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pro vyhledávání: '"Erin Gauntner"'
Autor:
Erin Gauntner, Alan L. Maycock, Virendra Kumar, Patrick J. Little, Michael Koblish, Erik Mansson, Diane L. DeHaven-Hudkins, Susan L. Gottshall, Robert N. DeHaven, Joel A. Cassel, Susan L. Greiner, Jeffrey D. Daubert, Deqi Guo
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:1091-1095
A series of 3-substituted analogs (3) of the parent kappa agonist, 1, were prepared to limit access to the central nervous system. With the exception of compound 3j, all other compounds bound to the human kappa opioid receptor with high affinity (K(i