Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Erin K. Linehan"'
Autor:
Carol E. Schrader, Travis Williams, Klaus Pechhold, Erin K. Linehan, Daisuke Tsuchimoto, Yusaku Nakabeppu
Publikováno v:
The Journal of Immunology. 210:1804-1814
Somatic hypermutation (SHM) is necessary for Ab diversification and involves error-prone DNA repair of activation-induced cytidine deaminase–induced lesions in germinal center (GC) B cells but can also cause genomic instability. GC B cells express
Publikováno v:
PLoS Genetics, Vol 11, Iss 8, p e1005438 (2015)
Activation-induced cytidine deaminase (AID) is required for initiation of Ig class switch recombination (CSR) and somatic hypermutation (SHM) of antibody genes during immune responses. AID has also been shown to induce chromosomal translocations, mut
Externí odkaz:
https://doaj.org/article/1ba46d83f23443f490a3690fd7e007c6
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0134397 (2015)
Activation-induced cytidine deaminase (AID) is essential for class switch recombination (CSR) and somatic hypermutation (SHM) of Ig genes. The C terminus of AID is required for CSR but not for SHM, but the reason for this is not entirely clear. By re
Externí odkaz:
https://doaj.org/article/b3b52a4123334ca890d600c22d39781d
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e36061 (2012)
During activation of B cells to undergo class switching, B cell metabolism is increased, and levels of reactive oxygen species (ROS) are increased. ROS can oxidize DNA bases resulting in substrates for the DNA glycosylases Ogg1 and Nth1. Ogg1 and Nth
Externí odkaz:
https://doaj.org/article/33c12d8efe1b4d5ebcaa67e2fcb34fc9
Autor:
Jeroen E. J. Guikema, Daisuke Tsuchimoto, Nada Esa, Yusaku Nakabeppu, Robert T. Woodland, Erin K. Linehan, Carol E. Schrader
Publikováno v:
Journal of immunology (Baltimore, Md., 193(2), 931-939. American Association of Immunologists
Activation-induced cytidine deaminase (AID) initiates a process generating DNA mutations and breaks in germinal center (GC) B cells that are necessary for somatic hypermutation and class-switch recombination. GC B cells can “tolerate” DNA damage
Autor:
Daisuke Tsuchimoto, Mikayla R. Thompson, Tatenda Kadungure, Ghaith Habboub, Carol E. Schrader, Yusaku Nakabeppu, Janet Stavnezer, Anna J. Ucher, Erin K. Linehan
Publikováno v:
Proceedings of the National Academy of Sciences. 111:9217-9222
Somatic hypermutation (SHM) of antibody variable region genes is initiated in germinal center B cells during an immune response by activation-induced cytidine deaminase (AID), which converts cytosines to uracils. During accurate repair in nonmutating
Autor:
Janet Stavnezer, Erin K. Linehan, Jeroen E. J. Guikema, Zhenkun Lou, Lyne Khair, Colin Ogilvie, Carol E. Schrader, Niek G. J. Leus, Anna J. Ucher
Publikováno v:
The Journal of Immunology, 192(10), 4887-4896. AMER ASSOC IMMUNOLOGISTS
Journal of immunology (Baltimore, Md., 192(10), 4887-4896. American Association of Immunologists
Journal of immunology (Baltimore, Md., 192(10), 4887-4896. American Association of Immunologists
Activation-induced cytidine deaminase (AID) initiates Ab class-switch recombination (CSR) in activated B cells resulting in exchanging the IgH C region and improved Ab effector function. During CSR, AID instigates DNA double-strand break (DSB) format
Publikováno v:
DNA Repair. 12:1087-1093
During somatic hypermutation (SHM) of antibody variable (V) region genes, activation-induced cytidine deaminase (AID) converts dC to dU, and dUs can either be excised by uracil DNA glycosylase (UNG), by mismatch repair, or replicated over. If UNG exc
Autor:
Erin K. Linehan, Janet Stavnezer, Sanjay Ranjit, Anna J. Ucher, Carol E. Schrader, Lyne Khair, Mrinmay Chakrabarti
Publikováno v:
The Journal of Immunology. 187:2464-2475
Activation-induced cytidine deaminase (AID) is induced in B cells during an immune response and is essential for both class-switch recombination (CSR) and somatic hypermutation of Ab genes. The C-terminal 10 aa of AID are required for CSR but not for
Autor:
Jeroen E. J. Guikema, Erin K. Cloherty, Rachel M. Gerstein, Eric Evan-Browning, Daisuke Tsuchimoto, Carol E. Schrader, Yusaku Nakabeppu, Erin K. Linehan
Publikováno v:
Journal of immunology (Baltimore, Md., 186(4), 1943-1950. American Association of Immunologists
B cell development involves rapid cellular proliferation, gene rearrangements, selection, and differentiation, and it provides a powerful model to study DNA repair processes in vivo. Analysis of the contribution of the base excision repair pathway in