Neoadjuvant T-DM1/pertuzumab and paclitaxel/trastuzumab/pertuzumab for HER2+ breast cancer in the adaptively randomized I-SPY2 trial

Autor: Amy S. Clark, Christina Yau, Denise M. Wolf, Emanuel F. Petricoin, Laura J. van ‘t Veer, Douglas Yee, Stacy L. Moulder, Anne M. Wallace, A. Jo Chien, Claudine Isaacs, Judy C. Boughey, Kathy S. Albain, Kathleen Kemmer, Barbara B. Haley, Hyo S. Han, Andres Forero-Torres, Anthony Elias, Julie E. Lang, Erin D. Ellis, Rachel Yung, Debu Tripathy, Rita Nanda, Julia D. Wulfkuhle, Lamorna Brown-Swigart, Rosa I. Gallagher, Teresa Helsten, Erin Roesch, Cheryl A. Ewing, Michael Alvarado, Erin P. Crane, Meredith Buxton, Julia L. Clennell, Melissa Paoloni, Smita M. Asare, Amy Wilson, Gillian L. Hirst, Ruby Singhrao, Katherine Steeg, Adam Asare, Jeffrey B. Matthews, Scott Berry, Ashish Sanil, Michelle Melisko, Jane Perlmutter, Hope S. Rugo, Richard B. Schwab, W. Fraser Symmans, Nola M. Hylton, Donald A. Berry, Laura J. Esserman, Angela M. DeMichele

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)

HER2-targeted therapy improves patient’s outcome in early breast cancer. Here, the authors present the efficacy and biomarker analysis of two HER2-targeted combinations (ado-trastuzumab emtansine plus pertuzumab and paclitaxel, trastuzumab and pert

Externí odkaz: https://doaj.org/article/e6340916dac6476fac8b24ed5afd32c1

Breast MRI during Neoadjuvant Chemotherapy: Lack of Background Parenchymal Enhancement Suppression and Inferior Treatment Response

Autor: Erin P. Crane, An L Church, Dae Hee Bang, Charlotte Dillis, Bethany L. Niell, Angela DeMichele, Marisa H. Borders, Basak E. Dogan, Jennifer S. Drukteinis, Deepa Sheth, Wei Tse Yang, Stefanie Woodard, Mark A. Rosen, Lisa J. Wilmes, Christina Yau, Natsuko Onishi, David C. Newitt, Theresa Kuritza, Jessica Gibbs, Despina Kontos, Marina E. Giurescu, Ella F. Jones, Thomas L. Chenevert, Mohammad Eghtedari, Roy Harnish, Constance D. Lehman, Fredrik Strand, Vignesh A. Arasu, Bruce Porter, Linda Hovanessian-Larsen, Alex Anh-Tu Nguyen, Elise Berman, Hiroyuki Abe, Mary S. Newell, Neda Jafarian, Laura J. Esserman, Savannah C. Partridge, John Kornak, Kelly Fountain, Luminita A. Tudorica, Donald A. Berry, Patrick J Bolan, Michael Nelson, Sally Goudreau, Kathleen M. Ward, Kimberly A. Fitzpatrick, Karen Y. Oh, Bonnie N. Joe, Lara Hardesty, Kevin Morley, Kathleen R. Brandt, Haydee Ojeda-Fournier, Dan Lopez Paniagua, Heidi Umphrey, Elissa R Price, Elizabeth S. McDonald, Wen Li, Pulin Sheth, Dulcy Wolverton, Nola M. Hylton, Kathryn W Zamora

Publikováno v: Radiology, vol 301, iss 2

Background Suppression of background parenchymal enhancement (BPE) is commonly observed after neoadjuvant chemotherapy (NAC) at contrast-enhanced breast MRI. It was hypothesized that nonsuppressed BPE may be associated with inferior response to NAC.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9d4b2fa9b1d86431fe0443e020f3903
https://doi.org/10.1148/radiol.2021203645

Evaluation of the Viability of Untreated Leiomyomas Using Computed Tomography-Detected Calcification Patterns

Autor: Erin P. Crane, Edward P. Fenlon, Susan M. Ascher, Dhiksha Balaji, Evan S. Siegelman

Publikováno v: Journal of computer assisted tomography. 46(1)

To evaluate the relationship between computed tomography (CT)-detected calcification patterns and Magnetic Resonance Imaging (MRI) enhancement as a surrogate for viability in untreated uterine leiomyomas.We queried 2 university hospital databases to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::087ca824d8472e90a68f6b816839dc64
https://pubmed.ncbi.nlm.nih.gov/35099130

Abstract P2-07-03: Refining neoadjuvant predictors of three year distant metastasis free survival: Integrating volume change as measured by MRI with residual cancer burden

Autor: Melissa Paoloni, A Magliocco, W Yang, AD Elias, Mark A. Rosen, H Sattar, AS Clark, Jane Perlmutter, Gillian L. Hirst, Sy Chui, KA Ward, Richard Schwab, Anne M. Wallace, B Chen, AM DeMichele, Michael D. Nelson, Michael Feldman, L.J. van 't Veer, Scott M. Berry, Y-Y Chen, Amy Wilson, Larissa A. Korde, Lajos Pusztai, Haydee Ojeda-Fournier, O Fadare, Brian Datnow, W K Bernreuter, PK Haugen, H Abe, Rebecca K. Viscusi, M. Melisko, K Oh, Molly Klein, W Li, Julia L. Clennell, C Yau, S. L. Moulder, G Krings, Judy C. Boughey, Rita Nanda, David M. Euhus, Heather Beckwith, Heidi Umphrey, S Wei, Nola M. Hylton, C Isaacs, Donald A. Berry, Ruby Singhrao, AJ Chien, William Fraser Symmans, Erica Stringer-Reasor, Erin D. Ellis, Qamar J. Khan, S Yang, O. I. Olopade, P Mhawech-Fauceglia, Meredith Buxton, Jeffrey B. Matthews, T Vinh, Hyo S. Han, Adam Asare, M Rendi, C Hatzis, Shelly S. Lo, Janice Lu, Donald W. Northfelt, Debu Tripathy, Pulin Sheth, DH Bang, Dulcy Wolverton, Bethany L. Niell, K Adamson, Ashish Sanil, HS Rugo, Kathy R. Brandt, S Sams, Je Lang, Mohammad Eghtedari, Teresa Helsten, S Sahoo, William C. Wood, Minetta C. Liu, Katherine Steeg, John W. Park, A Ferero-Torres, Erin P. Crane, J Zeck, Douglas Yee, A Adams, Ossama Tawfik, L Grasso LeBeau, Stefan E. Pambuccian, I Ocal, Kathleen Kemmer, KS Albain, Basak E. Dogan, Bonnie N. Joe, Kirsten K. Edmiston, LJ Esserman, Garry Peterson, S Asare, Shuko Harada

Publikováno v: Cancer Research. 79:P2-07

Background: Patients achieving a pathologic complete response (pCR) following neoadjuvant therapy have significantly improved event-free survival relative to those who do not; and pCR is an FDA-accepted endpoint to support accelerated approval of nov

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0a650c67d6e1172919fb7c74efc7490c
https://doi.org/10.1158/1538-7445.sabcs18-p2-07-03

Imaging and Management of Unusual Breast Neoplasms

Autor: Suzanne M. Smith Iorfido, Erini Makariou, Janice Y. Jeon, Shawna C. Willey, Erin P Crane

Publikováno v: Contemporary Diagnostic Radiology. 41:1-5

Unusual breast neoplasms encompass a host of heterogeneous benign, borderline, and malignant entities, which often pose a management challenge when encountered on pathologic analysis after image-guided biopsy. Entities to be discussed in this article

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da8818663808279632cfe78f7373e008
https://doi.org/10.1097/01.cdr.0000533586.18486.07