Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Erin J. Van Schaik"'
Autor:
Mohammed Eslami, Yi-Pei Chen, Ainsley C. Nicholson, Mark Weston, Melissa Bell, John R. McQuiston, James Samuel, Erin J. van Schaik, Paul de Figueiredo
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Limited data significantly hinders our capability of biothreat assessment of novel bacterial strains. Integration of data from additional sources that can provide context about the strain can address this challenge. Datasets from different s
Externí odkaz:
https://doaj.org/article/ff6eee75b26244d2a7b2a958baf58900
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)
The long non-coding RNAs (lncRNAs) are evolutionarily conserved classes of non-coding regulatory transcripts of > 200 nucleotides in length. They modulate several transcriptional and post-transcriptional events in the organism. Depending on their cel
Externí odkaz:
https://doaj.org/article/f49572fbd86e4b34bdf00f67c3a2b5f8
Autor:
Elizabeth Di Russo Case, Saugata Mahapatra, Caitlyn T. Hoffpauir, Kranti Konganti, Andrew E. Hillhouse, James E. Samuel, Erin J. Van Schaik
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 4 (2022)
ABSTRACT Coxiella burnetii requires a type IVB secretion system (T4SS) to promote intracellular replication and virulence. We hypothesized that Coxiella employs its T4SS to secrete effectors that enable stealthy colonization of immune cells. To addre
Externí odkaz:
https://doaj.org/article/6ee2347089ea4afcb5f94b7ebd9c813d
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Coxiella burnetii is an obligate intracellular bacterium which, in humans, causes the disease Q fever. Although Q fever is most often a mild, self-limiting respiratory disease, it can cause a range of severe syndromes including hepatitis, myocarditis
Externí odkaz:
https://doaj.org/article/4562c23f252345a9abf593ae7c5048b4
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Q-VAX®, a whole cell, formalin-inactivated vaccine, is the only vaccine licensed for human use to protect against Coxiella burnetii, the cause of Q fever. Although this vaccine provides long-term protection, local and systemic reactogenic responses
Externí odkaz:
https://doaj.org/article/8c89b6b94284451e9282da3c60746f3a
Autor:
Jing Yang, Mohammed Eslami, Yi-Pei Chen, Mayukh Das, Dongmei Zhang, Shaorong Chen, Alexandria-Jade Roberts, Mark Weston, Angelina Volkova, Kasra Faghihi, Robbie K. Moore, Robert C. Alaniz, Alice R. Wattam, Allan Dickerman, Clark Cucinell, Jarred Kendziorski, Sean Coburn, Holly Paterson, Osahon Obanor, Jason Maples, Stephanie Servetas, Jennifer Dootz, Qing-Ming Qin, James E. Samuel, Arum Han, Erin J. van Schaik, Paul de Figueiredo
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Bacterial pathogen identification, which is critical for human health, has historically relied on culturing organisms from clinical specimens. More recently, the application of machine learning (ML) to whole-genome sequences (WGSs) has facilitated pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::014132f636172c039bf5545eaa2c010f
https://doi.org/10.1073/pnas.2112886119
https://doi.org/10.1073/pnas.2112886119
Autor:
Yong Zhang, Jiaqi Fu, Shuxin Liu, Lidong Wang, Jiazhang Qiu, Erin J. van Schaik, James E. Samuel, Lei Song, Zhao-Qing Luo
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Many effectors of the Coxiella burnetii Dot/Icm transporter are important for its virulence, but the lack of understanding of their biochemical activity prevents the use of them as potential therapeutic targets. Here, we found that the e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::735db6e4b757cfc4465d39e0e55b665c
https://doi.org/10.1073/pnas.2110877119
https://doi.org/10.1073/pnas.2110877119
Autor:
Anthony E. Gregory, Erin J. van Schaik, Alycia P. Fratzke, Kasi E. Russell-Lodrigue, Christina M. Farris, James E. Samuel
Publikováno v:
Cell Reports Medicine
Summary Q fever is caused by the intracellular bacterium Coxiella burnetii, for which there is no approved vaccine in the United States. A formalin-inactivated whole-cell vaccine (WCV) from virulent C. burnetii NMI provides single-dose long-lived pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be8ef4056f0b2424f4011a2dc2c09078
http://europepmc.org/articles/PMC8714860
http://europepmc.org/articles/PMC8714860
Autor:
Robert Faris, Phillip L. Felgner, James E. Samuel, Adam Vigil, Erin J. van Schaik, Anthony E. Gregory, Chen Chen, Laura R. Hendrix
Publikováno v:
J Infect Dis
Background Protective immunity against Coxiella burnetii infection is conferred by vaccination with virulent (PI-WCV), but not avirulent (PII-WCV) whole-cell inactivated bacterium. The only well-characterized antigenic difference between virulent and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f92f5d83bbcd6023eecc38d0de6d114
https://doi.org/10.1093/infdis/jiz146
https://doi.org/10.1093/infdis/jiz146
Autor:
Omar H. Khalaf, Anthony E. Gregory, Erin J. van Schaik, Lauren W. Stranahan, Sankar P. Chaki, Daniel G. Garcia-Gonzalez, Angela M. Arenas-Gamboa, Martha E. Hensel, James E. Samuel
Publikováno v:
Infect Immun
Reproductive failure is the hallmark of brucellosis in animals. An uncommon but important complication in pregnant women who become acutely infected with Brucella melitensis is spontaneous pregnancy loss or vertical transmission to the fetus. Unfortu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59cab92ea01eb054d16740cdc6fbc11e
https://doi.org/10.1128/iai.00204-20
https://doi.org/10.1128/iai.00204-20