Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Erin L. Braybrooke"'
Autor:
Thomas G. Hayhow, Beth Williamson, Mandy Lawson, Natalie Cureton, Erin L. Braybrooke, Andrew Campbell, Rodrigo J. Carbajo, Azadeh Cheraghchi-Bashi, Elisabetta Chiarparin, Coura R. Diène, Charlene Fallan, David I. Fisher, Frederick W. Goldberg, Lorna Hopcroft, Philip Hopcroft, Anne Jackson, Jason G. Kettle, Teresa Klinowska, Ulrike Künzel, Gillian Lamont, Hilary J. Lewis, Gareth Maglennon, Scott Martin, Pablo Morentin Gutierrez, Christopher J. Morrow, Myria Nikolaou, J. Willem M. Nissink, Patrick O’Shea, Radoslaw Polanski, Markus Schade, James S. Scott, Aaron Smith, Judith Weber, Joanne Wilson, Bin Yang, Claire Crafter
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-17 (2024)
Abstract Targeting the estrogen receptor alpha (ERα) pathway is validated in the clinic as an effective means to treat ER+ breast cancers. Here we present the development of a VHL-targeting and orally bioavailable proteolysis-targeting chimera (PROT
Externí odkaz:
https://doaj.org/article/ec006f9560824ea494be6041bb1eeb60
Autor:
Iain A. Cumming, Sébastien L. Degorce, Anna Aagaard, Erin L. Braybrooke, Nichola L. Davies, Coura R. Diène, Andrew J. Eatherton, Hannah R. Felstead, Sam D. Groombridge, Eva M. Lenz, Yunxia Li, Youfeng Nai, Stuart Pearson, Graeme R. Robb, James S. Scott, Oliver R. Steward, Chengyan Wu, Yafeng Xue, Lanping Zhang, Yanxiu Zhang
Publikováno v:
Bioorganicmedicinal chemistry. 63
In this article, we report the discovery of a series of pyrimidopyridones as inhibitors of IRAK4 kinase. From a previously disclosed 5-azaquinazoline series, we found that switching the pyridine ring for an N-substituted pyridone gave a novel hinge b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24a392e9908e5c3f41f7d9cc5004c347
https://pubmed.ncbi.nlm.nih.gov/35439688
https://pubmed.ncbi.nlm.nih.gov/35439688
Autor:
Hayhow, Thomas G.1 (AUTHOR) thomas.hayhow@astrazeneca.com, Williamson, Beth1 (AUTHOR), Lawson, Mandy1 (AUTHOR), Cureton, Natalie1 (AUTHOR), Braybrooke, Erin L.1 (AUTHOR), Campbell, Andrew2 (AUTHOR), Carbajo, Rodrigo J.1 (AUTHOR), Cheraghchi-Bashi, Azadeh1 (AUTHOR), Chiarparin, Elisabetta1 (AUTHOR), Diène, Coura R.1 (AUTHOR), Fallan, Charlene1 (AUTHOR), Fisher, David I.3 (AUTHOR), Goldberg, Frederick W.1 (AUTHOR), Hopcroft, Lorna1 (AUTHOR), Hopcroft, Philip3 (AUTHOR), Jackson, Anne3 (AUTHOR), Kettle, Jason G.1 (AUTHOR), Klinowska, Teresa1 (AUTHOR), Künzel, Ulrike3 (AUTHOR), Lamont, Gillian1 (AUTHOR)
Publikováno v:
Communications Biology. 5/13/2024, Vol. 7 Issue 1, p1-17. 17p.