Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Erin G. Conlon"'
Autor:
Erin G Conlon, Delphine Fagegaltier, Phaedra Agius, Julia Davis-Porada, James Gregory, Isabel Hubbard, Kristy Kang, Duyang Kim, The New York Genome Center ALS Consortium, Hemali Phatnani, Neil A Shneider, James L Manley
Publikováno v:
eLife, Vol 7 (2018)
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) represent two ends of a disease spectrum with shared clinical, genetic and pathological features. These include near ubiquitous pathological inclusions of the RNA-binding protein (
Externí odkaz:
https://doaj.org/article/6a553bbbe58441b295a55118484442ea
Autor:
Michel C. Nussenzweig, Caryn R Hale, Christian Gaebler, Paul D. Bieniasz, Dennis Schaefer-Babajew, Richard P. Lifton, Robert B. Darnell, Frauke Muecksch, Justin DaSilva, Erin G. Conlon, Ezgi Hacisuleyman, Theodora Hatziioannou, Yuhki Saito, Nathalie E. Blachère, Marissa Bergh
Publikováno v:
New England Journal of Medicine. 384:2212-2218
Emerging variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are of clinical concern. In a cohort of 417 persons who had received the second dose of BNT162b2 (Pfizer-BioNTech) or mRNA-1273 (Moderna) vaccine at least 2 weeks previ
Autor:
Erin G Conlon, Lei Lu, Aarti Sharma, Takashi Yamazaki, Timothy Tang, Neil A Shneider, James L Manley
Publikováno v:
eLife, Vol 5 (2016)
An expanded GGGGCC hexanucleotide in C9ORF72 (C9) is the most frequent known cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). It has been proposed that expanded transcripts adopt G-quadruplex (G-Q) structures and associ
Externí odkaz:
https://doaj.org/article/d8128c60d131440f9b78ad600e2de93a
Publikováno v:
Genome Res
Genome research, vol 30, iss 12
Genome research, vol 30, iss 12
The GGGGCC hexanucleotide expansion in C9orf72 (C9) is the most frequent known cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), yet a clear understanding of how C9 fits into the broader context of ALS/FTD pathology has
Publikováno v:
RNA Biol
Burkitt lymphoma (BL) is an aggressive B-cell lymphoma characterized by translocation and deregulation of the proto-oncogene c-MYC. Transcription factor 3 (TCF3) has also been shown to be involved in BL pathogenesis. In BL, TCF3 is constitutively act
Autor:
Erin G Conlon, James L. Manley
Publikováno v:
Genes & Development. 31:1509-1528
Neurodegeneration is a leading cause of death in the developed world and a natural, albeit unfortunate, consequence of longer-lived populations. Despite great demand for therapeutic intervention, it is often the case that these diseases are insuffici
Autor:
Andrea Malaspina, Timothy M. Miller, Joshua Dubnau, Eran Hornstein, Julia Davis-Porada, Frank Baas, Dhruv Sareen, Zachary Simmons, Kristy Kang, Avindra Nath, Daniel J. L. MacGowan, Leslie M. Thompson, James D. Berry, James Gardner Gregory, Pietro Fratta, Hemali Phatnani, Nikolaos A. Patsopoulos, Justin Y. Kwan, Neil A. Shneider, Steve Finkbeiner, Ernest Fraenkel, Edward B. Lee, Lyle Ostrow, Noah Zaitlen, James R. Broach, Isabel Hubbard, Phaedra Agius, Delphine Fagegaltier, Ximena Arcila-Londono, Duyang Kim, Vivianna M. Van Deerlin, Terry Heiman-Patterson, Erin G Conlon, James L. Manley, Molly G Hammell, Siddharthan Chandran, Efthimios Dardiotis, Gregory A. Cox, Suvankar Pal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca7819aeaaf64072f8f03328a10d8e17
https://doi.org/10.7554/elife.37754.025
https://doi.org/10.7554/elife.37754.025
Autor:
Erin G Conlon, James L. Manley
Publikováno v:
Genesdevelopment. 31(19)
This review by Conlon and Manley focuses on RNA processing in neurodegeneration. It describes how neurons are particularly vulnerable to disruption of RNA-binding proteins (RBPs), leading to a wide range of neurological and neurodegenerative diseases