Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Erin N. Potts-Kant"'
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e27137 (2011)
Ozone exposure is associated with exacerbation of reactive airways disease. We have previously reported that the damage-associated molecular pattern, hyaluronan, is required for the complete biological response to ambient ozone and that hyaluronan fr
Externí odkaz:
https://doaj.org/article/545aa47d54c74b10aad7a7c775c3541f
Autor:
Richard L. Auten, Chang Won Choi, Mulugu V. Brahmajothi, Beyong Il Kim, Erin N. Potts-Kant, Stanley N. Mason
Publikováno v:
Pediatric Research
Background: We previously showed that intra-amniotic lipopolysaccharide (LPS) amplifies alveolar hypoplasia induced by postnatal hyperoxia. We determined whether the priming effect of intra-amniotic LPS amplifies hyperoxia-induced airway hyperreactiv
Autor:
Benjamin W. Frush, James Y. Lindsey, John W. Hollingsworth, Erin N. Potts-Kant, Robert M. Tighe, W. Michael Foster, Zhuowei Li
Publikováno v:
Free radical biologymedicine. 113
Emphysema is currently a leading cause of mortality with no known effective therapy to attenuate progressive loss of lung function. Previous work support that activation of nuclear factor erythroid 2-related factor 2 (Nrf2) is protective to the lung
Autor:
Erin N. Potts-Kant, Apparao B. Kummarapurugu, Andrew J. Ghio, Bernard M. Fischer, Laura G. Dubois, Shuo Zheng, Erik J. Soderblom, M. Arthur Moseley, Ginger L. Milne, J. Will Thompson, Judith A. Voynow, W. Michael Foster
Publikováno v:
Journal of Biological Chemistry. 288:4681-4691
NADPH quinone oxidoreductase 1 (NQO1) is recognized as a major susceptibility gene for ozone-induced pulmonary toxicity. In the absence of NQO1 as can occur by genetic mutation, the human airway is protected from harmful effects of ozone. We recently
Autor:
Yiming Wu, Feifei Feng, Zhuowei Li, John W. Hollingsworth, W. Michael Foster, Erin N. Potts-Kant, Kristi L. Williams
Publikováno v:
Environmental Health Perspectives
Background: The role of the Nlrp3 inflammasome in nonallergic airway hyperresponsiveness (AHR) has not previously been reported. Recent evidence supports both interleukin (IL) 1β and short fragments of hyaluronan (HA) as contributors to the biologic
Autor:
John W. Hollingsworth, Monica Kraft, Druhan L. Howell, Sin-Ho Jung, Jennifer L. Ingram, Tony D. Church, Erin N. Potts-Kant, Ying Wang, Njira L Lugogo, Loretta G. Que, Dave Francisco
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 186:404-411
Rationale: Obesity is associated with increased prevalence and severity of asthma. Adipose tissue macrophages can contribute to the systemic proinflammatory state associated with obesity. However, it remains unknown whether alveolar macrophages have
Autor:
James Y. Lindsey, W. Michael Foster, Zhuowei Li, Benjamin W. Frush, Erin N. Potts-Kant, Robert M. Tighe, John W. Hollingsworth
Publikováno v:
Free Radical Biology and Medicine. 52:705-715
Chronic obstructive pulmonary disease (COPD) is the fourth major cause of death in the United States and the only disease in the top ten causes of death with a rising incidence in the United States [1]. COPD is a slowly progressive disease characteri
Autor:
Vinayak S. Nikam, Erin N. Potts-Kant, Jo Rae Wright, Njira L Lugogo, Monica Kraft, W. Michael Foster, Bethany J. Hsia, Soman N. Abraham, Julie G. Ledford
Publikováno v:
Journal of Allergy and Clinical Immunology. 137:336
Autor:
Chang Won Choi, Beyong Il Kim, Stanley N. Mason, Mulugu V. Brahmajothi, Erin N. Potts-Kant, Richard L. Auten
Publikováno v:
Pediatric Research
We previously showed that intra-amniotic lipopolysaccharide (LPS) amplifies alveolar hypoplasia induced by postnatal hyperoxia. We determined whether the priming effect of intra-amniotic LPS amplifies hyperoxia-induced airway hyperreactivity (AHR). L
Autor:
Bernard M. Fischer, Erin N. Potts-Kant, Judith A. Voynow, Andrew J. Ghio, W. Michael Foster, Marisa Meyer
Publikováno v:
American journal of physiology. Lung cellular and molecular physiology. 303(3)
Mucous cell metaplasia (MCM) and neutrophil-predominant airway inflammation are pathological features of chronic inflammatory airway diseases. A signature feature of MCM is increased expression of a major respiratory tract mucin, MUC5AC. Neutrophil e