Zobrazeno 1 - 10
of 226
pro vyhledávání: '"Erin M. Schuman"'
Publikováno v:
FEBS Open Bio, Vol 13, Iss 7, Pp 1164-1176 (2023)
Gaining a mechanistic understanding of the molecular pathways underpinning cellular and organismal physiology invariably relies on the perturbation of an experimental system to infer causality. This can be achieved either by genetic manipulation or b
Externí odkaz:
https://doaj.org/article/edee7048f439482d907aa88e5e58f645
Autor:
Pietro Verzelli, Andreas Nold, Chao Sun, Mike Heilemann, Erin M. Schuman, Tatjana Tchumatchenko
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Single-molecule localization microscopy resolves objects below the diffraction limit of light via sparse, stochastic detection of target molecules. Single molecules appear as clustered detection events after image reconstruction. However, id
Externí odkaz:
https://doaj.org/article/4cf03207d65f47e09771456e5f3bb423
Autor:
Maximilian Seidel, Anja Becker, Filipa Pereira, Jonathan J. M. Landry, Nayara Trevisan Doimo de Azevedo, Claudia M. Fusco, Eva Kaindl, Natalie Romanov, Janina Baumbach, Julian D. Langer, Erin M. Schuman, Kiran Raosaheb Patil, Gerhard Hummer, Vladimir Benes, Martin Beck
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
The biogenesis of nuclear pores imposes a logistic challenge for cells. Here, the authors investigate structural motifs for co-translational interactions in nucleoporins and find that co-translational assembly events differ between paralogous assembl
Externí odkaz:
https://doaj.org/article/11fbfd960c6d41eaa79ad6eccdf62d07
Autor:
Claudia M. Fusco, Kristina Desch, Aline R. Dörrbaum, Mantian Wang, Anja Staab, Ivy C. W. Chan, Eleanor Vail, Veronica Villeri, Julian D. Langer, Erin M. Schuman
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Ribosomes, assembled in the nucleus and perinuclear region, are thought to remain invariant throughout their lifetime. Here the authors document the dynamic association or exchange of ribosomal proteins within mature ribosomes of neuronal cells.
Externí odkaz:
https://doaj.org/article/0daf9a60941a40fcad947dd5eda7d620
Autor:
Lukas Anneser, Anja Gemmer, Tim Eilers, Ivan C. Alcantara, Anett-Yvonn Loos, Soojin Ryu, Erin M. Schuman
Publikováno v:
iScience, Vol 25, Iss 3, Pp 103868- (2022)
Summary: Behavior is context-dependent and often modulated by an animal’s internal state. In particular, different social contexts can alter anxiety levels and modulate social behavior. The vertebrate-specific neuropeptide parathyroid hormone 2 (pt
Externí odkaz:
https://doaj.org/article/77826a777e504b769292716e133ccbd7
Publikováno v:
STAR Protocols, Vol 3, Iss 1, Pp 101063- (2022)
Summary: Cellular processes require tight and coordinated control of protein abundance, localization, and activity. One of the core mechanisms to achieve specific regulation of proteins is protein phosphorylation. Here we present a workflow to monito
Externí odkaz:
https://doaj.org/article/eda2b1ea95d8443c918800b66eca7348
Publikováno v:
Cell Reports, Vol 36, Iss 8, Pp 109583- (2021)
Summary: Homeostatic synaptic scaling allows for bi-directional adjustment of the strength of synaptic connections in response to changes in their input. Protein phosphorylation modulates many neuronal processes, but it has not been studied on a glob
Externí odkaz:
https://doaj.org/article/7691bf0013e14f0492ea24e45c647b2c
Autor:
Xi Wang, Xintian You, Julian D. Langer, Jingyi Hou, Fiona Rupprecht, Irena Vlatkovic, Claudia Quedenau, Georgi Tushev, Irina Epstein, Bernhard Schaefke, Wei Sun, Liang Fang, Guipeng Li, Yuhui Hu, Erin M. Schuman, Wei Chen
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
It is challenging to characterize diverse transcript isoforms by short-read sequencing. Here the authors report full-length transcriptomes in rat hippocampus by hybrid-sequencing, predict isoform-specific translational status, and reconstruct open re
Externí odkaz:
https://doaj.org/article/e648ad9d85e9487fb44af5a9caede55c
Autor:
Alexia Martínez de Paz, Leila Khajavi, Hélène Martin, Rafael Claveria-Gimeno, Susanne Tom Dieck, Manjinder S. Cheema, Jose V. Sanchez-Mut, Malgorzata M. Moksa, Annaick Carles, Nick I. Brodie, Taimoor I. Sheikh, Melissa E. Freeman, Evgeniy V. Petrotchenko, Christoph H. Borchers, Erin M. Schuman, Matthias Zytnicki, Adrian Velazquez-Campoy, Olga Abian, Martin Hirst, Manel Esteller, John B. Vincent, Cécile E. Malnou, Juan Ausió
Publikováno v:
Epigenetics & Chromatin, Vol 12, Iss 1, Pp 1-16 (2019)
Abstract Background MeCP2—a chromatin-binding protein associated with Rett syndrome—has two main isoforms, MeCP2-E1 and MeCP2-E2, differing in a few N-terminal amino acid residues. Previous studies have shown brain region-specific expression of t
Externí odkaz:
https://doaj.org/article/77c2d4837dd042b6b9fd1383b11eace4
Publikováno v:
iScience, Vol 20, Iss , Pp 237-247 (2019)
Summary: Circular RNAs (circRNAs), an important class of regulatory RNAs, have been shown to be the most prevalent in the brain compared with other tissues. However the processes governing their biogenesis in neurons are still elusive. Moreover, litt
Externí odkaz:
https://doaj.org/article/41027b3e4314425fa04a6355f0a27c9b