Výsledky vyhledávání - "Erin J. Easlon"

Akademický článek

Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cells.

Autor: Laura Bordone, Maria Carla Motta, Frederic Picard, Ashley Robinson, Ulupi S Jhala, Javier Apfeld, Thomas McDonagh, Madeleine Lemieux, Michael McBurney, Akos Szilvasi, Erin J Easlon, Su-Ju Lin, Leonard Guarente

Publikováno v: PLoS Biology, Vol 4, Iss 2, p e31 (2006)

Sir2 and insulin/IGF-1 are the major pathways that impinge upon aging in lower organisms. In Caenorhabditis elegans a possible genetic link between Sir2 and the insulin/IGF-1 pathway has been reported. Here we investigate such a link in mammals. We s

Externí odkaz: https://doaj.org/article/4f48d2d275da44578e958920dcf5b1e2

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The Effects of Practice-Based Training on Graduate Teaching Assistants' Classroom Practices

Autor: Christopher Pagliarulo, Jensen M. Spear, Erin A. Becker, Mitchell Singer, Michele M. Igo, Alberto Guzman-Alvarez, Marc T. Facciotti, Erin J. Easlon, Sarah C. Potter

Publikováno v: CBE life sciences education, vol 16, iss 4
CBE Life Sciences Education
Becker, EA; Easlon, EJ; Potter, SC; Guzman-Alvarez, A; Spear, JM; Facciotti, MT; et al.(2017). The effects of practice-based training on graduate teaching assistants’ classroom practices. CBE Life Sciences Education, 16(4). doi: 10.1187/cbe.16-05-0162. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/8mp0x597

This article describes implementation of a practice-based graduate teaching assistant (GTA)-training program. GTA implementation of evidence-based teaching practices is measured across 160 hours of videotaped classroom instruction, and longitudinal c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25a49c113e297513bde32209f94c96a3
https://escholarship.org/uc/item/8mp0x597

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Identification of Potential Calorie Restriction-Mimicking Yeast Mutants with Increased Mitochondrial Respiratory Chain and Nitric Oxide Levels

Autor: Michiko Kato, Shu Ping Lu, Li Xie, Felicia Tsang, Pablo R. Castello, Robert O. Poyton, Su Ju Lin, Erin J. Easlon, Bin Li, Craig Skinner, Tianlin Li, Chen Wang

Publikováno v: Journal of Aging Research, Vol 2011 (2011)
Journal of Aging Research

Calorie restriction (CR) induces a metabolic shift towards mitochondrial respiration; however, molecular mechanisms underlying CR remain unclear. Recent studies suggest that CR-induced mitochondrial activity is associated with nitric oxide (NO) produ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0496ad436beb579c98feca52bc9cac61
https://doi.org/10.4061/2011/673185

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Deleting the 14-3-3 Protein Bmh1 Extends Life Span in Saccharomyces cerevisiae by Increasing Stress Response

Autor: Su Ju Lin, Chen Wang, Craig Skinner, Erin J. Easlon

Publikováno v: Genetics. 183:1373-1384

Enhanced stress response has been suggested to promote longevity in many species. Calorie restriction (CR) and conserved nutrient-sensing target of rapamycin (TOR) and protein kinase A (PKA) pathways have also been suggested to extend life span by in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9552aac44493270d806f91e2509aefae
https://doi.org/10.1534/genetics.109.107797

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The malate–aspartate NADH shuttle components are novel metabolic longevity regulators required for calorie restriction-mediated life span extension in yeast

Autor: Felicia Tsang, Chen Wang, Erin J. Easlon, Craig Skinner, Su Ju Lin

Publikováno v: Genes & Development. 22:931-944

Recent studies suggest that increased mitochondrial metabolism and the concomitant decrease in NADH levels mediate calorie restriction (CR)-induced life span extension. The mitochondrial inner membrane is impermeable to NAD (nicotinamide adenine dinu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::378bb72e80006091715d952c77673b86
https://doi.org/10.1101/gad.1648308

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Correction: Sirt1 Regulates Insulin Secretion by Repressing UCP2 in Pancreatic β Cells

Autor: Thomas McDonagh, Frederic Picard, Javier Apfeld, Michael W. McBurney, Maria Carla Motta, Akos Szilvasi, Laura Bordone, Madeleine E. Lemieux, Leonard Guarente, Su Ju Lin, Erin J. Easlon, Ulupi S. Jhala, Ashley Robinson

Publikováno v: PLoS Biology, Vol 13, Iss 12, p e1002346 (2015)

The authors would like to clarify that the controls previously depicted in Figs Figs4E4E and and7A7A were for different experiments and were included in error. Fig 4 UCP2 is Up-Regulated in Sirt1 Knockdown Cells and in Sirt1 KO Mice. Fig 7 UCP2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::240b9fcf96a99b861555c632f43a039f
http://europepmc.org/articles/PMC4694709?pdf=render

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Tissue-specific regulation of SIRT1 by calorie restriction

Autor: Erin J. Easlon, Su Ju Lin, Hwei Ling Cheng, Danica Chen, Frederick W. Alt, Joanne Bruno, Leonard Guarente

Publikováno v: Genesdevelopment. 22(13)

Calorie restriction (CR) has been reported to increase SIRT1 protein levels in mice, rats, and humans, and elevated activity of SIRT1 orthologs extends life span in yeast, worms, and flies. In this study, we challenge the paradigm that CR induces SIR

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca448ca68fd2447aa7117de5ba8c96b5
https://pubmed.ncbi.nlm.nih.gov/18550784

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