Increased late sodium current contributes to the electrophysiological effects of chronic, but not acute, dofetilide administration

Autor: Tobias Opthof, Xiaoliang Qiu, Tove S. Rosen, Steven J. Feinmark, Ira S. Cohen, Evgeny P. Anyukhovsky, Richard Z. Lin, Erin Harleton, Tania Rahim, Samuel Chauveau, Ruben Coronel, Michael R. Rosen, Michiel J. Janse, Ya Ping Jiang

Publikováno v: Circulation. Arrhythmia and Electrophysiology, 9(4). Lippincott Williams and Wilkins
Circulation. Arrhythmia and electrophysiology, 9(4). Lippincott Williams and Wilkins

Background— Drugs are screened for delayed rectifier potassium current ( I Kr ) blockade to predict long QT syndrome prolongation and arrhythmogenesis. However, single-cell studies have shown that chronic (hours) exposure to some I Kr blockers (eg,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47fa30e21f01bca54a955cf6e76544e5
https://dspace.library.uu.nl/handle/1874/345845

Regulatory Domain Determinants That Control PKD1 Activity*

Autor: Susan F. Steinberg, Jianfen Guo, Fan Zhang, Vitalyi O. Rybin, Erin Harleton

The canonical pathway for protein kinase D1 (PKD1) activation by growth factor receptors involves diacylglycerol binding to the C1 domain and protein kinase C-dependent phosphorylation at the activation loop. PKD1 then autophosphorylates at Ser916, a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42ff2e5a9786f8aec0ac4c2732c46377
https://europepmc.org/articles/PMC3391082/

Tyrosine Phosphorylation Modifies Protein Kinase C δ-dependent Phosphorylation of Cardiac Troponin I*

Autor: Aaron C. Hinken, R. John Solaro, Marius P. Sumandea, Susan F. Steinberg, Vitalyi O. Rybin, Chaojian Wang, Gail Sievert, C. William Balke, Tomoyoshi Kobayashi, Steven J. Feinmark, Erin Harleton

Our study identifies tyrosine phosphorylation as a novel protein kinase Cdelta (PKCdelta) activation mechanism that modifies PKCdelta-dependent phosphorylation of cardiac troponin I (cTnI), a myofilament regulatory protein. PKCdelta phosphorylates cT

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0cced2685743dbaf8f7035a0b5ad993
https://europepmc.org/articles/PMC2504892/

Roles of the threonine 407, aspartic acid 417, and threonine 419 residues in P450 2B1 in metabolism

Autor: Chitra Sridar, Erin Harleton, Paul F. Hollenberg

Publikováno v: Biochemical and biophysical research communications. 338(1)

We have previously observed that the quadruple (S407T-N417D-A419T-K473M) and triple (S407T-N17D-A419T) mutants of the chimeric construct of P450 2B1/2B2 do not undergo mechanism-based inactivation by 17α-ethynylestradiol (17EE) and tert-butyl 1-meth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f83da8fc91d4e3766f574c2ea49f07b
https://pubmed.ncbi.nlm.nih.gov/16157292

Metabolism of N,N',N"-triethylenethiophosphoramide by CYP2B1 and CYP2B6 results in the inactivation of both isoforms by two distinct mechanisms.

Autor: Erin, Harleton, Marie, Webster, N, Bumpus Namandj, M, Kent Ute, M, Rae James, F, Hollenberg Paul

Publikováno v: The Journal of Pharmacology and Experimental Therapeutics; September 2004, Vol. 310 Issue: 3 p1011-9, 9p