Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Erin K. Schrader"'
Autor:
Eitan Israeli, Ashwini Patil, Andreas T Matouschek, Kenta Nakai, Erin K. Schrader, Tomonao Inobe, Daniel A. Kraut, Dhaval Nanavati
Publikováno v:
ACS Chemical Biology. 7:1444-1453
The proteasome is the degradation machine at the center of the ubiquitin-proteasome system and controls the concentrations of many proteins in eukaryotes. It is highly processive so that substrates are degraded completely into small peptides, avoidin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ad302fed2679f580fd626bbbf36149d
https://doi.org/10.1021/cb3001155
https://doi.org/10.1021/cb3001155
Publikováno v:
Journal of Biological Chemistry. 286:39051-39058
The Gli proteins are the transcriptional effectors of the mammalian Hedgehog signaling pathway. In an unusual mechanism, the proteasome partially degrades or processes Gli3 in the absence of Hedgehog pathway stimulation to create a Gli3 fragment that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac83bbfa6829622ce4d9a9be8a2e0f94
https://doi.org/10.1074/jbc.m111.274993
https://doi.org/10.1074/jbc.m111.274993
Publikováno v:
Nature Chemical Biology. 5:815-822
Protein degradation plays a central role in many cellular functions. Misfolded and damaged proteins are removed from the cell to avoid toxicity. The concentrations of regulatory proteins are adjusted by degradation at the appropriate time. Both forei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d916524cb0d1c7981ef2285bcbdc2622
https://doi.org/10.1038/nchembio.250
https://doi.org/10.1038/nchembio.250
Publikováno v:
Chemistry & Biology. 17:917-918
The ability to induce degradation of a protein of interest is a powerful experimental tool used to ascertain protein function. Iwamoto et al. (2010) describe a method that allows reversible and dose-dependent modulation of the stability of any target
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ddc34451dcea6bde267ff179ceef3c9
https://doi.org/10.1016/j.chembiol.2010.09.004
https://doi.org/10.1016/j.chembiol.2010.09.004
Publikováno v:
Nature Chemical Biology. 5:954-954
Nat. Chem. Biol. 5, 815–822 (2009); published online 19 October 2009; corrected after print 28 October 2009 In the version of this article initially published, a positive competing financial interest statement was noted, where none exists. The erro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::82970545e1fb757ca91e824f7f30d4b7
https://doi.org/10.1038/nchembio1209-954c
https://doi.org/10.1038/nchembio1209-954c