Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Erin Nguyen"'
Ensemble-based enzyme design can recapitulate the effects of laboratory directed evolution in silico
Autor:
Aron Broom, Rojo V. Rakotoharisoa, Michael C. Thompson, Niayesh Zarifi, Erin Nguyen, Nurzhan Mukhametzhanov, Lin Liu, James S. Fraser, Roberto A. Chica
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Kemp eliminases are artificial enzymes that catalyze the concerted deprotonation and ring-opening of benzisoxazoles. Here, the authors use room-temperature X-ray crystallography to investigate changes to the conformational ensemble of the Kemp elimin
Externí odkaz:
https://doaj.org/article/7439f4de0efc41d198a2176b909a8ff0
Publikováno v:
Ecosphere, Vol 12, Iss 9, Pp n/a-n/a (2021)
Abstract The natural flow regime (NFR) paradigm posits that naturally occurring temporal fluctuations in streamflow are necessary for maintaining natural ecological communities. Conservation actions guided by the paradigm have contributed to stream o
Externí odkaz:
https://doaj.org/article/4a5d3924c54c4398b2f509ec691b7912
Publikováno v:
North American Journal of Fisheries Management.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe439ad97782343d41dbd29138860fdd
https://doi.org/10.1002/nafm.10874
https://doi.org/10.1002/nafm.10874
Ensemble-based enzyme design can recapitulate the effects of laboratory directed evolution in silico
Autor:
Lin Liu, Michael C. Thompson, Niayesh Zarifi, Erin Nguyen, Aron Broom, Rojo V Rakotoharisoa, Nurzhan Mukhametzhanov, James S. Fraser, Roberto A. Chica
Publikováno v:
Nature communications, vol 11, iss 1
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Nature Communications
The creation of artificial enzymes is a key objective of computational protein design. Although de novo enzymes have been successfully designed, these exhibit low catalytic efficiencies, requiring directed evolution to improve activity. Here, we use
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27d365dfb9700690fb0ebca00b84ea69
https://escholarship.org/uc/item/0z88f0sj
https://escholarship.org/uc/item/0z88f0sj
Autor:
Michael C. Thompson, Mukhametzhanov N, Erin Nguyen, Lin Liu, Aron Broom, R.V. Rakotoharisoa, James S. Fraser, Roberto A. Chica, Zarifi N
The creation of artificial enzymes is a key objective of computational protein design. Although de novo enzymes have been successfully designed, these exhibit low catalytic efficiencies, requiring directed evolution to improve activity. Here, we used
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff9f346c2710e9bb37961af65f018731
https://doi.org/10.1101/2020.03.19.999235
https://doi.org/10.1101/2020.03.19.999235
Publikováno v:
University of Ottawa Science Undergraduate Research Journal. 1:10-14
Red fluorescent proteins (RFPs) are genetically-encoded fluorophores that are widely used for in vivo imaging. For all applications of RFPs, brighter variants are desired. Previously, we improved the brightness of mRojoA, a red-shifted mutant of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::70dfe9eaca9633a600052e4792459c95
https://doi.org/10.18192/osurj.v1i1.3666
https://doi.org/10.18192/osurj.v1i1.3666
Autor:
Jason Zybert, Bilal Piperdi, Erin Nguyen, Steven H. Wolfe, Traci M. Dutton, David C. Gammon, Venu G. Pillarisetty, Dalia Sbat, Mary E. Sullivan, Giles F. Whalen
Publikováno v:
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists. 66(13)
Purpose. Cytoreductive surgery (CS) and intraperitoneal hyperthermic chemotherapy (IPHC) in the treatment of peritoneal carcinomatosis (PC) in 15 patients are described. Summary. Fifteen patients with PC who were treated with CS and IPHC were retrosp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f948632f4155610e3a13e19304dce1a
https://pubmed.ncbi.nlm.nih.gov/19535657
https://pubmed.ncbi.nlm.nih.gov/19535657