Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Erin P. Keaney"'
Autor:
Benoit Bilanges, Samira Alliouachene, Wayne Pearce, Daniele Morelli, Gyorgy Szabadkai, Yuen-Li Chung, Gaëtan Chicanne, Colin Valet, Julia M. Hill, Peter J. Voshol, Lucy Collinson, Christopher Peddie, Khaled Ali, Essam Ghazaly, Vinothini Rajeeve, Georgios Trichas, Shankar Srinivas, Claire Chaussade, Rachel S. Salamon, Jonathan M. Backer, Cheryl L. Scudamore, Maria A. Whitehead, Erin P. Keaney, Leon O. Murphy, Robert K. Semple, Bernard Payrastre, Sharon A. Tooze, Bart Vanhaesebroeck
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Vps34 is a lipid kinase conserved from yeast to humans and involved in in intracellular vesicular trafficking and autophagy. Here Bilanges et al. show that inhibition of this kinase in mice improves glucose tolerance and diet-induced steatosis by mod
Externí odkaz:
https://doaj.org/article/555f2b0adcb149a18a070a3da3035320
Autor:
Noel Marie-France Thomsen, Simone Bonazzi, Stephanie M. McTighe, Guiqing Liang, Danuta Lubicka, Sarah Salas, Jill Nunez, Franco Lombardo, Rajeshri Ganesh Karki, Audrey Gray, Stefan Peukert, Doug Burdette, Jean-Cosme Dodart, Leon Murphy, Grazia Piizzi, Carleton Goold, Labbe-Giguere Nancy, Erin P. Keaney, Jonathan D. Biag, Christine D. Wilson, Aakruti Gorde, Lawrence G. Hamann, Yingchuan Sun, Lin Deng, Hasnain A. Malik, Daniel Curtis, Shanming Liu
Publikováno v:
Journal of medicinal chemistry. 63(3)
Recent clinical evaluation of everolimus for seizure reduction in patients with tuberous sclerosis complex (TSC), a disease with overactivated mechanistic target of rapamycin (mTOR) signaling, has demonstrated the therapeutic value of mTOR inhibitors
Autor:
Orianne Olivares, Arunima Mukhopadhyay, Elodie M. Kuntz, Tessa L. Holyoake, Leon Murphy, Ravi K. Amaravadi, Eyal Gottlieb, Mary T. Scott, Amy Dawson, Jeffrey D. Winkler, Erin P. Keaney, Karen Dunn, Rebecca Mitchell, G. Vignir Helgason, Pablo Baquero, Michael C. Nicastri, Kevin M. Ryan, Christina Halsey, Angela Ianniciello, Alison M. Michie
Publikováno v:
Leukemia
In chronic myeloid leukemia (CML), tyrosine kinase inhibitor (TKI) treatment induces autophagy that promotes survival and TKI-resistance in leukemic stem cells (LSCs). In clinical studies hydroxychloroquine (HCQ), the only clinically approved autopha
Autor:
Christine Moore, Brant Firestone, Erin P. Keaney, Dmitri Wiedershain, William E. Dowdle, Pascal Furet, Wieslawa Maniara, Edmund Harrington, Meir Glick, Ellen Triantafellow, Lawrence G. Hamann, Ivan Cornella-Taracido, Mark Knapp, Ayako Honda, Leon Murphy, Peter Finan
Publikováno v:
ACS Medicinal Chemistry Letters. 7:72-76
Autophagy is a dynamic process that regulates lysosomal-dependent degradation of cellular components. Until recently the study of autophagy has been hampered by the lack of reliable pharmacological tools, but selective inhibitors are now available to
Autor:
Stephen B. Helliwell, Ayako Honda, Jane Nagel, Xiaohong Mao, Debra Burdick, Julie Bastien, Henry Wang, Suchithra Menon, Hong Lei, Robert Elling, William E. Dowdle, Dirksen E. Bussiere, Mary Ellen Digan, Lawrence G. Hamann, Ivan Cornella-Taracido, Beat Nyfeler, David Schwalb, Dmitri Wiederschain, Savuth Ugwonali, Fred Harbinski, Markus Schirle, Peter Fekkes, Christine D. Wilson, Shanming Liu, Thomas B. Nicholson, Edmund Harrington, Jason R. Thomas, Reginald Valdez, Vic E. Myer, Brendan D. Manning, Erin P. Keaney, John A. Tallarico, Peter Finan, Mark Labow, Gwynn Pardee, Simon D’Aquin, Andrew F. Powers, John Cantwell, Philip Bergman, Qing Fang, Leon Murphy, Zuncai Wang, Mark Knapp, Jenny Kuerth, Ellen Triantafellow, Catherine Luu, Jeffery A. Porter
Publikováno v:
Nature Cell Biology. 16:1069-1079
Cells rely on autophagy to clear misfolded proteins and damaged organelles to maintain cellular homeostasis. In this study we use the new autophagy inhibitor PIK-III to screen for autophagy substrates. PIK-III is a selective inhibitor of VPS34 that b
Autor:
Michael D. Connolly, Matthew J. LaMarche, Lawrence G. Hamann, Ayako Honda, Brigitte Wiedmann, Subramanian Karur, Shawn D. Britt, Markus Dobler, Rajeshri Ganesh Karki, Prakash Raman, Anup Patnaik, Samantha Sokup, Erin P. Keaney
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:3714-3718
Synthesis and SAR of 2-alkyloxazoles as class III phosphatidylinositol-4-kinase beta (PI4KIIIβ) inhibitors is described. These compounds demonstrate that inhibition of PI4KIIIβ leads to potent inhibition of HCV replication as observed in genotype (
Autor:
Janetta Dewhurst, Branko Radetich, Gerard Joberty, Lawrence G. Hamann, Erin P. Keaney, Kara Balabanis, Jian Shao, Keith Hoffmaster, Tommasi Ruben A, Ivan Cornella-Taracido, Tewis Bouwmeester, Michael Franti, Aurelio Bonavia, Bushell Simon, Leanne Lanieri, Teresa Compton, Mohindra Seepersaud, Jakal Amin, Michelle Broome, John A. Tallarico, Colin P. Osborne, Elizabeth Skuba, Judit Markovits, Ayako Honda, James Monroe, Karen Wolff, Kelli Kuhen
Publikováno v:
Proceedings of the National Academy of Sciences. 108:6739-6744
The search for novel therapeutic interventions for viral disease is a challenging pursuit, hallmarked by the paucity of antiviral agents currently prescribed. Targeting of viral proteins has the inextricable challenge of rise of resistance. Safe and
Autor:
Steven Fletcher, Erin Pusateri Keaney, Christopher G. Cummings, Michelle A. Blaskovich, Michael A. Hast, Matthew P. Glenn, Sung-Youn Chang, Cynthia J. Bucher, Ryan J. Floyd, William P. Katt, Michael H. Gelb, Wesley C. Van Voorhis, Lorena S. Beese, Said M. Sebti, Andrew D. Hamilton
Publikováno v:
Journal of Medicinal Chemistry; Oct2010, Vol. 53 Issue 19, p6867-6888, 22p