Characterization of Distinct Biofilm Cell Subpopulations and Implications in Quorum Sensing and Antibiotic Resistance

Autor: Taylor A. Dodson, Eric A. Carlson, Nathan C. Wamer, Chase N. Morse, Jennifer N. Gadient, Erin G. Prestwich

Publikováno v: mBio, Vol 13, Iss 3 (2022)

ABSTRACT Bacteria change phenotypically in response to their environment. Free swimming cells transition to biofilm communities that promote cellular cooperativity and resistance to stressors and antibiotics. We uncovered three subpopulations of cell

Externí odkaz: https://doaj.org/article/3fccb83754504d0db15f07bfb8277a34

Comparison of Small Biomolecule Ionization and Fragmentation in Pseudomonas aeruginosa Using Common MALDI Matrices

Autor: Nathan C. Wamer, Chase N. Morse, Jennifer N. Gadient, Taylor A. Dodson, Eric A. Carlson, Erin G. Prestwich

Publikováno v: Journal of the American Society for Mass Spectrometry. 34:355-365

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d5750865271ef2e0b3248e66caf22289
https://doi.org/10.1021/jasms.2c00157

Crystal structure and catalytic mechanism of the essential m1G37 tRNA methyltransferase TrmD from Pseudomonas aeruginosa

Autor: Somchart Maenpuen, Narumon Thongdee, Erin G. Prestwich, Skorn Mongkolsuk, Wenhe Zhong, Abbas El Sahili, Sopapan Atichartpongkul, Yok Hian Chionh, Megan E. McBee, Julien Lescar, Chong Wai Liew, Juthamas Jaroensuk, Pimchai Chaiyen, Yee Hwa Wong, Peter C. Dedon, Michael S. DeMott, Mayuree Fuangthong, Qianhui Nah

Publikováno v: RNA. 25:1481-1496

The tRNA (m1G37) methyltransferase TrmD catalyzes m1G formation at position 37 in many tRNA isoacceptors and is essential in most bacteria, which positions it as a target for antibiotic development. In spite of its crucial role, little is known about

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::10d0f9510160f0ccf682b4a455242e3b
https://doi.org/10.1261/rna.066746.118

Methylation at position 32 of tRNA catalyzed by TrmJ alters oxidative stress response inPseudomonas aeruginosa

Autor: Narumon Thongdee, Julien Lescar, Juthamas Jaroensuk, Michael S. DeMott, Chong Wai Liew, Mayuree Fuangthong, Yee Hwa Wong, Yok Hian Chionh, Sopapan Atichartpongkul, Skorn Mongkolsuk, Peter C. Dedon, Megan E. McBee, Erin G. Prestwich

Publikováno v: Nucleic Acids Research
Nucleic Acids Research, 2016, 44 (22), pp.10834-10848. ⟨10.1093/nar/gkw870⟩
Oxford University Press
Nucleic Acids Research, Oxford University Press, 2016, 44 (22), pp.10834-10848. ⟨10.1093/nar/gkw870⟩

Bacteria respond to environmental stresses using a variety of signaling and gene expression pathways, with translational mechanisms being the least well understood. Here, we identified a tRNA methyltransferase in Pseudomonas aeruginosa PA14, trmJ, wh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3ca8694e4caaaaf4dfd2356adbe83a5
https://doi.org/10.1093/nar/gkw870

Mycobacterium tuberculosis Transfer RNA Induces IL-12p70 via Synergistic Activation of Pattern Recognition Receptors within a Cell Network

Autor: Robert L. Modlin, Dan Su, Caroline Keegan, Philip O. Scumpia, David Elashoff, Jing Lu, Erin G. Prestwich, Robert M. Hershberg, Sarah M. Fortune, Mirjam Schenk, Yan Ling Joy Pang, Brandon S Russell, Peter C. Dedon, Scarlet S. Shell, John T. Belisle, Stephan R. Krutzik, Kok Seong Lim, Matteo Pellegrini, Barry R. Bloom

Publikováno v: Journal of immunology (Baltimore, Md. : 1950), vol 200, iss 9
PMC

Available in PMC 2019 May.
Upon recognition of a microbial pathogen, the innate and adaptive immune systems are linked to generate a cell-mediated immune response against the foreign invader. The culture filtrate of Mycobacterium tuberculosis co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46f6638226578d8b618880269e8448d4
https://escholarship.org/uc/item/0zm230rw