Predictive Biomarkers of Gastroesophageal Reflux Disease and Barrett’s Esophagus in World Trade Center Exposed Firefighters: a 15 Year Longitudinal Study

Autor: Syed H. Haider, Sophia Kwon, Rachel Lam, Audrey K. Lee, Erin J. Caraher, George Crowley, Liqun Zhang, Theresa M. Schwartz, Rachel Zeig-Owens, Mengling Liu, David J. Prezant, Anna Nolan

Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-7 (2018)

Abstract Gastroesophageal reflux disease (GERD) and Barrett’s Esophagus (BE), which are prevalent in the World Trade Center (WTC) exposed and general populations, negatively impact quality of life and cost of healthcare. GERD, a risk factor of BE,

Externí odkaz: https://doaj.org/article/add5c302a0b84773bf330592a32303b5

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Autor: Syed Hissam Haider, Liqun Zhang, George Crowley, Erin J. Caraher, Rachel Lam, Sophia Kwon, Ann Marie Schmidt, Lung-Chi Chen, D. J. Prezant, Anna Nolan

Publikováno v: Journal of Clinical and Translational Science, Vol 1, Pp 7-8 (2017)

OBJECTIVES/SPECIFIC AIMS: Obstructive lung disease following particulate matter (PM) exposure is a major health concern. Coexisting metabolic syndrome (MetSyn) often occurs. Receptor for advanced glycation end products (RAGE) is highly expressed in t

Externí odkaz: https://doaj.org/article/6965df6f7b0249098950ea45a7e3f322

Receptor for advanced glycation end-products and World Trade Center particulate induced lung function loss: A case-cohort study and murine model of acute particulate exposure.

Autor: Erin J Caraher, Sophia Kwon, Syed H Haider, George Crowley, Audrey Lee, Minah Ebrahim, Liqun Zhang, Lung-Chi Chen, Terry Gordon, Mengling Liu, David J Prezant, Ann Marie Schmidt, Anna Nolan

Publikováno v: PLoS ONE, Vol 12, Iss 9, p e0184331 (2017)

World Trade Center-particulate matter(WTC-PM) exposure and metabolic-risk are associated with WTC-Lung Injury(WTC-LI). The receptor for advanced glycation end-products (RAGE) is most highly expressed in the lung, mediates metabolic risk, and single-n

Externí odkaz: https://doaj.org/article/3798bf1395844da396d254d782928aa8

Synergistic Effect of WTC-Particulate Matter and Lysophosphatidic Acid Exposure and the Role of RAGE: In-Vitro and Translational Assessment

Autor: Angela Talusan, Sophia Kwon, Anna Nolan, Dean Ostrofsky, Yuyan Wang, Syed Hissam Haider, Erin J. Caraher, Rachel Lam, Mengling Liu, David J. Prezant, George Crowley

Publikováno v: International Journal of Environmental Research and Public Health
Volume 17
Issue 12
International Journal of Environmental Research and Public Health, Vol 17, Iss 4318, p 4318 (2020)

World Trade Center particulate matter (WTC-PM)-exposed firefighters with metabolic syndrome (MetSyn) have a higher risk of WTC lung injury (WTC-LI). Since macrophages are crucial innate pulmonary mediators, we investigated WTC-PM/lysophosphatidic aci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffa6500d88052cc639c220c8ca01cb83

Multiomics of World Trade Center Particulate Matter-induced Persistent Airway Hyperreactivity. Role of Receptor for Advanced Glycation End Products

Autor: Yuyan Wang, Rachel Lam, Sophia Kwon, Erin J. Caraher, Ann Marie Schmidt, Dean Ostrofsky, Syed Hissam Haider, Arul Veerappan, David J. Prezant, Anna Nolan, Mena Mikhail, Mengling Liu, George Crowley, Maria Sunseri

Publikováno v: Am J Respir Cell Mol Biol

Pulmonary disease after World Trade Center particulate matter (WTC-PM) exposure is associated with dyslipidemia and the receptor for advanced glycation end products (RAGE); however, the mechanisms are not well understood. We used a murine model and a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::035392a0d0337d561a1ca9971cd1aa0e
https://pubmed.ncbi.nlm.nih.gov/32315541