The INO80 chromatin remodeler sustains metabolic stability by promoting TOR signaling and regulating histone acetylation.

Autor: Sean L Beckwith, Erin K Schwartz, Pablo E García-Nieto, Devin A King, Graeme J Gowans, Ka Man Wong, Tessa L Eckley, Alexander P Paraschuk, Egan L Peltan, Laura R Lee, Wei Yao, Ashby J Morrison

Publikováno v: PLoS Genetics, Vol 14, Iss 2, p e1007216 (2018)

Chromatin remodeling complexes are essential for gene expression programs that coordinate cell function with metabolic status. However, how these remodelers are integrated in metabolic stability pathways is not well known. Here, we report an expansiv

Externí odkaz: https://doaj.org/article/a4cf6eb375c248adad872857fdf2a0b6

Saccharomyces cerevisiae Mus81-Mms4 prevents accelerated senescence in telomerase-deficient cells

Autor: Wolf Dietrich Heyer, Aurèle Piazza, Becky Xu Hua Fu, Kevin Yan, Shih-Hsun Hung, Erin K. Schwartz, Damon L. Meyer

Publikováno v: PLoS Genetics
PLoS Genetics, 2020, 16 (5), pp.e1008816. ⟨10.1371/journal.pgen.1008816⟩
PLoS Genetics, Public Library of Science, 2020, 16 (5), pp.e1008816. ⟨10.1371/journal.pgen.1008816⟩
PLoS genetics, vol 16, iss 5
PLoS Genetics, Vol 16, Iss 5, p e1008816 (2020)

Alternative lengthening of telomeres (ALT) in human cells is a conserved process that is often activated in telomerase-deficient human cancers. This process exploits components of the recombination machinery to extend telomere ends, thus allowing for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1f909d83245fa22ed8072eaf0fa8330
https://hal.science/hal-02999779

Carcinogen susceptibility is regulated by genome architecture and predicts cancer mutagenesis

Autor: Ashby J. Morrison, Devin A. King, Rafael E. Herrera, Philippe Collas, Jonas Paulsen, Pablo E. García-Nieto, Erin K. Schwartz

Publikováno v: The EMBO Journal. 36:2829-2843

The development of many sporadic cancers is directly initiated by carcinogen exposure. Carcinogens induce malignancies by creating DNA lesions (i.e., adducts) that can result in mutations if left unrepaired. Despite this knowledge, there has been rem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06ef96d09f73be9da8a449d06201f56a
https://doi.org/10.15252/embj.201796717

Correction for Muñoz-Galván et al., 'Distinct Roles of Mus81, Yen1, Slx1-Slx4, and Rad1 Nucleases in the Repair of Replication-Born Double-Strand Breaks by Sister Chromatid Exchange'

Autor: Wolf Dietrich Heyer, Cristina Tous, Stephen C. West, Kirk T. Ehmsen, Andrés Aguilera, Miguel G. Blanco, Erin K. Schwartz, Sandra Muñoz-Galván

Publikováno v: Molecular and cellular biology. 37(11)

Most spontaneous DNA double-strand breaks (DSBs) arise during replication and are repaired by homologous recombination (HR) with the sister chromatid. Many proteins participate in HR, but it is often difficult to determine their in vivo functions due

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c5229aeb66607cf50f1bd95668b3fc4
https://pubmed.ncbi.nlm.nih.gov/22354996

Processing of joint molecule intermediates by structure-selective endonucleases during homologous recombination in eukaryotes

Autor: Erin K. Schwartz, Wolf Dietrich Heyer

Publikováno v: Chromosoma
Chromosoma, vol 120, iss 2

Homologous recombination is required for maintaining genomic integrity by functioning in high-fidelity repair of DNA double-strand breaks and other complex lesions, replication fork support, and meiotic chromosome segregation. Joint DNA molecules are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cf868a8df0566858d4960894bdb2493
https://pubmed.ncbi.nlm.nih.gov/21369956