Výsledky vyhledávání - "Erin M. Mezzetti"

Nox2-Derived Superoxide Contributes to Cerebral Vascular Dysfunction in Diet-Induced Obesity

Autor: Xunxheng Chen, Frank M. Faraci, Adviye Ergul, Cynthia M. Lynch, Jessica A. Filosa, Erin M. Mezzetti, Shanshan Zhan, Sean P. Didion, Jessica L. Faulkner, Dale A. Kinzenbaw

Publikováno v: Stroke. 44:3195-3201

Background and Purpose— Obesity is an increasing epidemic worldwide; however, little is known about effects of obesity produced by high-fat diet (HFD) on the cerebral circulation. The purpose of this study was to examine the functional and temporal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61d07a94bf2f0799f99c5ee7672bb97c
https://doi.org/10.1161/strokeaha.113.001366

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Endothelin-1-mediated cerebrovascular remodeling is not associated with increased ischemic brain injury in diabetesThis article is one of a selection of papers published in the two-part special issue entitled 20 Years of Endothelin Research

Autor: Aisha I. Kelly-Cobbs, Weiguo LiW. Li, Susan C. Fagan, Adviye Ergul, Erin M. Mezzetti

Publikováno v: Canadian Journal of Physiology and Pharmacology. 88:788-795

Diabetes increases the risk of as well as poor outcome after stroke. Matrix metalloprotease (MMP) activation disrupts blood–brain barrier integrity after cerebral ischemia. We have previously shown that type 2 diabetes promotes remodeling of middle

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::65e78396f8d44b6acee65b0c2d7251f9
https://doi.org/10.1139/y10-040

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Differential Effects of Diet-Induced Dyslipidemia and Hyperglycemia on Mesenteric Resistance Artery Structure and Function in Type 2 Diabetes

Autor: Mostafa M. Elgebaly, Jimmie R. Hutchinson, Mong Heng Wang, Adviye Ergul, Erin M. Mezzetti, Kamakshi Sachidanandam

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 328:123-130

Type 2 diabetes and dyslipidemia oftentimes present in combination. However, the relative roles of diabetes and diet-induced dyslipidemia in mediating changes in vascular structure, mechanics, and function are poorly understood. Our hypothesis was th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c37b5dda303b58b7be43984994084b01
https://doi.org/10.1124/jpet.108.142612

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Effect of chronic and selective endothelin receptor antagonism on microvascular function in Type 2 diabetes

Autor: Vera Portik-Dobos, Alex K. Harris, Adviye Ergul, Erin M. Mezzetti, Mostafa M. Elgebaly, Kamakshi Sachidanandam, Jim R. Hutchinson

Publikováno v: American Journal of Physiology-Heart and Circulatory Physiology. 294:H2743-H2749

Vascular dysfunction, which presents either as an increased response to vasoconstrictors or an impaired relaxation to dilator agents, results in worsened cardiovascular outcomes in diabetes. We have established that the mesenteric circulation in Type

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::480bcfabe27f4c1b9c3568668fbe3498
https://doi.org/10.1152/ajpheart.91487.2007

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Abstract 427: Mammalian Target of Rapamycin (mTOR) Inhibition Attenuates Angiotensin II-Induced Hypertension and Endothelial Dysfunction

Autor: Sean P Didion, Joel A Sarmiento, Erin M Mezzetti

Publikováno v: Hypertension. 60

Angiotensin (Ang) II produces hypertension, endothelial dysfunction as well as vascular hypertrophy. mTOR is a key regulator of cell growth and protein synthesis, however the contribution of mTOR to hypertension and endothelial dysfunction produced b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d7805a5c27149f5633e3032970f48cb9
https://doi.org/10.1161/hyp.60.suppl_1.a427

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Neurovascular injury in acute hyperglycemia and diabetes: A comparative analysis in experimental stroke

Autor: Susan C. Fagan, Maribeth H. Johnson, Mostafa M. Elgebaly, Erin M. Mezzetti, Askiel Bruno, Roshini Prakash, Weiguo Li, Adviye Ergul, Safia Ogbi

Admission hyperglycemia impacts ischemic stroke deleteriously but the relative role of acute hyperglycemia (HG) versus diabetes in the pathogenesis of this poor outcome is not clear.To determine the effect of acute HG on neurovascular outcomes of str

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa8f918537e788b40cd7bed92cc9d54c
https://europepmc.org/articles/PMC3169178/

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Endothelin-1-mediated cerebrovascular remodeling is not associated with increased ischemic brain injury in diabetes

Autor: Weiguo, Li, Aisha I, Kelly-Cobbs, Erin M, Mezzetti, Susan C, Fagan, Adviye, Ergul

Publikováno v: Canadian journal of physiology and pharmacology. 88(8)

Diabetes increases the risk of as well as poor outcome after stroke. Matrix metalloprotease (MMP) activation disrupts blood-brain barrier integrity after cerebral ischemia. We have previously shown that type 2 diabetes promotes remodeling of middle c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9984ec1045e5c73b6ae8acad96c57f2b
https://pubmed.ncbi.nlm.nih.gov/20725136

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Vascular protection in diabetic stroke: role of matrix metalloprotease-dependent vascular remodeling

Autor: Weiguo Li, Adviye Ergul, Erin M. Mezzetti, Mostafa M. Elgebaly, Maribeth H. Johnson, Safia Ogbi, Susan C. Fagan, Roshini Prakash

Temporary focal ischemia causes greater hemorrhagic transformation (HT) in diabetic Goto-Kakizaki (GK) rats, a model with increased cerebrovascular matrix metalloprotease (MMP) activity and tortuosity. The objective of the current study was to test t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79e9dc95f74320999686e8b1d41aeb2a
https://europepmc.org/articles/PMC3002883/

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