Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Erin N. Hancock"'
Autor:
Rachel C. Epplin, Shashwati Paul, Loïc Herter, Christophe Salome, Erin N. Hancock, Jay F. Larrow, Erich W. Baum, David R. Dunstan, Carol Ginsburg-Moraff, Thomas C. Fessard, M. Kevin Brown
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-5 (2022)
The development of new classes of isosteres and building blocks is crucial to the advancement of medicinal chemistry programs. Here, the authors report the synthesis and development of ladderanes to act as replacements for meta-substituted aromatic r
Externí odkaz:
https://doaj.org/article/ebd0a84e99d044029fceee6ab73bf297
Autor:
Erin N. Hancock, M. Kevin Brown
Publikováno v:
Chemistry
The ladderane family of natural products are well known for their linearly concatenated cyclobutane skeletal structure. Owing to their unique carbocyclic framework, several chemical syntheses have been reported since their discovery in 2002. The focu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83e677b68fb2ae5065d0510201a4629d
https://pubmed.ncbi.nlm.nih.gov/33463810
https://pubmed.ncbi.nlm.nih.gov/33463810
Publikováno v:
Angewandte Chemie (International ed. in English), vol 59, iss 1
Angew Chem Int Ed Engl
Angew Chem Int Ed Engl
The synthesis of structurally complex and highly strained natural products provides unique challenges and unexpected opportunities for the development of new reactions and strategies. Herein, the synthesis of (+)-[5]-ladderanoic acid is reported. En
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45487599d309fb1bdcfd820ee611a986
https://escholarship.org/uc/item/4nf6x1jq
https://escholarship.org/uc/item/4nf6x1jq
Publikováno v:
Nat Prod Rep
Covering: January 2000 to July 2018 gem-Dimethylcyclobutanes are a common motif found in a multitude of natural products, and thus these structures have captivated synthetic chemists for years. However, until the turn of the century, most synthetic e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f8b58d59a16eacd8b1961dd8bc86f57
https://europepmc.org/articles/PMC6739199/
https://europepmc.org/articles/PMC6739199/
Autor:
Kristina A. Scott, Heather R. Morgan, Matthew M. Tierney, Erin N. Hancock, Alexander C. Brueckner, Evan J. Anders, Angus A. Lamar
Publikováno v:
Organic & Biomolecular Chemistry. 14:4387-4392
A mild and operationally convenient amino-functionalization of a range of tertiary alkyl halides by reaction with iminoiodinanes (PhI[double bond, length as m-dash]NNs) and I2 has been developed. According to the mechanistic experiments described wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ec58b52baba4b26256f0c294f022735
https://doi.org/10.1039/c6ob00616g
https://doi.org/10.1039/c6ob00616g
An enantioselective synthesis of ent-[3]-ladderanol is presented. The ladderanes are an interesting class of molecules for their unique structure of fused cyclobutane rings as well as their perceived biological function of organism protection. The ro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2dee71656404958a18971457da90ebd
https://europepmc.org/articles/PMC5704961/
https://europepmc.org/articles/PMC5704961/
Autor:
Heather R. Morgan, Erin N. Hancock, Matthew M. Tierney, Evan J. Anders, Angus A. Lamar, Kristina A. Scott, Alexander C. Brueckner
Publikováno v:
ChemInform. 47
A mild and operationally convenient amino-functionalization of a range of tertiary alkyl halides by reaction with iminoiodinanes (PhINNs) and I2 has been developed. According to the mechanistic experiments described within, the reaction is speculated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25dfaa73082c38e52bdcf2e4453d7b02
https://doi.org/10.1002/chin.201638054
https://doi.org/10.1002/chin.201638054
Autor:
Rachel C. Epplin, Shashwati Paul, Loïc Herter, Christophe Salome, Erin N. Hancock, Jay F. Larrow, Erich W. Baum, David R. Dunstan, Carol Ginsburg-Moraff, Thomas C. Fessard, M. Kevin Brown
Publikováno v:
Nature Communications
Aromatic ring isosteres and rigidified saturated hydrocarbons are important motifs to enable drug discovery. Herein we disclose [2]-ladderanes as a class of meta-substituted aromatic ring isosteres and rigidified cyclohexanes. A straightforward synth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::704a6408ecb9323c10f1b4ad9e111357