Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Erin P. Smith"'
Autor:
Erin P. Smith, Alexis Cotto-Rosario, Elizabeth Borghesan, Kiara Held, Cheryl N. Miller, Jean Celli
Publikováno v:
mBio, Vol 11, Iss 2 (2020)
ABSTRACT Intracellular bacterial pathogens remodel cellular functions during their infectious cycle via the coordinated actions of effector molecules delivered through dedicated secretion systems. While the function of many individual effectors is kn
Externí odkaz:
https://doaj.org/article/f7dfe2eccd2248279ea9482b3b7e79ea
Publikováno v:
Genetics Selection Evolution, Vol 56, Iss 1, Pp 1-15 (2024)
Abstract Background The effects of environmental disturbances on livestock are often observed indirectly through the variability patterns of repeated performance records over time. Sheep are frequently exposed to diverse extensive environments but cu
Externí odkaz:
https://doaj.org/article/7f13ab4362f3468e8cca50b7d167ea28
Publikováno v:
mBio, Vol 7, Iss 6 (2016)
ABSTRACT Brucella abortus, the bacterial agent of the worldwide zoonosis brucellosis, primarily infects host phagocytes, where it undergoes an intracellular cycle within a dedicated membrane-bound vacuole, the Brucella-containing vacuole (BCV). Initi
Externí odkaz:
https://doaj.org/article/42b8300053ea47208c46580f0162ca5f
Publikováno v:
Cognitive Research, Vol 9, Iss 1, Pp 1-17 (2024)
Abstract Multilingual speakers can find speech recognition in everyday environments like restaurants and open-plan offices particularly challenging. In a world where speaking multiple languages is increasingly common, effective clinical and education
Externí odkaz:
https://doaj.org/article/ac1eb0483e284b829e2f4c6c796d5fde
Autor:
Liam Mahedy, Emma L. Anderson, Kate Tilling, Zak A. Thornton, Andrew R. Elmore, Sándor Szalma, Arthur Simen, Meredith Culp, Stephen Zicha, Brian T. Harel, George Davey Smith, Erin N. Smith, Lavinia Paternoster
Publikováno v:
Translational Psychiatry, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Cognitive decline is a major health concern and identification of genes that may serve as drug targets to slow decline is important to adequately support an aging population. Whilst genetic studies of cross-sectional cognition have been carr
Externí odkaz:
https://doaj.org/article/7c74e97413254aebba9b6708c2e881d5
Autor:
Natalie E. Ebeling‐Koning, David Goodman, Alexandra M. Amaducci, Erin S. Smith, Ryan M. Surmaitis, Kenneth D. Katz, Andrew L. Koons, Derek J. Fikse, Matthew Ferdock, Marna Rayl Greenberg, Matthew D. Cook
Publikováno v:
Journal of the American College of Emergency Physicians Open, Vol 5, Iss 3, Pp n/a-n/a (2024)
Abstract Objectives Phenobarbital (PB) is a long‐acting GABA A‐agonist with favorable pharmacokinetics (long half‐life and duration of effect) that allows effective treatment of alcohol withdrawal (AW) after administration of a single loading d
Externí odkaz:
https://doaj.org/article/683326156a714c6cada8375066cf703c
Autor:
Erin D. Smith, Andrea E. Kirkwood
Publikováno v:
FACETS, Vol 8, Iss , Pp 1-12 (2023)
In 2020, the COVID-19 pandemic interrupted all aspects of human activity, including environmental research and monitoring. Despite a lack of laboratory access and other restrictive measures, we adapted an existing community science monitoring program
Externí odkaz:
https://doaj.org/article/3e00703e99534bcb8a1321252d971a34
Publikováno v:
Cell Reports, Vol 42, Iss 5, Pp 112448- (2023)
Summary: Gain-of-function mutations in the LRRK2 gene cause Parkinson’s disease (PD), increasing phosphorylation of RAB GTPases through hyperactive kinase activity. We find that LRRK2-hyperphosphorylated RABs disrupt the axonal transport of autopha
Externí odkaz:
https://doaj.org/article/0e1af3ea98cc466fb9c9dea8dce782a5
Autor:
Agnieszka D'Antonio-Chronowska, Margaret K.R. Donovan, William W. Young Greenwald, Jennifer Phuong Nguyen, Kyohei Fujita, Sherin Hashem, Hiroko Matsui, Francesca Soncin, Mana Parast, Michelle C. Ward, Florence Coulet, Erin N. Smith, Eric Adler, Matteo D'Antonio, Kelly A. Frazer
Publikováno v:
Stem Cell Reports, Vol 13, Iss 5, Pp 924-938 (2019)
Summary: Despite the importance of understanding how variability across induced pluripotent stem cell (iPSC) lines due to non-genetic factors (clone and passage) influences their differentiation outcome, large-scale studies capable of addressing this
Externí odkaz:
https://doaj.org/article/8f78689b27d04687908913946f7fa60e
Autor:
Erin N. Smith, Agnieszka D'Antonio-Chronowska, William W. Greenwald, Victor Borja, Lana R. Aguiar, Robert Pogue, Hiroko Matsui, Paola Benaglio, Shyamanga Borooah, Matteo D'Antonio, Radha Ayyagari, Kelly A. Frazer
Publikováno v:
Stem Cell Reports, Vol 12, Iss 6, Pp 1342-1353 (2019)
Summary: We evaluate whether human induced pluripotent stem cell-derived retinal pigment epithelium (iPSC-RPE) cells can be used to prioritize and functionally characterize causal variants at age-related macular degeneration (AMD) risk loci. We gener
Externí odkaz:
https://doaj.org/article/9c34a3ce8fe74c1c8d965a279b15f664