett Schrand, Frank Favaloro, Mugdha Bedekar, Arindom Chatterjee, Jigar Desai, Tomomi Kawamoto, Genliang Lu, Jake Metterville, Milinda Samaraweera, Priyanka Shiva Prakasha, Hailin Yang, Yuan Yin, Hui Yu, Paloma H Giangrande, Michael Byrne, Pachamuthu Kandasamy, Chandra Vargeese
Publikováno v:
Nucleic Acids Research. 51:4126-4147
Herein, we report the systematic investigation of stereopure phosphorothioate (PS) and phosphoryl guanidine (PN) linkages on siRNA-mediated silencing. The incorporation of appropriately positioned and configured stereopure PS and PN linkages to N-ace
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f52fce2dc6c2c20d3fb621264918bd6b
https://doi.org/10.1093/nar/gkad268
https://doi.org/10.1093/nar/gkad268
Impact of guanidine-containing backbone linkages on stereopure antisense oligonucleotides in the CNS
Autor:
Pachamuthu Kandasamy, Yuanjing Liu, Vincent Aduda, Sandheep Akare, Rowshon Alam, Amy Andreucci, David Boulay, Keith Bowman, Michael Byrne, Megan Cannon, Onanong Chivatakarn, Juili Dilip Shelke, Naoki Iwamoto, Tomomi Kawamoto, Jayakanthan Kumarasamy, Sarah Lamore, Muriel Lemaitre, Xuena Lin, Kenneth Longo, Richard Looby, Subramanian Marappan, Jake Metterville, Susovan Mohapatra, Bridget Newman, Ik-Hyeon Paik, Saurabh Patil, Erin Purcell-Estabrook, Mamoru Shimizu, Pochi Shum, Stephany Standley, Kris Taborn, Snehlata Tripathi, Hailin Yang, Yuan Yin, Xiansi Zhao, Elena Dale, Chandra Vargeese
Publikováno v:
Nucleic Acids Research. 50:5401-5423
Attaining sufficient tissue exposure at the site of action to achieve the desired pharmacodynamic effect on a target is an important determinant for any drug discovery program, and this can be particularly challenging for oligonucleotides in deep tis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5bd2c8b0ca0bc373823740210c986ec
https://doi.org/10.1093/nar/gkac037
https://doi.org/10.1093/nar/gkac037
Autor:
Pachamuthu Kandasamy, Graham McClorey, Mamoru Shimizu, Nayantara Kothari, Rowshon Alam, Naoki Iwamoto, Jayakanthan Kumarasamy, Gopal R Bommineni, Adam Bezigian, Onanong Chivatakarn, David C D Butler, Michael Byrne, Katarzyna Chwalenia, Kay E Davies, Jigar Desai, Juili Dilip Shelke, Ann F Durbin, Ruth Ellerington, Ben Edwards, Jack Godfrey, Andrew Hoss, Fangjun Liu, Kenneth Longo, Genliang Lu, Subramanian Marappan, Jacopo Oieni, Ik-Hyeon Paik, Erin Purcell Estabrook, Chikdu Shivalila, Maeve Tischbein, Tomomi Kawamoto, Carlo Rinaldi, Joana Rajão-Saraiva, Snehlata Tripathi, Hailin Yang, Yuan Yin, Xiansi Zhao, Cong Zhou, Jason Zhang, Luciano Apponi, Matthew J A Wood, Chandra Vargeese
Publikováno v:
Nucleic acids research. 50(10)
Although recent regulatory approval of splice-switching oligonucleotides (SSOs) for the treatment of neuromuscular disease such as Duchenne muscular dystrophy has been an advance for the splice-switching field, current SSO chemistries have shown limi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4563bb9a20823ec7e04b7dd2e362f73
https://pubmed.ncbi.nlm.nih.gov/35061895
https://pubmed.ncbi.nlm.nih.gov/35061895
Autor:
Yuanjing, Liu, Amy, Andreucci, Naoki, Iwamoto, Yuan, Yin, Hailin, Yang, Fangjun, Liu, Alexey, Bulychev, Xiao Shelley, Hu, Xuena, Lin, Sarah, Lamore, Saurabh, Patil, Susovan, Mohapatra, Erin, Purcell-Estabrook, Kristin, Taborn, Elena, Dale, Chandra, Vargeese
Publikováno v:
Molecular therapy. Nucleic acids. 28
A large hexanucleotide (G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d025dde90c1ac7eac62c6d4b93c520b9
https://pubmed.ncbi.nlm.nih.gov/35592494
https://pubmed.ncbi.nlm.nih.gov/35592494
Autor:
Lee-So Maeng, Stephanie D. Lee, Krisztina Fischer, Lori Foley, Wonhye Lee, Seung-Schik Yoo, Hyung-Min Kim, Michael Y. Park, Erin Purcell-Estabrook
Publikováno v:
Ultrasound in Medicine & Biology. 42:459-470
Non-invasive brain stimulation using focused ultrasound has largely been carried out in small animals. In the present study, we applied stimulatory focused ultrasound transcranially to the primary sensorimotor (SM1) and visual (V1) brain areas in she
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa8c828184bd359c4f9faa5a848ee673
https://doi.org/10.1016/j.ultrasmedbio.2015.10.001
https://doi.org/10.1016/j.ultrasmedbio.2015.10.001
Autor:
Wonhye Lee, Erin Purcell-Estabrook, Michael Y. Park, Stephanie D. Lee, Lori Foley, Seung-Schik Yoo, Hyung-Min Kim
Publikováno v:
BMC Veterinary Research
Background An ovine model can cast great insight in translational neuroscientific research due to its large brain volume and distinct regional neuroanatomical structures. The present study examined the applicability of brain functional magnetic reson
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79274928e133e35f598e7b39d2119634