Výsledky vyhledávání - "Erin J. Terpstra"

Akademický článek

Mifepristone increases mRNA translation rate, triggers the unfolded protein response, increases autophagic flux, and kills ovarian cancer cells in combination with proteasome or lysosome inhibitors

Autor: Lei Zhang, Maria B. Hapon, Alicia A. Goyeneche, Rekha Srinivasan, Carlos D. Gamarra-Luques, Eduardo A. Callegari, Donis D. Drappeau, Erin J. Terpstra, Bo Pan, Jennifer R. Knapp, Jeremy Chien, Xuejun Wang, Kathleen M. Eyster, Carlos M. Telleria

Publikováno v: Molecular Oncology, Vol 10, Iss 7, Pp 1099-1117 (2016)

The synthetic steroid mifepristone blocks the growth of ovarian cancer cells, yet the mechanism driving such effect is not entirely understood. Unbiased genomic and proteomic screenings using ovarian cancer cell lines of different genetic backgrounds

Externí odkaz: https://doaj.org/article/dd087c8833bd49a0b6248a9faae346ec

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Dysregulation and Diagnostic Potential of microRNA in Alzheimer’s Disease

Autor: Yigang Tong, Ruizhu Liu, Fangfang Qiao, Bo Pan, Yanqing Wang, Erin J Terpstra, Jin Wang, Yaoqian Pan

Publikováno v: Journal of Alzheimer's Disease. 49:1-12

Alzheimer’s disease (AD) is one of the most common neurodegenerative diseases and is considered to be the main cause of cognitive impairment in elderly people. The major symptom of AD is progressive dementia that eventually results in dysfunction o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5434c95662c96103d93a3aab40f1e48
https://doi.org/10.3233/jad-150451

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Mifepristone increases mRNA translation rate, triggers the unfolded protein response, increases autophagic flux, and kills ovarian cancer cells in combination with proteasome or lysosome inhibitors

Autor: Carlos D. Gamarra-Luques, Carlos M. Telleria, Jeremy Chien, Erin J Terpstra, Bo Pan, Alicia A. Goyeneche, Jennifer R. Knapp, Eduardo Callegari, Kathleen M. Eyster, Rekha Srinivasan, Donis D. Drappeau, Lei Zhang, Xuejun Wang, María Belén Hapon

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3af27e9aec7d6844f0c4b11af4cf2d0c
Wiley Online Library

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Abstract 422: Activation of the p38 Branch of Mitogen Activated Protein Kinase Pathway Stimulates Proteasome Proteolytic Function

Autor: Xuejun Wang, Changhua Wang, Erin J Terpstra, Yibin Wang, Xuejun 'XJ' Wang

Publikováno v: Circulation Research. 117

Ubiquitin-proteasome system (UPS) dysfunction is associated with development of most heart diseases. Proteasomal functional insufficiency has been experimentally demonstrated to play an important role in cardiac pathogenesis. Hence, enhancing proteas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b74bd1e9967657b9bff926d379b85930
https://doi.org/10.1161/res.117.suppl_1.422

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Abstract 423: Proteasome Priming by Protein Kinase G Protects Against Myocardial Ischemia-reperfusion Injury

Autor: Xuejun Wang, Erin J Terpstra, Eduardo Callegari, Chengjun Hu, Hanming Zhang, Xuejun \\'XJ\\' Wang

Publikováno v: Circulation Research. 117

Cardiac proteasome functional insufficiency is implicated in a large subset of heart disease and has been experimentally demonstrated to play an essential role in cardiac proteotoxicity, including desmin-related cardiomyopathy and myocardial ischemia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ac225a7d427606ab885d9a6f5ce6cb27
https://doi.org/10.1161/res.117.suppl_1.423

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Protein kinase g positively regulates proteasome-mediated degradation of misfolded proteins

Autor: Xuejun Wang, Mark J. Ranek, Jie Li, Erin J Terpstra, David A. Kass

Publikováno v: Circulation. 128(4)

Background— Proteasome functional insufficiency is implicated in a large subset of cardiovascular diseases and may play an important role in their pathogenesis. The regulation of proteasome function is poorly understood, hindering the development o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6a9b0a2da9611f58a1fc639505982b7
https://pubmed.ncbi.nlm.nih.gov/23770743

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Ubiquitin receptors and protein quality control

Autor: Xuejun Wang, Erin J Terpstra

Publikováno v: Journal of molecular and cellular cardiology. 55

Protein quality control (PQC) is essential to intracellular proteostasis and is carried out by sophisticated collaboration between molecular chaperones and targeted protein degradation. The latter is performed by proteasome-mediated degradation, chap

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6252b2c92e2a2237979ce38b2fa208e3
https://pubmed.ncbi.nlm.nih.gov/23046644

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