Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Erin Maxfield"'
Autor:
Alan J. Lerner, Steven E. Arnold, Erin Maxfield, Aaron Koenig, Maria E. Toth, Brooke Fortin, Natalia Mast, Bianca A. Trombetta, John Denker, Andrew A. Pieper, Curtis Tatsuoka, Sangeetha Raghupathy, Irina A. Pikuleva
Publikováno v:
Alzheimer’s Research & Therapy, Vol 14, Iss 1, Pp 1-10 (2022)
Abstract Background Efavirenz is an anti-HIV drug, and cytochrome P450 46A1 (CYP46A1) is a CNS-specific enzyme that metabolizes cholesterol to 24-hydroxycholesterol (24HC). We have previously shown that allosteric CYP46A1 activation by low-dose efavi
Externí odkaz:
https://doaj.org/article/be51f0c921904c6eb9b8ba7aa6a50ed7
Autor:
Alan J. Lerner, Steven E. Arnold, Erin Maxfield, Aaron Koenig, Maria E. Toth, Brooke Fortin, Natalia Mast, Bianca A. Trombetta, John Denker, Andrew A. Pieper, Curtis Tatsuoka, Sangeetha Raghupathy, Irina A. Pikuleva
Background: Efavirenz is an anti-HIV drug, and cytochrome P450 46A1 (CYP46A1) is a CNS-specific enzyme that metabolizes cholesterol to 24-hydroxycholesterol (24HC). We have previously shown that allosteric CYP46A1 activation by low-dose efavirenz in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f26ea50c83440c7aa8ab697533a08bd1
https://doi.org/10.21203/rs.3.rs-1348328/v1
https://doi.org/10.21203/rs.3.rs-1348328/v1
Autor:
H. V. Rasika Dias, Animesh Das, Naveen V. Kulkarni, Venkata A. K. Adiraju, Muhammed Yousufuddin, Erin Maxfield, Shawn G. Ridlen
Publikováno v:
Dalton Transactions. 45:4896-4906
Ethyl zinc complexes [N{(C3F7)C(Dipp)N}2]ZnEt, [N{(C3F7)C(Cy)N}2]ZnEt, [N{(CF3)C(2,4,6-Br3C6H2)N}2]ZnEt and [N{(C3F7)C(2,6-Cl2C6H3)N}2]ZnEt have been synthesized from the corresponding 1,3,5-triazapentadiene and diethyl zinc. X-ray data show that [N{
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59a785707cfd70b2dbd88245f776b63c
https://doi.org/10.1039/c6dt00257a
https://doi.org/10.1039/c6dt00257a
Autor:
Erin Maxfield, Natalia Mast, Irina A. Pikuleva, Alexey M. Petrov, Jean Moon, Young Li, Morrie Lam
Publikováno v:
SSRN Electronic Journal.
Efavirenz, the FDA-approved anti-retroviral medication, will soon be evaluated in the clinical trial in patients with mild cognitive impairment or early dementia due to Alzheimer's disease. Efavirenz will be assessed for activation of cytochrome P450
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a37acf19cb44b18b19fee981d9f25e8
https://doi.org/10.2139/ssrn.3284849
https://doi.org/10.2139/ssrn.3284849
Autor:
James Constans, Irina A. Pikuleva, Erin Maxfield, Natalia Mast, Young Li, Hiroyuki Arakawa, Ana Valencia-Olvera, Aicha Saadane, Gary E. Landreth
Publikováno v:
Neuropharmacology. 123
Cytochrome P450 46A1 (CYP46A1 or cholesterol 24-hydroxylase) controls cholesterol elimination from the brain and plays a role in higher order brain functions. Genetically enhanced CYP46A1 expression in mouse models of Alzheimer's disease mitigates th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e842ed3f27f3c0c6a5ae09c21100794
https://pubmed.ncbi.nlm.nih.gov/28655608
https://pubmed.ncbi.nlm.nih.gov/28655608