Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Erin N. Guidry"'
Autor:
Anna Fryszkowska, Chihui An, Oscar Alvizo, Goutami Banerjee, Keith A. Canada, Yang Cao, Duane DeMong, Paul N. Devine, Da Duan, David M. Elgart, Iman Farasat, Donald R. Gauthier, Erin N. Guidry, Xiujuan Jia, Jongrock Kong, Nikki Kruse, Katrina W. Lexa, Alexey A. Makarov, Benjamin F. Mann, Erika M. Milczek, Vesna Mitchell, Jovana Nazor, Claudia Neri, Robert K. Orr, Peter Orth, Eric M. Phillips, James N. Riggins, Wes A. Schafer, Steven M. Silverman, Christopher A. Strulson, Nandhitha Subramanian, Rama Voladri, Hao Yang, Jie Yang, Xiang Yi, Xiyun Zhang, Wendy Zhong
Publikováno v:
Science (New York, N.Y.). 376(6599)
The emergence of new therapeutic modalities requires complementary tools for their efficient syntheses. Availability of methodologies for site-selective modification of biomolecules remains a long-standing challenge, given the inherent complexity and
Autor:
Adam Procopio, Akhilesh Bhambhani, Brian K. Meyer, Kristin J. M. Ploeger, Robert F. Meyer, Yash Kapoor, Erin N. Guidry, Allen C. Templeton, James DiNunzio, Justin Stanbro, Gregory M. Troup
Publikováno v:
Journal of Pharmaceutical Innovation. 16:2-10
Flexible manufacturing systems are needed in the pharmaceutical industry due to the future challenges of volatility, uncertainty, complexity, and ambiguity [1]. Compared to traditional manufacturing systems that dominate the pharmaceutical industry t
Autor:
Laura Sepp-Lorenzino, Hangchun Zhang, Yi Pei, South Victoria J, Steven L. Colletti, Wonsuk Chang, Daniel Zewge, Matthew G. Stanton, Jillian DiMuzio, Edward C. Sherer, Craig A. Parish, Erin N. Guidry, Walter Strapps
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:4513-4517
Single-stranded silencing RNAs (ss siRNA), while not as potent as duplex RNAs, have the potential to become a novel platform technology in RNA interference based gene silencing by virtue of their simplicity and plausibly favorable characteristics in
Publikováno v:
Microchemical Journal. 124:668-674
Quantification of oligonucleotides is commonly performed by UV absorption or fluorescence based assays. However, chemical modifications may change the UV absorbance or fluorescence of oligonucleotides, making their accurate quantification difficult.
Autor:
Rong Xiang, Tao Pei, Stephanie E. Barrett, J. Michael Williams, Robert M. Garbaccio, Erin N. Guidry, Jing Liao
Publikováno v:
Journal of Polymer Science Part A: Polymer Chemistry. 54:311-315
Autor:
Quang Truong, Conrad E. Raab, Michael J. Lyman, Andrew H. Latham, Haihong Fan, Eileen S. Walsh, Marissa Vavrek, Robert M. Garbaccio, Eric Kemp, Marc Abrams, Erin N. Guidry, Tao Pei, Steven L. Colletti, Laura Sepp-Lorenzino, Edward J. Carlini, Carol Bason, Melissa Stern, J. Michael Williams, Eric D. Soli, Rob S. Burke, Mihir Patel, Jun H. Heo, Brian A. Carr, Stephanie Young, Jacob H. Waldman, Sean Riley, Nicole T. Pudvah, Louis S. Crocker, Bonnie J. Howell, Sergey Pechenov, Steven J. Staskiewicz, Sheri Smith, Marina Busuek, Rubina G. Parmar, Stephanie E. Barrett, Anthony Leone, Robert A. Kowtoniuk
Publikováno v:
Journal of Controlled Release. 183:124-137
The greatest challenge standing in the way of effective in vivo siRNA delivery is creating a delivery vehicle that mediates a high degree of efficacy with a broad therapeutic window. Key structure-activity relationships of a poly(amide) polymer conju
Autor:
Tao Pei, J. Michael Williams, Erin N. Guidry, Stephanie E. Barrett, Robert M. Garbaccio, Jacob H. Waldman, Caitlin M. DeAngelo, Robert A. Kowtoniuk
Publikováno v:
Journal of Polymer Science Part A: Polymer Chemistry. 52:1385-1391
Autor:
Bonnie J. Howell, Quang T. Truong, Anthony Leone, Rubina G. Parmar, Julie Farand, Stephanie E. Barrett, Arash Soheili, Robert M. Garbaccio, Steven L. Colletti, Nancy J. Kevin, Andrew H. Latham, Laura Sepp-Lorenzino, Brenda Pipik, Erin N. Guidry, Bing Mao, Craig A. Parish, Nori Ikemoto, Ian W. Davies, Jacob H. Waldman, Kathleen Calati
Publikováno v:
Bioconjugate Chemistry. 25:296-307
Polymer based carriers that aid in endosomal escape have proven to be efficacious siRNA delivery agents in vitro and in vivo; however, most suffer from cytotoxicity due in part to a lack of selectivity for endosomal versus cell membrane lysis. For po
Autor:
Klaus Charisse, Matthew G. Stanton, Christopher S. Theile, Kallanthottathil G. Rajeev, Rachel Meyers, Muthiah Manoharan, Laura Sepp-Lorenzino, Mark T. Cancilla, Rubina G. Parmar, Martin Maier, Walter Strapps, Yi Pei, Erin N. Guidry, Akin Akinc, Vasant Jadhav, Jennifer L. S. Willoughby, Donald Foster, Jingxuan Liu, Benjamin Brigham
Publikováno v:
Chembiochem : a European journal of chemical biology. 17(11)
Small interfering RNA (siRNA)-mediated silencing requires siRNA loading into the RNA-induced silencing complex (RISC). Presence of 5'-phosphate (5'-P) is reported to be critical for efficient RISC loading of the antisense strand (AS) by anchoring it
Autor:
Erin N. Guidry, Stephanie E. Barrett
Publikováno v:
Methods in Molecular Biology ISBN: 9781493931118
The realization of polymer conjugate-based RNA delivery as a clinical modality requires the development and optimization of novel formulations. Although many literature examples of polymer conjugate-based SiRNA delivery systems exist, the protocols d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::730ec1820245f210222e82e593aa1093
https://doi.org/10.1007/978-1-4939-3112-5_2
https://doi.org/10.1007/978-1-4939-3112-5_2