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of 3
pro vyhledávání: '"Erin K. Sanabria"'
Autor:
Samuel A. Barnes, Andrew J. Grottick, David L MacQueen, Jared W. Young, Erin K. Sanabria, Chris Carroll, Vishal Bobba
Publikováno v:
Psychopharmacology. 238:979-990
Cognitive function is closely linked to functional outcomes in psychiatric disorders such as schizophrenia, however developing effective treatments for cognitive dysfunction have proven elusive. Potential reasons for this may include the complexity o
Autor:
Dominic P. Behan, Kevin Whelan, Michael Morgan, Erin K. Sanabria, Andrew J. Grottick, Carleton R. Sage
Publikováno v:
Psychopharmacology
Rationale Synergistic or supra-additive interactions between the anorectics (dex)fenfluramine and phentermine have been reported previously in the rat and in the clinic. Studies with 5-HT2C antagonists and 5-HT2C knockouts have demonstrated dexfenflu
Autor:
Marc Decaire, Graeme Semple, Yifeng Xiong, Andrew J. Grottick, Woo H. Yoon, Kevin Whelan, Sonja Strah-Pleynet, Martin C. Cherrier, Brett Ullman, John Frazer, Hussien A. Al-Shamma, Jin-Sun Karoline Choi, Konrad Feichtinger, Erin K. Sanabria
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:1870-1873
A series of fused bicyclic heterocycles was identified as potent and selective 5-HT 2A receptor antagonists. Optimization of the series resulted in compounds that had improved PK properties, favorable CNS partitioning, good pharmacokinetic properties