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Autor:
Kayla Dempster, Michael W. Staude, Elizaveta Kovrigina, Sara Braynard, Erin Graney, Jamie VanPelt, Jeffrey W. Peng, Heath A. Rose, Sarah Graney, Shannon Stoffel, David A. Leonard
Publikováno v:
J Mol Biol
The resistance of Gram-negative bacteria to β-lactam antibiotics stems mainly from β-lactamase proteins that hydrolytically deactivate the β-lactams. Of particular concern are the β-lactamases that can deactivate a class of β-lactams known as ca