Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Erin J. Cram"'
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
IntroductionCells generate mechanical forces mainly through myosin motor activity on the actin cytoskeleton. In C. elegans, actomyosin stress fibers drive contractility of the smooth muscle-like cells of the spermatheca, a distensible, tube-shaped ti
Externí odkaz:
https://doaj.org/article/3418ec5cb9b844219297db54102fbd9a
Publikováno v:
Life, Vol 12, Iss 11, p 1878 (2022)
Protein kinase A (PKA), which regulates a diverse set of biological functions downstream of cyclic AMP (cAMP), is a tetramer consisting of two catalytic subunits (PKA-C) and two regulatory subunits (PKA-R). When cAMP binds the PKA-R subunits, the PKA
Externí odkaz:
https://doaj.org/article/2b14df5a5de942bd9b1f3909945301d3
Autor:
Samuel Mortensen, Jessica D. Weaver, Suphinya Sathitloetsakun, Lauren F. Cole, Noreen F. Rizvi, Erin J. Cram, Carolyn W. T. Lee‐Parsons
Publikováno v:
Plant Direct, Vol 3, Iss 12, Pp n/a-n/a (2019)
Abstract Cys2/His2‐type (C2H2) zinc finger proteins, such as ZCT1, are an important class of transcription factors involved in growth, development, and stress responses in plants. In the medicinal plant Catharanthus roseus, the zinc finger Catharan
Externí odkaz:
https://doaj.org/article/cb3616108f6e48d6888d390dc1051112
Autor:
Samuel Mortensen, Diana Bernal-Franco, Lauren F. Cole, Suphinya Sathitloetsakun, Erin J. Cram, Carolyn W. T. Lee-Parsons
Publikováno v:
Frontiers in Plant Science, Vol 10 (2019)
The Catharanthus roseus plant is the exclusive source of the valuable anticancer terpenoid indole alkaloids, vinblastine (VB) and vincristine (VC). The recent availability of transcriptome and genome resources for C. roseus necessitates a fast and re
Externí odkaz:
https://doaj.org/article/4d546bbe020c4c9c948997f147cbc71d
Autor:
Xiaofei Bai, Jeff Bouffard, Avery Lord, Katherine Brugman, Paul W Sternberg, Erin J Cram, Andy Golden
Publikováno v:
eLife, Vol 9 (2020)
PIEZO1 and PIEZO2 are newly identified mechanosensitive ion channels that exhibit a preference for calcium in response to mechanical stimuli. In this study, we discovered the vital roles of pezo-1, the sole PIEZO ortholog in Caenorhabditiselegans, in
Externí odkaz:
https://doaj.org/article/e671d427fd1c425d9185ef7da72a7e0d
Autor:
Erin J. Cram
Publikováno v:
Current biology : CB. 32(19)
How does tissue elongation occur? A recent paper identifies a new mechanism: elongation of the Caenorhabditis elegans hermaphrodite gonad is driven by pressure from proliferating germ cells confined within a tube. The distal tip cell, which caps the
Autor:
Samuel, Mortensen, Lauren F, Cole, Diana, Bernal-Franco, Suphinya, Sathitloetsakun, Erin J, Cram, Carolyn W T, Lee-Parsons
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2505
Catharanthus roseus produces medicinal terpenoid indole alkaloids, including the critical anti-cancer compounds vinblastine and vincristine in its leaves. Recently, we developed a highly efficient transient expression method relying on Agrobacterium-
Autor:
Shiri Avivi Kela, Kriti Sethi, Pei Yi Tan, Danesha Suresh, Hui Ting Ong, Perla G. Castaneda, Mustafi R. Amin, Tal Laviv, Erin J. Cram, Jan Faix, Ronen Zaidel-Bar
Publikováno v:
The Journal of cell biology. 222(2)
Contractile epithelial tubes are found in various organs, such as lung airways and blood capillaries. Their ability to sense luminal pressure and respond with adequate contractility is essential for their physiology, and its mis-regulation results in
Autor:
Olivia Triplett, Kristopher Burkewitz, Charlotte A. Kelley, William B. Mair, Erin J. Cram, Samyukta Mallick
Publikováno v:
Cytoskeleton (Hoboken)
Actomyosin networks are organized in space, direction, size, and connectivity to produce coordinated contractions across cells. We use the C. elegans spermatheca, a tube composed of contractile myoepithelial cells, to study how actomyosin structures
Publikováno v:
Molecular Biology of the Cell
Actomyosin-based contractility in smooth muscle and nonmuscle cells is regulated by signaling through the small GTPase Rho and by calcium-activated pathways. We use the myoepithelial cells of the Caenorhabditis elegans spermatheca to study the mechan